Influence of Ovarian Ornithine Decarboxylase in Folliculogenesis and Luteinization

Bastida, C.M.; Cremades, Adolfo Díaz-Bautista; Castells, María Teresa; López-Contreras, Andrés J.; López‐García, Carlos; Tejada, Francisco; Peñafiel, Rafael

doi:10.1210/en.2004-1004

Cited by 38 publications

(30 citation statements)

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“…This level of ODC activity is at least 10 times that required for the preceding follicular phase, which is characterized by significant cell proliferation within the antral follicles (Kobayashi et al, 1971;Fozard et al, 1980b;Bastida et al, 2005), suggesting a function(s) unrelated to cell proliferation. Within the ovaries, LH stimulates the transitory rise of ODC proteins mainly in preovulatory follicles (Icekson et al, 1974), both in the somatic (theca and granulosa) cells and in the oocytes (Bastida et al, 2005). Complete inhibition of this transitory ODC/putrescine rise does not affect oocyte maturation or ovulation (Fozard et al, 1980b;Bastida et al, 2005).…”

Section: Introductionmentioning

confidence: 93%

“…On the other hand, the function of ODC during mammalian ovulation remains enigmatic (Lefevre et al, 2011). During estrous cycles in rats (Kobayashi et al, 1971) and mice (Bastida et al, 2005), ovarian ODC activity, and the corresponding ovarian putrescine concentration (Fozard et al, 1980b;Bastida et al, 2005) exhibit a LH-mediated transitory rise during the evening of proestrus, concurrent with oocyte maturation in vivo. This level of ODC activity is at least 10 times that required for the preceding follicular phase, which is characterized by significant cell proliferation within the antral follicles (Kobayashi et al, 1971;Fozard et al, 1980b;Bastida et al, 2005), suggesting a function(s) unrelated to cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…Within the ovaries, LH stimulates the transitory rise of ODC proteins mainly in preovulatory follicles (Icekson et al, 1974), both in the somatic (theca and granulosa) cells and in the oocytes (Bastida et al, 2005). Complete inhibition of this transitory ODC/putrescine rise does not affect oocyte maturation or ovulation (Fozard et al, 1980b;Bastida et al, 2005). It has been suggested that the transitory rise of ovarian ODC activity is required for luteinization of the granulosa cells to produce progesterone (Bastida et al, 2005), although gestation appears normal when the transitory ODC/putrescine rise is inhibited (Fozard et al, 1980b).…”

Section: Introductionmentioning

confidence: 99%

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Deficiency of ovarian ornithine decarboxylase contributes to aging‐related egg aneuploidy in mice

Tao

2012

Aging Cell

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SummaryIt has been known for more than four decades that during mammalian estrous cycles, luteinizing hormone stimulates a transitory rise in the ovaries of ornithine decarboxylase (ODC) activity and its enzymatic product putrescine, concurrent with oocyte maturation in vivo. Inhibition of this transitory ODC/ putrescine rise, however, does not appear to affect oocyte maturation or ovulation. Using several mouse models and combining in vitro and in vivo approaches, we demonstrated that deficiency of ODC during oocyte maturation is correlated with increased levels of egg aneuploidies. These results suggest that the transitory ovarian ODC rise in late proestrus is important for ensuring proper chromosome segregation during oocyte maturation. Older mice (8 months of age) exhibited about 1/3 that of young mice in LH-stimulated ovarian ODC activity and a corresponding increase in egg aneuploidies. Moreover, a combination of putrescine supplementation in mouse drinking water leading up to oocyte retrieval and in oocyte maturation medium reduced egg aneuploidies of the older mice from 12.7% to 5.3%. Therefore, ovarian ODC deficiency might be an important etiology of maternal aging-related aneuploidies, and peri-ovulatory putrescine supplementation might reduce the risk of aneuploid conceptions in older women.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deficiency of ovarian ornithine decarboxylase contributes to aging‐related egg aneuploidy in mice

Tao

2012

Aging Cell

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“…The homogenate was centrifuged at 12 000 g for 20 min, and DDC activity was determined in the supernatant by measuring 14 CO 2 release from 1-14 C DOPA, using a protocol similar to the one used for measuring ODC activity (Bastida et al 2005). In brief, the incubation mixture contained 20 mM Tris pH 7 .…”

