Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study

Kurgan, Şivge; Önder, Canan; Balcı, Nur; Akdoğan, Nihan; Altıngöz, S. Merve; Serdar, Muhittin; Günhan, Meral

doi:10.1007/s00784-022-04528-4

Cited by 9 publications

(19 citation statements)

References 61 publications

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“…[36][37][38] Our previous study demonstrated that KP is crucial for the etiopathogenesis of periodontal diseases. 14 In the literature, it was shown that smoking has impacts on KP. 18,19,39 Based on this information, in this study, the influence of smoking and periodontal inflammation on salivary and serum TRP-KYN metabolism was investigated and it was revealed that the KYN/TRP ratio was significantly decreased in saliva in association with periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, we have demonstrated that serum KYN/TRP ratio was higher in periodontitis patients. 14 In the current study, we investigated the alterations in TRP and its metabolites on both salivary and serum samples in smokers with periodontitis. Saliva is useful because it is plentiful and easily accessible via noninvasive techniques.…”

Section: Discussionmentioning

confidence: 99%

“…13 Furthermore, in our previous study, we demonstrated that KP may be crucial to the pathophysiology and development of periodontal disease. 14 We evaluated the TRP, KYN, and KYN metabolites between nonsmoker stage III periodontitis patients and periodontally healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

“…The results of this study revealed that salivary TRP, KYN, KYN metabolites, and serum KYN, KYN/TRP ratio were significantly higher in periodontitis patients than in healthy controls. 14 So it is possible to serve as a predictive biomarker of KP for these conditions. Indoleamine 2,3-dioxygenase (IDO) is the first rate-limiting enzyme in KP, which catalyzes tryptophan.…”

Section: Introductionmentioning

confidence: 99%

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Does smoking influence tryptophan metabolism in periodontal inflammation? A cross‐sectional study

Önder

Akdoğan

Kurgan

et al. 2023

J of Periodontal Research

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ObjectivesThe aim of this study was to identify the effects of smoking and periodontal inflammation on tryptophan‐kynurenine metabolism as well as the correlation between these findings and clinical periodontal parameters.BackgroundIt has been shown that the tryptophan amino acid's primary catabolic pathway, the kynurenine pathway (KP), may serve as a key biomarker for periodontal disease. Although there are studies investigating the effect of smoking on KYN‐TRP metabolism, the effect of smoking on periodontal disease through KP has not been revealed so far.MethodsThe salivary and serum samples were gathered from 24 nonsmoker (NS‐P) stage III, grade B generalized periodontitis and 22 smoker (S‐P) stage III, grade C generalized periodontitis patients, in addition to 24 nonsmoker (NS‐C) and 24 smoker (S‐C) periodontally healthy control individuals. Saliva and serum IL‐6, kynurenine (KYN), and tryptophan (TRP) values, and KYN/TRP ratio were analyzed by liquid chromatography‐mass spectrometry. Clinical periodontal measurements were recorded.ResultsSalivary TRP values were significantly higher in both periodontitis groups than control groups (p < .05). Salivary KYN values were highest in NS‐P group (p < .05). Salivary KYN values did not differ significantly between periodontitis groups (p = .84). Salivary KYN/TRP ratio was significantly lower in NS‐P group compared to other groups (p < .001). Serum TRP value is higher in S‐P group than other groups; however, significant difference was found in S‐C group (p < .05). Serum KYN values were significantly lower in smokers than nonsmokers. Serum KYN/TRP ratio is higher in NS‐P group. NS‐P group has the highest salivary IL‐6 levels, NS‐C group has the lowest values (p < .05).ConclusionsOur results point out that smoking exacerbates inflammation in the periodontium and increases TRP destruction and decreases IDO activity by suppressing KP in serum. As a result, kynurenine and its metabolites may be significant biomarkers in the link between smoking and periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does smoking influence tryptophan metabolism in periodontal inflammation? A cross‐sectional study

Önder

Akdoğan

Kurgan

et al. 2023

J of Periodontal Research

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“…Within skeletal muscle and other tissues, KYN is metabolized into kynurenic acid (KYNA), anthranilic acid (AA), and xanthurenic acid (XANA), quinolinic acid (QA), 3-hydroxy- l -KYN (3-HK) and picolinic acid (PA), and an increase in KYN serum levels has been observed after different types of exercise [ 1 , 2 ]. On the other hand, one of the characteristics of adaptation to endurance training is the increased expression of KYN aminotransferases (KATs), which catalyze the conversion of KYN to KYNA [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism

et al. 2022

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In humans, most free tryptophan is degraded via kynurenine pathways into kynurenines. Kynurenines modulate the immune system, central nervous system, and skeletal muscle bioenergetics. Consequently, kynurenine pathway metabolites (KPMs) have been studied in the context of exercise. However, the effect of vitamin D supplementation on exercise-induced changes in KPMs has not been investigated. Here, we analyzed the effect of a single high-dose vitamin D supplementation on KPMs and tryptophan levels in runners after an ultramarathon. In the study, 35 amateur runners were assigned into two groups: vitamin D supplementation group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run (n = 16); and control (placebo) group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Kynurenic, xanthurenic, , quinolinic, and picolinic acids levels were significantly increased after the run in the control group, but the effect was blunted by vitamin D supplementation. Conversely, the decrease in serum tryptophan, tyrosine, and phenylalanine levels immediately after the run was more pronounced in the supplemented group than in the control. The 3-hydroxy-l-kynurenine levels were significantly increased in both groups after the run. We conclude that vitamin D supplementation affects ultramarathon-induced changes in tryptophan metabolism.

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Salivary irisin level is higher and related with interleukin-6 in generalized periodontitis

et al. 2023

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Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study

Cited by 9 publications

References 61 publications

Does smoking influence tryptophan metabolism in periodontal inflammation? A cross‐sectional study

Does smoking influence tryptophan metabolism in periodontal inflammation? A cross‐sectional study

Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism

Salivary irisin level is higher and related with interleukin-6 in generalized periodontitis

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