Influence of osteophytic size on bone mineral density measured by dual x-ray absorptiometry

Rand, Th.; Schneider, Barbara; Grampp, S.; Wunderbaldinger, Patrick; Migsits, H.; Imhof, Herwig

doi:10.1080/02841859709172051

Cited by 33 publications

(6 citation statements)

References 19 publications

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“…Femoral neck and not lumbar spine BMD was used for adjustment because we had no data on possible osteophytes of the lumbar spine. Such osteophytes may lead to an overestimation of the lumbar spine BMD and is, therefore, less suitable for adjustment (28, 29). Additionally, analyses stratified by sex were performed on both the vertebral and nonvertebral fracture groups.…”

Section: Methodsmentioning

confidence: 99%

Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: The Rotterdam Study

Bergink¹,

Klift²,

Hofman³

et al. 2003

Arthritis & Rheumatism

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Objective. To study the association between prevalent radiographic osteoarthritis (ROA) of the knee and incident vertebral and nonvertebral fractures. Methods. A sample of 2,773 subjects was drawn from the Rotterdam Study, a prospective population-based cohort study of the elderly. Status on knee ROA was assessed at baseline using the Kellgren score. Incident nonvertebral fractures were scored for all subjects, and for 1,466 subjects additional data on incident vertebral fractures were available. Results. Although people with ROA had a higher bone mineral density (BMD), their incident fracture risk was increased as compared with those without ROA. After adjustment for potential confounding factors, including parameters of postural stability, the relative risks for incident vertebral and nonvertebral fractures in the presence of knee ROA were 2.0 (95% confidence interval [95% CI] 1.1-3.4) and 1.5 (95% CI 1.1-2.0), respectively. Conclusions: Knee ROA is associated with an increased risk of incident vertebral and nonvertebral fractures, independent of BMD and parameters of postural stability.

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Section: Methodsmentioning

confidence: 99%

Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: The Rotterdam Study

Bergink¹,

Klift²,

Hofman³

et al. 2003

Arthritis & Rheumatism

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“…Women with a recent hip fracture also had sustained a greater number of previous fractures than women with a recent forearm fracture. On the other hand, there was a less clear correlation between vertebral BMD and the number of previous fractures, which may be ascribed to vertebral compressions and degenerative diseases of the spine (Rand et al 1997, Kanis and Gluer 2000, Muraki et al 2004). Although Torgerson et al (1996) reported a 6-times increased risk of fracture in perimenopausal women with two or more previous fractures, and Ross et al (1993) reported that the presence of one or two fractures increased the risk of new vertebral fractures by a factor of 7, the predictive value of multiple fractures has seldom been studied or considered in other reports.…”

Section: Is the Number Of Previous Fractures A Good Marker For Risk Omentioning

confidence: 99%

Women with low-energy fracture should be investigated for osteoporosis

et al. 2007

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Introduction Treatment of osteoporosis is becoming more effective, but methods to identify patients who are most suitable for investigation and treatment are still being debated. Should any type of fracture have higher priority for investigation of osteoporosis than any other? Is the number of previous fractures useful information?Material and methods We investigated 303 consecutive women patients between 55 and 75 years of age who had a newly diagnosed low-energy fracture. They answered a questionnaire on previous fractures which also dealt with risk factors. Bone mineral density (BMD) was measured at the hip, lumbar spine, and forearm.Results The distribution of fracture location was: distal forearm 56%, proximal humerus 12%, vertebra 18%, and hip 13%, all with similar age. Half of the subjects had had at least one previous fracture before the index fracture, 19% had had two previous fractures, and 6% had had three or more previous fractures. Patients with vertebral or hip fracture had lower BMD and had had more previous fractures than patients with forearm or humerus fractures. There was an inverse correlation between number of fractures and BMD. Osteoporosis was present in one-third of patients with forearm fracture, in one-half of those with hip or humerus fracture, and in two-thirds of those with vertebral fracture.Interpretation Vertebral fractures were the strongest marker of low BMD and forearm fractures the weakest. The number of previous fractures is helpful information for finding the most osteoporotic patient in terms of severity. Investigation of osteoporosis therefore seems

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“…We didn't forget that obesity can be associated with bone artrosis and that this factor can have a positive effect on BMD (43).…”

Section: Obesity and Postmenopausal Bone Densitymentioning

confidence: 99%

Influence of obesity on bone density in postmenopausal women

Silva

Mendonça

Conceição

et al. 2007

Arq Bras Endocrinol Metab

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Objective: To evaluate the influence of obesity, age, and years since menopause on bone density. Methods: A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before). Results: Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obese patients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD. Conclusion: The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis. Objetivo: Avaliar a influência de obesidade, idade e anos de menopausa sobre a densidade óssea. Métodos: Análise retrospectiva da densidade mineral óssea (DMO) obtida em 588 mulheres de 41 a 60 anos, já menopausadas (1-10 anos antes). Resultados: A influência positiva da obesidade foi confirmada através de diferenças significativas da DMO entre os grupos na coluna lombar (CL), colo de fêmur (CF) e trocânter (TR) (p < 0,01). Idade e anos desde a menopausa (ADM) foram correlacionados negativamente com DMO em todos os sítios (p = 0,000). Comparando-se pacientes entre 1 e < 6 ADM vs 6 e 10 AMD, a DMO foi maior no primeiro grupo na CL e CF (p < 0,005), apesar de maior DMO no grupo de mais idade (p = 0,01). Pacientes obesas tiveram uma prevalência mais baixa de osteoporose na CL e CF (p = 0,009). Análise de regressão identificou o IMC como o determinante mais forte da DMO de CF e trocânter, enquanto a ADM foi o determinante mais forte da DMO na CL. Conclusão: O efeito protetor da obesidade é sobrepujado pela deficiência de estradiol. Recomendamos que mesmo mulheres obesas na pós-menopausa devam ser examinadas para osteoporose.

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Influence of osteophytic size on bone mineral density measured by dual x-ray absorptiometry

Abstract: Our results indicate a nonlinear increase of measured BMD with increasing osteophytic size. These effects should be considered in routine examination and patient management.

Cited by 33 publications

References 19 publications

Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: The Rotterdam Study

Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: The Rotterdam Study

Women with low-energy fracture should be investigated for osteoporosis

Influence of obesity on bone density in postmenopausal women

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