Influence of nutrition on liver oxidative metabolism

Jorquera, Francisco; Culebras, Jesús M.; González‐Gallego, Javier

doi:10.1016/s0899-9007(96)00101-3

Cited by 22 publications

(10 citation statements)

References 52 publications

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“…The expression of these enzymes varies between individuals and is affected by genetic and environmental factors, including nutritional status (Jorquera et al, 1996). The CYP450 enzymes are responsible for the metabolism of many anti-neoplastic agents, including etoposide and teniposide .…”

Section: Hepatic Metabolismmentioning

confidence: 99%

Impact of nutrition on pharmacokinetics of anti-neoplastic agents

Murry¹,

Riva²,

Poplack³

1998

Int. J. Cancer

106

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Section: Hepatic Metabolismmentioning

confidence: 99%

Impact of nutrition on pharmacokinetics of anti-neoplastic agents

Murry¹,

Riva²,

Poplack³

1998

Int. J. Cancer

106

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“…CCl 4 induces liver necrosis and Kupffer cells may possibly phagocytose the necrotic cell remnants. CCl 4 metabolites react with polyunsaturated fatty acids to propagate a chain reaction leading either to lipid peroxidation or binding covalently to lipids and proteins, resulting in destruction of cell membranes and liver damage [14,15]. It is well documented that antioxidants play a significant role in protecting living organisms from the toxic effects of chemical substances such as carbon tetrachloride and carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective potential ofAegle marmelos Correa.against CCl₄-induced oxidative stress and early tumor events

Khan

Sultana

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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The antioxidant properties and inhibitory effect on early tumor promoter markers of A. marmelos (25 and 50 mg/Kg b. wt. orally) have been evaluated. Male Wistar rats were pre-treated for seven consecutive days with A. marmelos prior to CCl 4 (1 mL Kg 21 body weight p. o., in corn oil [1:1 v/v]) treatment. Pre-treatment with A. marmelos suppressed lipid peroxidation (LPO), xanthine oxidase (XO) and release of serum toxicity marker enzymes viz, SGOT, LDH, SGPT dose-dependently and significantly (p , 0.001). Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT) were concomitantly restored in A. marmelos-treated groups (p , 0.001). In addition, A. marmelos pretreatment also prevented the CCl 4 -enhanced ornithine decarboxylase (ODC) and hepatic DNA synthesis significantly (p , 0.001). In conclusion, carbon tetrachloride-induced liver toxicity was strikingly attenuated by A. marmelos treatment and the study gives some insight into the mechanisms involved in diminution of free radical generating toxicants and enhancement of the antioxidant armory, hence preventing further tissue damage, injury and hyperproliferation.Thus, these findings indicate that A. marmelos attenuates CCl 4 -mediated hepatic oxidative stress, toxicity, tumor promotion and subsequent cell proliferation response in Wistar rats.

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“…Our observations concerning the decrease of cytochrome P-450 during TPN agree with other reports. 6,13,14 Our results highlight the putative relation between the decrease of liver membrane unsaturation occurring during TPN and the decrease of the oxidative metabolism capacity. The effect of the route of administration (Oral us TPN) and of oil composition (S vs 0) were tested by two-way analysis of variance.…”

Section: Discussionmentioning

confidence: 58%