Influence of Pentoxifylline and Interferon-Alpha on Prevention of Stricture due to Corrosive Esophagitis

Apaydin, Bedii Berat; Paksoy, Melih; Artiş, Tarık; Şahin, Dursun Ali; Akı, Hilal; Uslu, Ezel

doi:10.1159/000049710

Cited by 11 publications

(15 citation statements)

References 24 publications

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“…The value of pentoxy-fylline and alpha-interferon caustic oesophageal burns have been studied in the rat. In his work, Apaydin 14 indicated that these molecules prevents the formation of the oesophageal stricture in the rats oesophagus which was burned by instilling, 37.5% sodium hydroxide (Na OH)and rinsed with physiological serum for 90 seconds. It is possible that by extrapolation these substances may be valuable in preventing esophageal burns in the humans when applied early.Esophageal strictures may be managed by pneumatic or instrumental dilatation.…”

Section: Discussionmentioning

confidence: 99%

Caustic stenosis of the oesophagus at Centre Hôpital D’Université(CHU) of Lome :Epidemiological and therapeutic aspects

Attipou¹,

Dossed²,

Abousalem³

et al. 2010

Nigerian Journal of Surgical Research

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Objective: The purpose of this study, was studying of the epidemiological factors and the results of management of these caustic stenosis of the oesophagus. Material And Method: A retrospective study. 38 cases of caustic stenosis of the oesophagus were, admitted and treated at the surgical departments of CHU of Lome, Togo, during the period January 1 st 1983 to 31st December 2004. Result: The caustic stenosis of the oesophagus represented the second most common oesophageal disease treated at the surgical department [ 38/15153(24.84%)]. 21 were male and 17 female. Caustic soda was the commonest substance ingested (14 cases / 38). Suicide was the most frequent reason for ingestion of caustic substances. The majority of our patients 28(71.05%) had early surgical intervention. The others were managed by endoscopy. The overall outcome was satisfactory in 37 cases. One patient died in this study. After a follow-up of a median of 7 years, four patients re-presented a moderate residual dysphagia. Conclusion: This caustic stenosis of the oesophagus represents a disease with an increasing frequency inside our societies. Adequate measures must be carried out to prevent the caustic burns of the oesophagus among our peoples.

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Section: Discussionmentioning

confidence: 99%

Caustic stenosis of the oesophagus at Centre Hôpital D’Université(CHU) of Lome :Epidemiological and therapeutic aspects

Attipou¹,

Dossed²,

Abousalem³

et al. 2010

Nigerian Journal of Surgical Research

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“…Vitamin E (a-tocopherol) is a lipid-phase, non-enzymatic antioxidant that stabilises the unsaturated fatty acids of the cell membrane, protecting [7,14,19,31,32]. Esophageal tissue with acid and/or alkali burns treated with vitamin E, therefore, is likely to have an increased ability to scavenge FOR and to be protected against lipid peroxidation in the membrane [33].…”

Section: Discussionmentioning

confidence: 99%

“…All stained specimens were evaluated and scored under light microscopy. Inflammation levels were determined for the acute phase specimens, and collagen deposition on the esophageal wall was evaluated semiquantitatively for the late phase specimens [1,9,14].…”

Section: Histopathologic Assaysmentioning

confidence: 99%

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Biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns

