Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Diniz, Fernanda Rodrigues; Frony-Macedo, Ana Lúcia; Piacenti-Silva, Marina

doi:10.21270/archi.v6i8.2214

Cited by 2 publications

(5 citation statements)

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“…In Italy, a study found significant relationships in the occurrence of MS relapses due to exposure to PM 10 [14]. A similar study was carried out in São Paulo city, Brazil, in which significant relationships were also found between MS relapses and PM 10 [5]. In addition to PM 10 , other pollutants may be related to MS relapses, such as sulfur dioxide (SO 2 ), nitrogen oxides (NO x ), and nitrogen dioxide (NO 2 ) [6,9,13].…”

Section: Introductionmentioning

confidence: 71%

“…A study in Italy showed that high concentrations of PM 10 are a risk factor of up to 46% for the occurrence of MS relapses [14]. Diniz et al [5] showed that there is a significant correlation between PM 10 and MS relapses in São Paulo city. PM 10 concentrations in São Paulo city frequently surpass the WHO standard levels.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the studies show a significant impact of air pollution on respiratory and cardiovascular diseases [3,4]. However, recent studies demonstrate the relationship between air pollution exposures and neuroinflammatory responses, which may be related to the development of diseases of the central nervous system such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis [5][6][7][8][9]. This study was conducted to investigate possible associations between air pollution and thermal discomfort and multiple sclerosis hospitalizations.…”

Section: Introductionmentioning

confidence: 99%

“…We are aware of only one previous study in Sao Paulo, Brazil, that related an air pollutant with multiple sclerosis relapses; however, in that study, only PM 10 was taken into consideration [5]. In this context, the objective of the current study was to investigate the associations between multiple atmospheric pollutants, including particulate matter less than 10 µm (PM 10 ), ozone (O 3 ), nitrogen dioxide (NO 2 ), nitrogen monoxide (NO), oxides of nitrogen (NO x ), and sulfur dioxide (SO 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Impacts of Air Pollution and Thermal Discomfort in Hospitalizations for Multiple Sclerosis in Sao Paulo, Brazil

Diniz,

Gonçalves,

Zilli Vieira

et al. 2023

Sclerosis

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Multiple sclerosis (MS) is an autoimmune, neurological, and demyelinating disease of unknown etiology. Neuroinflammation caused by the disease has been associated with air pollution as well as bioclimatic conditions. The aim of this study was to investigate the impacts of air pollution and human thermal discomfort on hospitalizations for multiple sclerosis in Sao Paulo, Brazil, from 2008 to 2015. Generalized Additive Model for Location Scale and Shape (GAMLSS) with Zero Inflated Poisson was used to relate multiple sclerosis hospitalizations in three age groups (less than 30 years old, between 30 and 50 years old, and more than 50 years old) and gender (female and male) with atmospheric pollutants PM10, SO2, NO2, NO, and NOx and thermal discomfort. The results showed that the exposure to an increase of 1 µg/m3 in SO2 concentration is highly associated with a 10% increase of the risk of MS hospitalization (95% CI: 2–21%) in female patients and a 7.5% (95% CI: 1.5–16%) increase in male patients. PM10 and NO were associated with increased MS risk only for female patients, mainly aged between 30 and 50 years old (2% and 1% increase in hospitalizations, respectively). The cold discomfort was also associated with MS hospitalization, mainly in males (2% increase in hospitalizations; 95% IC: 1–3%). These results are important, since there are few studies that relate air pollution and thermal discomfort with hospitalizations for multiple sclerosis in Brazil.

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Section: Introductionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impacts of Air Pollution and Thermal Discomfort in Hospitalizations for Multiple Sclerosis in Sao Paulo, Brazil

Diniz,

Gonçalves,

Zilli Vieira

et al. 2023

Sclerosis

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“…This finding is consistent with some of the studies and inconsistent with others. For examples, a Brazilian study found a positive correlation between RH and male MS admissions (r = 0.29, p < 0.01), while the correlation in females was insignificant (r = 0.04, p > 0.05) [23]. Further confusing the literature, an Iranian [17] and an Italian [24] study reported insignificant relationships between RH and MS.…”

Section: Discussionmentioning

confidence: 99%

Heat Exposure and Multiple Sclerosis—A Regional and Temporal Analysis

Chacko

Patel

2021

IJERPH

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Multiple sclerosis (MS) is a neurological disorder that progressively distorts the myelination of axons within the central nervous system (CNS). Increased core body temperature or metabolism as a result of exercise are common causes of short-term exacerbations of neurological symptoms in MS. About 60–80% of patients with MS experience a worsening of their symptoms when exposed to heat. In comparison, less data are available on the relationship between ambient meteorological conditions (e.g., temperature and relative humidity (RH)) and fluctuations in such variables in relation to MS symptoms. Thus, this study examined associations between time-lagged exposure to meteorological conditions and risk of a clinic visit due to MS among US veterans between 2010 and 2013. This study leveraged data from the Veterans Affairs (VA) and National Climactic Data Center (NCDC) for the continental US, partitioned into eight climate zones. We used a case crossover design to assess the risk of a MS clinic visit with respect to several meteorological conditions. Location-specific time-lagged daily (ambient) exposure to temperature, RH, and temperature variations (standard deviation (SD) of temperature) were computed (up to 30 days) for each case (i.e., day of MS visit) and control (a randomly assigned date ± 90–270 days prior to visit). Statistical analyses were conducted to examine independent associations between the selected meteorological conditions and risk of MS visits at the national and regional levels. A total of 533,066 patient visits received a MS diagnosis (International Classifications of Diseases (ICD)-9 code = 340). The Northeast (NE) and Upper Midwest (UMW) regions reported the highest frequency of clinic visits due to MS. Clinic visits were 9% more likely to occur in the spring, summer, and fall months (March–October) than in the winter (OR = 1.089; 95% CI = 1.076–1.103; p < 0.01). In the univariate analyses, the SD of temperature, temperature, and temperature–RH interaction were positively associated with an elevated risk of a MS clinic visit, while the RH was negatively associated with the risk for a clinic visit. In multivariate analyses, the strongest association of a MS clinic visit was observed with the SD of the temperature (OR = 1.012; 95% CI 1.008–1.017; p < 0.01). These associations between MS clinic visits and meteorological conditions varied across climate regions, with the strongest associations being observed in the LMW, UMW, DSW, and NE zones. The SD of the temperature was again the strongest associated predictor when examined regionally. Temperature variations and temperature–RH interactions (a proxy of the heat index) showed significant associations with MS clinic visits. These associations varied across climate regions when examined geographically. Our findings have implications for the management of MS in severe or recurrent cases, especially considering the impending changes in the daily temperature variations and intensity of the heatwaves expected with the intensification of global warming.

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Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Cited by 2 publications

References 16 publications

Impacts of Air Pollution and Thermal Discomfort in Hospitalizations for Multiple Sclerosis in Sao Paulo, Brazil

Impacts of Air Pollution and Thermal Discomfort in Hospitalizations for Multiple Sclerosis in Sao Paulo, Brazil

Heat Exposure and Multiple Sclerosis—A Regional and Temporal Analysis

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