Section: Measurement Of Ddc Activitymentioning

confidence: 99%

Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice

López-Contreras

Galindo²,

López‐García³

et al. 2007

Journal of Endocrinology

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3,4-Dihydroxyphenylalanine decarboxylase (DDC; also known as L-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein. In contrast to other amino acid decarboxylases that are modulated by sex hormones, little is known about the influence of these hormones on DDC regulation. In the present work, we studied the influence of gender in the expression of DDC in different mouse tissues. Among the different organs studied, including brain, liver, kidney, intestine, heart, adrenal gland, and skeletal muscle, only kidney and small intestine showed a sex-dependent dimorphism in DDC expression. In the kidney, levels of DDC activity, DDC mRNA, and protein were remarkably higher in females than in males. On the contrary, in the small intestine, male mice displayed higher levels of DDC activity than females but they did not correlate precisely with mRNA levels. This dimorphism was dependent on androgens, since male castration and treatment of female mice with testosterone propionate, oppositely affected DDC levels in kidney and small intestine. However, estrogen ablation or treatment with estradiol did not significantly affect DDC activity in these tissues. Immunocytochemical analysis revealed that DDC was mainly located in the proximal straight tubular cells of the kidney and in the cytoplasm of enterocytes. These data and the fact that renal DDC inversely correlated with renal sodium reabsorption suggest that renal and intestinal gender dimorphism in DDC could be related to sexrelated differences in sodium balance observed between males and females.

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“…Although it has been known for many years that pituitary and gonadal hormones induce ODC in target tissues (2,24,59), the physiological function of ODC induction in response to these factors still remains largely unknown. In this respect, we (7,8) recently found that the induction of ovarian ODC mediated by luteinizing hormone is necessary for folliculogenesis and luteinization. These studies suggested that ODC induction may be relevant for the regulation of the steroidogenic activity in the mouse ovary.…”

mentioning

confidence: 97%

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

Bastida¹,

Cremades²,

Castells³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Bastida CM, Cremades A, Castells MT, López-Contreras AJ, López-García C, Sánchez-Mas J, Peñ afiel R. Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. Am J Physiol Endocrinol Metab 292: E1010 -E1017, 2007. First published December 5, 2006; doi:10.1152/ajpendo.00316.2006.-Adrenal sexual dimorphism is thought to be important in explaining sex-related differences regarding prevalent diseases and the responses to stress and drugs. We report here that in CD1 mice there is marked sexual dimorphism affecting not only gland size and corticoid hormone secretion but also adrenal ornithine decarboxylase (ODC), polyamine, and catecholamine levels in which testosterone appears to be a major determinant. Our results show that adrenal weight, ODC activity, and corticosterone and aldosterone secretion were higher in female than in male mice and that orchidectomy brought these male parameters closer to the values found in females. mRNA levels of steroidogenic proteins SF-1, Dax-1, steroid 21-hydroxylase, and aldosterone synthase appeared to be slightly higher in female than in male adrenals. Immunocytochemical analysis of adrenal ODC revealed that immunoreactivity was higher in females than in males and was located mainly in the cortical cells, and especially in zona glomerulosa, whereas no sex differences in ODC mRNA levels were observed. These results suggest that sex-associated differences in the expression of ODC in the mouse adrenal gland appear to be related mainly to posttranscriptional mechanisms. Combination treatment of mice with ␣-difluoromethylornithine (a suicide inhibitor of ODC) and a polyamine-deficient diet produced a marked decrease in adrenal polyamine and catecholamine levels and a significant reduction in plasma corticosterone and aldosterone concentrations that were not associated with a decrease in the mRNA levels of steroidogenic proteins. All of these data suggest a relevant role for testosterone, ODC, and polyamines in the mouse adrenal function. mice; ␣-difluoromethylornithine; corticosterone; aldosterone; steroidogenesis THE ADRENAL GLAND plays an important role in stress response, with the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedulary system as the principal components (41). Considerable evidence has accumulated indicating that gonadal factors act as regulators of the hypothalamic-pituitary-adrenal axis and adrenal function. In the rat there is a marked sexual dimorphism in adrenal weight, plasma ACTH, and corticosterone concentrations, with females having higher values than males (1,25,27,30,45). This adrenal sexual dimorphism is thought to be an important factor in explaining sex differences in relation to prevalent diseases associated with hypothalamic-pituitary-adrenal axis reactivity, such as cardiovascular disease, inflammation, diabetes, and hypertension (19,55). On the other hand, it has been suggested that a transient increase in ornithine decarboxylase (ODC) activity and tissue p...

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Influence of Ovarian Ornithine Decarboxylase in Folliculogenesis and Luteinization

Cited by 38 publications

References 55 publications

Deficiency of ovarian ornithine decarboxylase contributes to aging‐related egg aneuploidy in mice

Deficiency of ovarian ornithine decarboxylase contributes to aging‐related egg aneuploidy in mice

Opposite sexual dimorphism of 3,4-dihydroxyphenylalanine decarboxylase in the kidney and small intestine of mice

Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels

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