Influence of osteoclasts and osteoprotegerin on the mode of calcific degeneration of aortic valves

Lis, Grzegorz; Czubek, Urszula; Jasek-Gajda, Ewa; Łoboda, Agnieszka; Dulak, Józef; Nessler, Jadwiga; Kapelak, Bogusław; Sadowski, Jerzy; Litwin, Jan A.

doi:10.20452/pamw.3326

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…OPG may also participate in the calcific degeneration of the heart valves. 33 This study has demonstrated that increased PTX3 concentrations significantly predict CV mortality in patients with advanced CKD regardless of serum OPG and hs -CRP levels, the presence of In the Multi -Ethnic Study of Atherosclerosis (MESA), 21 PTX3 was not associated with the risk of stroke, CV death, or non -CV death but it was related to increased risk of MI, CVD, and CHF events. The authors showed that in a population--based study of men and women from 4 ethnic groups (2880 participants with a follow -up of 8.5 years) who were free of clinical CVD these associations were independent of hs -CRP levels.…”

Section: Discussionmentioning

confidence: 81%

Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

Krzanowski¹,

Krzanowska²,

Gajda³

et al. 2017

Polish Archives of Internal Medicine

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Section: Discussionmentioning

confidence: 81%

Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

Krzanowski¹,

Krzanowska²,

Gajda³

et al. 2017

Polish Archives of Internal Medicine

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“…В настоящей работе, так же как и в работах Akat К и Lis G, et al, получены более высокие значения концентрации OPG у пациентов с ТАК и АС по сравнению с группой контроля [3,11]. У пациентов с БАК повышение OPG было не настолько значимо.…”

Section: Discussionunclassified

“…Ранее опубликованные исследования показывают, что взаимодействие RANKL/RANK может стимулировать кальцификацию как сосудистой стенки, так и клапанов сердца. OPG действует как рецепторприманка для проостеокластического RANKL и поэтому может ингибировать процесс кальцификации [3,4]. Коэффициент соотношения OPG/RANKL определяет направленность воздействия системы сигналинга на остеокласты.…”

Section: Aimunclassified

The Role of Osteoprotegerin System /Rankl/Rank in Pathogenesis of Aortic Stenosis

Иртюга¹,

Жидулева²,

Murtazalieva³

et al. 2018

Russ J Cardiol

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Цель. Оценить концентрацию остеопротегерина (OPG) и растворимого лиганда рецептора активатора фактора транскрипции каппа-В (sRANKL) в сыворотке крови у больных с различной степенью тяжести аортального стеноза (АС). Материал и методы. Обследовано 247 больных с АС различной степени тяжести: 46 пациентов с легкой степенью тяжести, 53 пациента с умеренным АС и 149 с тяжелым АС. Из них 132 (53%) пациента с бикуспидальным аортальным клапаном (БАК) и 115 (47%) с трикуспидальным аортальным клапаном (ТАК). Контрольную группу составили 58 пациентов без клапанной патологии сердца и ишемической болезни сердца. У всех пациентов определяли липидный профиль, сывороточный уровень С-реактивного белка (СРБ), OPG и sRANKL. Результаты. Во всех исследуемых группах больных с АС выявлено повышение содержания sRANKL в сыворотке крови в сравнении с контрольной группой (БАК =0,37 [0,32;0,53] пмоль/л, ТАК =0,38 [0,33;0,50] пмоль/л, контрольная группа 0,30 [0,21;0,39] пмоль/л; р<0,0001. Концентрация OPG была повышена только у больных с ТАК: 6,99 [5,19;9,90] пмоль/л; по сравнению с 5,23 [4,30;7,09] пмоль/л у пациентов с БАК (р=0,0008). Высказана гипотеза, что рост концентрации OPG является компенсаторным и возникает в ответ на повышение уровня или нарушение чувствительности к sRANKL. Заключение. Развитие АС сопряжено с нарушениями в системе OPG/RANKL, а выявление этих изменений может иметь важное диагностическое и прогностическое значение, особенно у пациентов с ТАК. Российский кардиологический журнал 2018, 2 (154): 39-43 http://dx.Ключевые слова: аортальный стеноз, кальциноз, биомаркеры, остеопротегерин, sRANKL. Russ J Cardiol 2018, 2 (154): 39-43 http://dx.

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“…It is associated with intravalvular inflammation, calcium and lipid deposition, and overproduction of the aberrant extracellular matrix, resulting in valve sclerosis and consequently, stenosis [ 1 , 2 ]. Discrete calcification occurs very early in this pathology, leading with time to irreversible, substantial calcific degeneration, and sometimes ossification [ 1 , 3 , 4 , 5 ]. Theories on mechanisms involved in CAVD development have been evolving through the years, leading to the currently accepted view, that at the tissue level, this pathology is a process actively regulated by various resident and migratory cells (e.g., interstitial or endothelial cells versus inflammatory cells) [ 1 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Discrete calcification occurs very early in this pathology, leading with time to irreversible, substantial calcific degeneration, and sometimes ossification [ 1 , 3 , 4 , 5 ]. Theories on mechanisms involved in CAVD development have been evolving through the years, leading to the currently accepted view, that at the tissue level, this pathology is a process actively regulated by various resident and migratory cells (e.g., interstitial or endothelial cells versus inflammatory cells) [ 1 , 5 , 6 ]. Since the mechanism of this process remains unclear, there is still no effective treatment other than surgical replacement of the defective valve.…”

Section: Introductionmentioning

confidence: 99%

Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling

Lis

Dubrowski

Lis

et al. 2020

IJMS

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Aortic valve interstitial cells (VICs) constitute a heterogeneous population involved in the maintenance of unique valvular architecture, ensuring proper hemodynamic function but also engaged in valve degeneration. Recently, cells similar to telocytes/interstitial Cajal-like cells described in various organs were found in heart valves. The aim of this study was to examine the density, distribution, and spatial organization of a VIC subset co-expressing CD34 and PDGFRα in normal aortic valves and to investigate if these cells are associated with the occurrence of early signs of valve calcific remodeling. We examined 28 human aortic valves obtained upon autopsy. General valve morphology and the early signs of degeneration were assessed histochemically. The studied VICs were identified by immunofluorescence (CD34, PDGFRα, vimentin), and their number in standardized parts and layers of the valves was evaluated. In order to show the complex three-dimensional structure of CD34+/PDGFRα+ VICs, whole-mount specimens were imaged by confocal microscopy, and subsequently rendered using the Imaris (Bitplane AG, Zürich, Switzerland) software. CD34+/PDGFRα+ VICs were found in all examined valves, showing significant differences in the number, distribution within valve tissue, spatial organization, and morphology (spherical/oval without projections; numerous short projections; long, branching, occasionally moniliform projections). Such a complex morphology was associated with the younger age of the subjects, and these VICs were more frequent in the spongiosa layer of the valve. Both the number and percentage of CD34+/PDGFRα+ VICs were inversely correlated with the age of the subjects. Valves with histochemical signs of early calcification contained a lower number of CD34+/PDGFRα+ cells. They were less numerous in proximal parts of the cusps, i.e., areas prone to calcification. The results suggest that normal aortic valves contain a subpopulation of CD34+/PDGFRα+ VICs, which might be involved in the maintenance of local microenvironment resisting to pathologic remodeling. Their reduced number in older age could limit the self-regenerative properties of the valve stroma.

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Influence of osteoclasts and osteoprotegerin on the mode of calcific degeneration of aortic valves

Cited by 6 publications

References 14 publications

Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

The Role of Osteoprotegerin System /Rankl/Rank in Pathogenesis of Aortic Stenosis

Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling

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