In aviation, the relative sliding between titanium alloy components causes varying degrees of wear. This work aimed at reducing abrasion between titanium alloy parts and improving their service life. Three different Ni-based coatings, WC-10Ni, Ni45, and NiCr coatings, are sprayed on the surface of Ti6Al4V alloy by HVOF. Test results of the mechanical and tribological properties of such coatings show that the hardness of the Ni45 and NiCr coatings are 673 HV0.1 and 438 HV0.1, respectively, which are lower than that of the WC-10Ni coating. When subjected to a high load, the Ni45 and NiCr coatings suffer a cracking of flat particle interfaces due to the low hardness, which lowers the fracture toughness more than that of the WC-10Ni coating. The specific wear rates of the coatings gradually decrease with the increase in the coating hardness and fracture toughness. However, the cutting of Ti6Al4V by the WC-10Ni coating and the adhesion of the NiCr coating to Ti6Al4V result in severe wear loss of the Ti6Al4V friction pair. The moderately hard Ni45 coating has a weaker cutting and adhesion effect on Ti6Al4V than the WC-10Ni and NiCr coatings, respectively, and the Ti6Al4V friction pair has the lowest wear loss. This study is a viable scheme for the design of wear-resistant coatings on titanium alloy surfaces and for improving the tribological properties between titanium alloy components.