Influence of nucleotide excision repair of Escherichia coli on radiation-induced mutagenesis of double-stranded M13 DNA

The C-terminal Domain of MutY Glycosylase Determines the 7,8-Dihydro-8-oxo-guanine Specificity and Is Crucial for Mutation Avoidance

“…The inhibition of MutM activity is especially important if T/GO and G/GO mismatches arise from misincorporation of T and G opposite oxidized template guanines as well as if T/GO mismatches are derived from deamination of 5-methylcytosine opposite GO. DNA polymerases may incorporate G or T opposite the GO lesions as suggested by Braun et al (59). An oxidized form of GO, possibly guanidinohydantoin, may direct misincorporation of dNTPs during DNA synthesis (58).…”