Influence of NaCl on Granulometric Characteristics and Polymorphism in Batch‐Cooling Crystallization of Glycine

Hrkovac, Martina; Kardum, Jasna Prlić; Ukrainczyk, Neven

doi:10.1002/ceat.201400462

Cited by 7 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PXRD patterns for α-form and γ-form crystals differed due to the different molecular arrangements in their crystalline structures. The α-form structure was identified by characteristic peaks at 2θ of ~19.05 • , ~29.9 • , and ~35.4 • , and the γ-form structure was identified by characteristic peaks at 2θ of ~21.8 • , ~25.3 • , and ~39.1 • [30,32]. Here, all the PXRD patterns were obtained with a slow scan rate of 0.02 • /s, and no characteristic peaks of β-form were observed at ~18.0 • or ~24.8 • , which also confirmed that there was no β-form in the samples [30,32,33].…”

Section: Resultsmentioning

confidence: 99%

Investigation of Glycine Polymorphic Transformation by In Situ ATR-FTIR and FT-Raman Spectroscopy

Zhang

2022

Crystals

View full text Add to dashboard Cite

The solution-mediated phase transformation of α-form to γ-form glycine, including dissolution of metastable α-form, nucleation, and growth of stable γ-form during polymorphic transformation, was investigated using in situ attenuated total-reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and Fourier transform Raman spectroscopy (FT-Raman). The mechanistic influence of operating parameters such as agitation speed, crystallization temperature, α-form seed concentration, and NaCl concentration on polymorphic phase transformation was examined. When the agitation speed, crystallization temperature, and NaCl concentration were increased, the polymorphic transformation process was improved due to the promotion of nucleation and growth of stable γ-form, in addition to the promotion of dissolution of metastable α-form. Moreover, the time to induce γ-form nucleation and complete conversion of α-form to γ-form was also reduced with increasing α-form seed concentration.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of Glycine Polymorphic Transformation by In Situ ATR-FTIR and FT-Raman Spectroscopy

Zhang

2022

Crystals

View full text Add to dashboard Cite

show abstract

“…Crystallization is a separation process utilized in the chemical, food, and pharmaceutical industries to purify or produce a new solid phase from a solution, suspension, or melt [1]. Various factors, such as temperature, agitation, saturation, supersaturation, or the presence of additives, can influence the implementation and outcome of the crystallization process by impacting the crystal growth, morphology, and internal structure of obtained crystals [2]. Crystalline form, size, and shape directly affect the physical and chemical properties of solids such as solubility and dissolution rate, as well as downstream processes such as filtration, milling, drying, or tableting; therefore, it is important to have control over the crystallization process.…”

Section: Introductionmentioning

confidence: 99%

Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies

Zokić,

Prlić Kardum

2023

ChemEngineering

View full text Add to dashboard Cite

Because of the specific thermodynamic properties of active pharmaceutical ingredients, the process of crystallization often meets implementation challenges in the pharmaceutical industry. Therefore, it is essential to select the appropriate method and system for the crystallization of a drug. Ceritinib, an active ingredient in the treatment of lung cancer, was formed as a result of pH modification during the cooling crystallization of ceritinib dihydrochloride solution. By carrying out processes in various solvent systems, several polymorphs were produced. A combination of forms B and C was generated in the ethanol–water system, resulting in smaller crystals. The acetone–water system produced pure form A, which has larger crystals and is more applicable for forthcoming studies. To additionally enhance granulometric properties, ceritinib form A was recrystallized in tetrahydrofuran at different temperatures using antisolvent crystallization. Crystallization at a higher saturation temperature results in larger and more compact crystals, which enhances filtration and drying.

show abstract

“…The effect of acidity on solubility is also very obvious, for example, S. Mishra et al found that the solubility of triisoamyl phosphate first decreased and then increased with the increase of acidity [8]. Crystallization is a key step in the separation and purification, and the factors that affect crystallization are often the influence of temperature, supersaturation, stirring rate, and additives, adding additives to the solution will cause a change in the solubility of the crystalline components, which mainly depends on the role of foreign ions and pH value [9]. GAH plays an important role in the human body [10].…”

Section: Introductionmentioning

confidence: 99%

Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives

Pan,

Wang,

Xie

et al. 2023

Crystals

View full text Add to dashboard Cite

Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous system with the presence of three kinds of additives (HCl, NaCl, KCl) at temperatures ranging from 278.15 K to 323.15 K was determined by gravimetric method. When there are additives in water, the solubility of GAH increases with the increase of temperature and decreases with the increase of concentration of the three kinds of additives. When the additives were at similar mole fractions, HCl led to the lowest solubility of GAH. The modified Apelblat model and van’t Hoff model were used to correlate the solubility data. The average relative deviation (ARD) data of Apelblat and van’t Hoff models were less than 5%, indicating good fitting results. Based on the thermodynamic data, the cooling crystallization process of GAH was performed. It was found that the additives could affect the crystal morphology, particle size, and yield of GAH products. This study supplemented the thermodynamic data of GAH and studied the cooling crystallization process in the presence of GAH additives, which provided important guidance for the optimization of the crystallization process.

show abstract

Influence of NaCl on Granulometric Characteristics and Polymorphism in Batch‐Cooling Crystallization of Glycine

Cited by 7 publications

References 21 publications

Investigation of Glycine Polymorphic Transformation by In Situ ATR-FTIR and FT-Raman Spectroscopy

Investigation of Glycine Polymorphic Transformation by In Situ ATR-FTIR and FT-Raman Spectroscopy

Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies

Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives

Contact Info

Product

Resources

About