Influence of operating parameters on supercritical fluid extraction of essential oil from turmeric root

Choudhary, Priyanka; Khanam, Shabina

doi:10.1016/j.jclepro.2018.04.052

Cited by 66 publications

(19 citation statements)

References 30 publications

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“…Especially, due to the lipophilic nature of CO 2 , SFE is very suitable for the extraction of non-polar or moderately polar ingredients. Therefore, the use of SFE to extract plants is rapidly increasing [32,33,34].…”

Section: Introductionmentioning

confidence: 99%

Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells

et al. 2018

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Bulnesia sarmientoi (BS) has long been used as an analgesic, wound-healing and anti-inflammatory medicinal plant. The aqueous extract of its bark has been demonstrated to have anti-cancer activity. This study investigated the anti-proliferative and anti-metastatic effects of BS supercritical fluid extract (BSE) on the A549 and H661 lung cancer cell lines. The cytotoxicity on cancer cells was assessed by an MTT assay. After 72 h treatment of A549 and H661 cells, the IC50 values were 18.1 and 24.7 μg/mL, respectively. The cytotoxicity on MRC-5 normal cells was relatively lower (IC50 = 61.1 μg/mL). BSE arrested lung cancer cells at the S and G2/M growth phase. Necrosis of A549 and H661 cells was detected by flow cytometry with Annexin V-FITC/PI double staining. Moreover, the cytotoxic effect of BSE on cancer cells was significantly reverted by Nec-1 pretreatment, and BSE induced TNF-α and RIP-1 expression in the absence of caspase-8 activity. These evidences further support that BSE exhibited necroptotic effects on lung cancer cells. By wound healing and Boyden chamber assays, the inhibitory effects of BSE on the migration and invasion of lung cancer cells were elucidated. Furthermore, the chemical composition of BSE was examined by gas chromatography-mass analysis where ten constituents of BSE were identified. α-Guaiene, (−)-guaiol and β-caryophyllene are responsible for most of the cytotoxic activity of BSE against these two cancer cell lines. Since BSE possesses significant cytotoxicity and anti-metastatic activity on A549 and H661 cells, it may serve as a potential target for the treatment of lung cancer.

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Section: Introductionmentioning

confidence: 99%

Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells

et al. 2018

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“…The -CH 3 and -CH 2 stretching vibrations were observed around 2967 and 2925 cm −1 , respectively [ 26 , 27 ]. The peak around 1680 cm −1 was attributed to C=O vibrations [ 27 ] and the peaks at 1624 cm −1 and 1600 cm −1 were assigned to the aromatic ring stretching (C=C) and to a mixture of C=C and C=O stretching, respectively [ 20 , 26 , 27 ]. The band at around 1430 cm −1 was ascribed to CH 2 bending, while the peak around 1377 cm −1 was assigned to CH 3 bending indicating the presence of curcuminoids [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, these methods require high energy, temperatures and solvent consumption, in addition to long reaction times leading consequently to the degradation of many compounds and low yields [ 2 , 18 ]. Therefore, eco-friendly alternatives including ultrasound assisted extraction, supercritical fluids (mainly supercritical carbon dioxide) and microwave assisted extraction (MAE) have been studied [ 17 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Extraction of Curcuma longa L. Oil: Optimization, Chemical Structure and Composition, Antioxidant Activity and Comparison with Conventional Soxhlet Extraction

et al. 2021

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Curcuma root (Curcuma longa L.) is a very important plant in gastronomy and medicine for its unique antiseptic, anti-inflammatory, antimicrobial and antioxidant properties. Conventional methods for the extraction of curcuma oil require long extraction times and high temperatures that can degrade the active substances. Therefore, the objectives of the present study were: (i) first, to optimize the extraction yield of curcuma oil by applying a Box-Behnken experimental design using surface response methodology to the microwave-assisted extraction (MAE) technique (the independent variables studied were reaction time (10–30 min), microwave power (150–200 W) and curcuma powder/ethanol ratio (1:5–1:20; w/v); and, (ii) second, to assess the total phenolic content (TPC) and their antioxidant activity of the oil (at the optimum conditions point) and compare with the conventional Soxhlet technique. The optimum conditions for the MAE were found to be 29.99 min, 160 W and 1:20 w/v to obtain an optimum yield of 10.32%. Interestingly, the oil extracted by microwave-assisted extraction showed higher TPC and better antioxidant properties than the oil extracted with conventional Soxhlet technique. Thus, it was demonstrated that the method applied for extraction influences the final properties of the extracted Curcuma longa L. oil.

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“…In the present study the mean particle size of the H. pluvialis powder was Dp = 0.32 ± 0.01 mm. Priyanka [ 40 ] reports that if the particle size is too small, channeling of fluids can occur within the fixed bed resulting in inhomogeneous extraction. On the other hand, for larger particles, the cell walls do not break where the oil is trapped.…”

Section: Resultsmentioning

confidence: 99%

Effect of CO2 Flow Rate on the Extraction of Astaxanthin and Fatty Acids from Haematococcus pluvialis Using Supercritical Fluid Technology

et al. 2020

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Haematococcus pluvialis is the largest producer of natural astaxanthin in the world. Astaxanthin is a bioactive compound used in food, feed, nutraceutics, and cosmetics. In this study, astaxanthin extraction from H. pluvialis by supercritical fluid extraction was evaluated. The effects of temperature (40 and 50 °C), pressure (40 and 50 MPa), and CO2 flow rate (2 and 4 L/min) were investigated. The results showed that the highest astaxanthin recovery was obtained at 50 °C/50 MPa and the CO2 flow rates evaluated had no significant effect. It was possible to achieve astaxanthin recoveries of 95% after 175 min for a CO2 flow rate of 2 L/min, and 95 min for CO2 flow rate of 4 L/min. The ω-6/ω-3 ratios obtained were similar in all conditions, reaching 0.87, demonstrating that the extracts from H. pluvialis by SFE are rich in unsaturated fatty acids (UFA) which increases their positive effects when used as a functional ingredient in food.

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Influence of operating parameters on supercritical fluid extraction of essential oil from turmeric root

Cited by 66 publications

References 30 publications

Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells

Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells

Microwave-Assisted Extraction of Curcuma longa L. Oil: Optimization, Chemical Structure and Composition, Antioxidant Activity and Comparison with Conventional Soxhlet Extraction

Effect of CO2 Flow Rate on the Extraction of Astaxanthin and Fatty Acids from Haematococcus pluvialis Using Supercritical Fluid Technology

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