Influence of p53 codon 72 exon 4, GSTM1, GSTT1 and GSTP1*B polymorphisms in lung cancer risk in a Brazilian population

Honma, Helen Naemi; Capitani, Eduardo Mello De; Perroud, Maurício W.; Barbeiro, Aristóteles S.; Toro, Ivan Felizardo Contrera; Costa, Daniel B.; Lima, Carmen Sílvia Passos; Zambon, Lair

doi:10.1016/j.lungcan.2007.12.014

Cited by 38 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Individuals with GST null polymorphism cannot detoxify carcinogenic metabolites efficiently. Moreover, the risk of cancer increases in these individuals in the presence of p53 codon 72 Pro allele, because it has lower potential to induce apoptosis (Honma et al, 2008). However, in the present study, results suggest that polymorphism of GST and p53 gene alone or in combination did not impart risk for AML development.…”

Section: Chauhan Et Alcontrasting

confidence: 66%

Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia

Chauhan

Ihsan

Yadav

et al. 2011

DNA and Cell Biology

View full text Add to dashboard Cite

Polymorphisms in genes encoding detoxification enzymes have been suggested as susceptibility factors for many solid tumors. However, their association with hematological malignancies is controversial. A case-control study was done to determine the association between glutathione S-transferase M1 (GSTM1), GSTT1, GSTP1, EPHX1, and p53 codon 72 polymorphisms as risk factors in 120 adult acute myeloid leukemia (AML) cases and 202 healthy controls by polymerase chain reaction-restriction fragment length polymorphism techniques. Data were analyzed using χ(2) and conditional logistic regression model. None of the polymorphisms studied alone was associated with increased risk for AML. However, the frequency of GSTT1 null genotype was higher among controls (28.7%) than AML cases (21.6%), which showed a protective effect of the null genotype (odds ratio = 0.58, 95% confidence interval: 0.33-1.05, p = 0.07). In a combined analysis, both EPHX1 (His113His) and GSTP1 (Ile/Val) genes imparted a fourfold risk for adult AML but did not reach statistical significance (odds ratio = 4.22, 95% confidence interval: 0.992-17.99, p = 0.05). These findings suggest that the etiology of adult AML cannot be explained by polymorphism at a single locus, perhaps because of complexity involved in the metabolism of diverse xenobiotic compounds, and therefore, multiple gene-gene interactions should be investigated to predict the risk of AML.

show abstract

Section: Chauhan Et Alcontrasting

confidence: 66%

Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia

Chauhan

Ihsan

Yadav

et al. 2011

DNA and Cell Biology

View full text Add to dashboard Cite

show abstract

“…Of these publications, three (Biros et al 2001a;Fan et al 2000;Murata et al 1996) were excluded because the same data were available in other studies (Biros et al 2001b;Miller et al 2002;Murata et al 1998). In three of the remaining 28 publications (Birgander et al 1995;Biros et al 2001a;Fernandez-Rubio et al 2008;Giuliani et al 2007;Hiraki et al 2003;Honma et al 2008;Irarrazabal et al 2003;Jain et al 2005;Jin et al 1995;Jung et al 2008;Liu et al 2001;Mechanic et al 2007;Miller et al 2002;Murata et al 1998;Nadji et al 2007;Papadakis et al 2002;Pierce et al 2000;Popanda et al 2007;Sakiyama et al 2005;Sreeja et al 2008;Szymanowska et al 2006;To-Figueras et al 1996;Wang et al 1999;Weston et al 1992;Weston et al 1994;Wu et al 2002;Zhang et al 2003;Zhang et al 2006), the ORs were presented separately according to the diVerent ethnicities: Mechanic et al (2007) sorted the data in African and Caucasian, respectively; Pierce et al (2000) presented the data according to Caucasian, Asian, and Mixed descent, respectively; and Jin et al (1995) presented the data according to African-American and Mexican-American, respectively. Therefore, each cohort in one publication was considered for pooling anal...…”

Section: Main Characteristicsmentioning

confidence: 99%

P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies

et al. 2009

View full text Add to dashboard Cite

To explore the real association between p53 codon 72 polymorphism and lung cancer risk, a pooled analysis of 32 case-control studies involving 19,255 subjects was conducted. When all 32 studies were pooled into the analysis, significantly elevated lung cancer risks were associated with variant genotypes in all genetic models (for Pro/Arg vs. Arg/Arg: OR 1.21, 95% CI 1.01-1.23; for Pro/Pro vs. Arg/Arg: OR 1.20, 95% CI 1.03-1.39; for Pro/Pro + Pro/Arg vs. Arg/Arg: OR 1.14, 95% CI 1.03-1.25; for Pro/Pro vs. Arg/Arg + Pro/Arg: OR 1.06, 95% CI 1.01-1.12). In the subgroup analysis by ethnicity, histological type, or smoking status, significantly increased risks were found in subgroups such as Asians, Caucasians, lung adenocarcinoma patients, or smokers, respectively. In conclusion, our results suggest that the Pro allele at p53 codon 72 is emerging as a low-penetrance susceptibility allele for lung cancer development.

show abstract

“…Table 1 presents the main characteristics of these studies. Among the 23 publications, 22 were published in English [9,[12][13][14]22,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43], and one was in Chinese [44]. The sample sizes ranged from 80 to 2424.…”

Section: Study Characteristicsmentioning

confidence: 99%

A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: Evidence from 15,857 subjects

Qiu

Shen

et al. 2009

Lung Cancer

View full text Add to dashboard Cite

Influence of p53 codon 72 exon 4, GSTM1, GSTT1 and GSTP1*B polymorphisms in lung cancer risk in a Brazilian population

Cited by 38 publications

References 41 publications

Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia

Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia

P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies

A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: Evidence from 15,857 subjects

Contact Info

Product

Resources

About