et al. 2008

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The aim of the study reported here was to evaluate the biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns. A total of 144 Wistar Albino rats were divided into 12 experimental groups (12 rats per group) and used in an animal study. Group I rats were given a laparotomy and received no treatment (control group), while groups II, III and IV received a laparotomy and were treated with omeprazole, vitamin E or omeprazole/vitamin E, respectively. Groups V-XII rats received a laparotomy and were given a caustic acid burn through acid instillation (1 ml caustic 10% sulphuric acid; groups V-VIII) or alkali instillation (corrosive 10% sodium hydroxide solution; groups IX-XII) into the isolated esophageal segment via a 22-Fr cannula for 2 min. Each group of rats subjected to caustic burn received either no treatment (groups V and IX) or were treated with omeprazole, vitamin E or omeprazole/vitamin E, respectively (remaining six groups). Omeprazole (20 mg/kg) or vitamin E (10 mg/kg) was administered to the rats intraperitoneally or intramuscularly, respectively. Seventy-two rats (50% of each group, n = 6) were killed immediately after the experimental treatment (acute phase). The remaining rats were kept under standard conditions for 21 days (late phase) before being killed. The distal esophageal segments were harvested from all animal and used in histopathologic and biochemical analyses. Compared to the controls (no caustic burn), rats receiving only the acid or alkali installation (and no subsequent treatment) had the highest mean malondialdehyde (16.9 and 15.8 micromol MDA/g protein, respectively) and hydroxyproline (5.9 and 5.7; mg HP/g wet tissue) levels of all groups. In comparison, rats treated with acid + omeprazole and/or vitamin E had relatively lower MDA (12.9 and 11.6 micromol/g protein, respectively) and HP levels (4.3 and 4.08 mg/g wet tissue, respectively). Similarly, rats treated with alkali + omeprazole and/or vitamin E had low levels of MDA (13.9 and 11.7 micromol/g protein, respectively) and HP (4.3 and 4.4 mg/g wet tissue, respectively). The glutathione (GSH) levels of acid-only- or alkali-only-treated rats were lower than those found in omeprazole- and/or vitamin E-treated rats. Based on these results, we conclude that vitamin E and omeprazole affect the biochemical and histopathologic parameters in rats receiving corrosive esophageal burn from acid and alkali. The effect of both substances was slightly greater in the acid-treated groups.

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“…Role of free oxygen radicals in pathogenesis of inflammation is well recognized. Pentoxifylline (PTX) is a methylxanthine derivative with antioxidant, antiinflammatory, and immunomodulator effects [17,18]. 5-fluorouracil (5-FU) is an antineoplastic agent which inhibits fibroblast proliferation and wound healing.…”

Section: Introductionmentioning

confidence: 99%

Effect of pentoxifylline and 5-fluorouracil/triamcinolone on laryngotracheal stenosis developing as a complication of tracheostomy: study in rats

Koç

Kiyici

Söğüt

et al. 2012

Eur Arch Otorhinolaryngol

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We aimed to investigate the prophylactic effect of pentoxifylline (PTX) and 5-fluorouracil (5-FU) on laryngotracheal stenosis in tracheotomised rats by evaluating blood glutathione peroxidase (GPx) and superoxide dismutase activities and by histopathological evaluation of laryngotracheal segment. Randomized prospective single-blind study. Standard vertical tracheotomy was performed on 24 rats. Then, the animals were randomly divided into three groups. Intraperitoneal PTX administered to group A (study group) for 10 days. 5-FU was injected in paratracheal tissues in group B (study group) for 10 days. In group C (control group), intraperitoneal saline was administered for 10 days. After 10 days, tracheal cannules were removed. For biochemical analysis, two blood samples were obtained. Three weeks later, all animals were euthanized and trachea specimens were harvested. Stenosis index and mean wall thickness in PTX group were lower as compared to other groups but the difference was statistically insignificant. Minimum inflammation and fibrosis plus maximum epithelial regeneration were seen in PTX group. In addition, GPx activity was at highest level in PTX group and a statistically significant difference was found between control and PTX groups (P = 0.024) though the difference between remaining groups was statistically insignificant (P = 0.121). Superoxide dismutase activity was highest in PTX group but no statistically significant difference was found between the three groups (P = 0.305). The administration of PTX increases GPx activity and it may have some effect on tracheal scar formation which develops following tracheostomy.

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Influence of Pentoxifylline and Interferon-Alpha on Prevention of Stricture due to Corrosive Esophagitis

Cited by 11 publications

References 24 publications

Caustic stenosis of the oesophagus at Centre Hôpital D’Université(CHU) of Lome :Epidemiological and therapeutic aspects

Caustic stenosis of the oesophagus at Centre Hôpital D’Université(CHU) of Lome :Epidemiological and therapeutic aspects

Biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns

Effect of pentoxifylline and 5-fluorouracil/triamcinolone on laryngotracheal stenosis developing as a complication of tracheostomy: study in rats

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