Influence of Periodontitis in the Development of Nosocomial Pneumonia: A Case Control Study

Filho, Isaac Suzart Gomes; Oliveira, Thaís Feitosa Leitão de; Cruz, Simone Seixas da; Passos‐Soares, Johelle de Santana; Trindade, Soraya Castro; Oliveira, Michelle Teixeira; Souza‐Machado, Adelmir; Cruz, Álvaro Augusto; Barreto, Maurício Lima; Seymour, G. J.

doi:10.1902/jop.2013.130369

Cited by 43 publications

(45 citation statements)

References 34 publications

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“…4 Severe asthma is characterized by the presence of daily symptoms necessitating the use of bronchodilators, incapacity, emergency hospital visits, repetitive use of systemic corticosteroids, and diminished pulmonary function. 5,7 Diseases caused by viral and bacterial infections, 7-10 as well as chronic diseases, such as periodontitis, 3,11,12 can provoke the exacerbation of bronchial inflammation, disrupted mucociliary transport, and increased mucus production, which can worsen asthma. 5,6 Several microorganisms have been related to the pathogenicity of asthma as these play an important role in respiratory disorders and can modulate the heterogeneity of this health condition.…”

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confidence: 99%

Prevotella intermedia and periodontitis are associated with severe asthma

Lopes

Cruz

Xavier

et al. 2019

Journal of Periodontology

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Background Periodontitis, an inflammatory disease of multibacterial etiology that affects the protective and supporting tissues surrounding teeth, can influence the course of respiratory diseases, such as asthma, due to epithelial alterations arising from inflammatory and immunological processes, bronchial remodeling, or by the aspiration of pathogenic colonizers found in periodontal pockets. This study evaluated the levels of periodontal pathogens Prevotella intermedia, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans in the subgingival biofilm of individuals with and without severe asthma. Methods A case‐control study enrolling 457 individuals (220 with asthma and 237 without asthma) was conducted at the Program for Control of Asthma in Bahia (ProAR) Clinic located in Salvador, Bahia, Brazil. A structured questionnaire was used to obtain data on sociodemographic, health status, and lifestyle habits. A clinical periodontal assessment was performed, including bleeding on probing, probing depth, and clinical attachment level. Subgingival biofilm was collected at the deepest site of each sextant, and bacterial DNA was extracted. Quantitative real‐time PCR analysis was performed to detect and relatively quantify periodontopathogens in the biofilm. Results Statistically significant positive associations were found between periodontitis and severe asthma, (odds ratio [OR]adjusted]: 4.00; 95% confidence interval [CI]: 2.26 to 7.10). High levels of P. intermedia were found in association with the presence of severe asthma (ORadjusted: 2.64; 95% CI: 1.62 to 4.39; P < 0.01). Conclusions The present results suggest that periodontitis and P. intermedia are associated with severe asthma. However, the functional consequences of this dysbiosis upon asthma susceptibility and its phenotypes remain unclear.

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confidence: 99%

Prevotella intermedia and periodontitis are associated with severe asthma

Lopes

Cruz

Xavier

et al. 2019

Journal of Periodontology

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“…Conversely, other features strengthen the method, lending more quality to the study and granting it internal validity. The cutoff point established by the World Health Organization classification was used to define LBW, 20 and the criteria used for the classification of periodontal disease has good specificity and has been used in many other studies linking periodontitis to systemic conditions 23,28,34‐39 . In this context, given the current evidence on reference values for gestational glycemic levels and the findings of this study that showed the overshadowing influence of maternal glycemic level in the relationship between periodontitis and LBW, mainly in mothers with an HbA1c <5.6 but also in those with an HbA1c ≥5.6 and <6.5%, it is important to highlight the need for accurate glycemic levels when studying the oral health status of females during pregnancy.…”

Section: Discussionmentioning

confidence: 85%

Relationship Among Mothers’ Glycemic Level, Periodontitis, and Birth Weight

Filho

Pereira

Cruz

et al. 2016

Journal of Periodontology

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“…Observational studies have indicated that the presence of periodontal pathogens in dental plaque is related to the incidence of aspiration pneumonia (Terpenning et al., , ). Case–control studies have demonstrated that chronic periodontal disease, based on clinical examination, is associated with pneumonia (de Melo Neto et al., ; Gomes‐Filho et al., ). In addition, studies have shown that periodontal pathogens such as Porphyromonas gingivalis can cause lung inflammatory responses and pneumonia in an animal model (Kimizuka, Kato, Ishihara, & Okuda, ).…”

Section: Discussionmentioning

confidence: 99%

Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study

Iwasaki

Taylor

Awano

et al. 2017

J Clinic Periodontology

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Aim: To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients. Materials and Methods:This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing-risks regression model. Results:At baseline, 92 patients (43.6%) had periodontal disease. The median followup period was 84 months (interquartile range, 36-86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing-risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14-10.64), after adjusting for other baseline health characteristics. Conclusions:The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest. K E Y W O R D Scohort studies, epidemiology, kidney diseases, oral health, periodontitis, renal dialysis

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Influence of Periodontitis in the Development of Nosocomial Pneumonia: A Case Control Study

Abstract: These findings suggest that periodontal infection may influence the development of NP, highlighting that periodontitis is a factor positively associated with this respiratory tract infection.

Cited by 43 publications

References 34 publications

Prevotella intermedia and periodontitis are associated with severe asthma

Prevotella intermedia and periodontitis are associated with severe asthma

Relationship Among Mothers’ Glycemic Level, Periodontitis, and Birth Weight

Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study

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