Influence of obesity in central blood pressure

Abstract

Overweight and obesity tend to have lower central SBP as compared to lean patients, mainly in women. Further research is required to assess the interaction between body weight and vascular dynamics and their clinical implications.

Central Blood Pressure Parameters Correlate with Cardiac Structure and Function in Healthy Chinese Individuals without Cardiovascular Disease

“…We used the E/A ratio. However, sinus tachycardia and first-degree AV block can result in partial or complete fusion of the mitral E and A waves [33]. Subherwal et al [31] used the E/Em ratio, which is an important ratio for the estimation of LV filling pressures.…”

“…Subherwal et al [31] used the E/Em ratio, which is an important ratio for the estimation of LV filling pressures. In healthy subjects, Em velocity is positively related to preload, and so the E/Em ratio may not provide a reliable estimate of filling pressures in these patients [33]. Additionally, Em velocity is usually reduced in patients with significant annular calcification, surgical rings, mitral stenosis, or prosthetic mitral valves [33].…”

“…In healthy subjects, Em velocity is positively related to preload, and so the E/Em ratio may not provide a reliable estimate of filling pressures in these patients [33]. Additionally, Em velocity is usually reduced in patients with significant annular calcification, surgical rings, mitral stenosis, or prosthetic mitral valves [33]. (2) The study by Subherwal et al [31] included a population consisting of 47% hypertensive and 22% diabetic patients.…”

“…(3) The participants in the Subherwal et al [31] study had a much higher average BMI than our study participants (29.5 ± 6.3 vs. 23.86 ± 3.25). Pichler et al [33] reported that overweight and obese people tend to have a lower central SBP when compared with lean patients. (4) The different ethnic backgrounds of the participants in each study could also account for the observed differences between studies.…”

Association of Haemodynamic Indices of Central and Peripheral Pressure with Subclinical Target Organ Damage

“…The reason for these different results is mainly in the difference in adjusting for confounding factors. The fact that age [17,18], antihypertensive drugs [19], body mass index or height [20] can influence the amplification of systolic pressure between central and upper limb arteries can play an important role in the adjusted factors. For example, antihypertensive therapy can have different effects on central and peripheral systolic pressure, influencing TOD, reducing left ventricular hypertrophy (LVH), cfPWV, carotid IMT and ACR [19,21].…”