Influence of pH-responsive compounds synthesized from chitosan and hyaluronic acid on dual-responsive (pH/temperature) hydrogel drug delivery systems of Cortex Moutan

Chatterjee, Sudipta; Chiu, Patrick; Siu, Wing Sum; Kan, Chi Wai; Leung, Ping Chung; Chen, Wan-Xue; Chiou, Jiachi

doi:10.1016/j.ijbiomac.2020.12.035

Cited by 51 publications

(19 citation statements)

References 42 publications

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“…The modifiability of the functional groups leads to their ability to be tailored to the desired mechanical strength and functionality. Many pH-responsive compounds based on CS are extensively applied in transdermal drug delivery [ 36 , 37 ]. In addition, it is considered a potential antifungal drug because of its biocompatibility, biodegradability, non-toxicity, hemostatic activity, and antibacterial and antimycotic properties [ 38 , 39 , 40 ].…”

Section: Polysaccharidementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

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Section: Polysaccharidementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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“…The transdermal experiments at different temperatures indicated that the drug carriers on the bio-functional textiles could give sustained and controlled release of procaine [ 81 ]. Our research team had developed some LCST-type PF127-based drug delivery systems to treat skin diseases such as atopic dermatitis via textile-based transdermal therapy [ 16 , 25 , 28 , 29 ]. PF127-based stimuli-responsive hydrogels showed transdermal delivery of Cortex Moutan and exhibited sol–gel transitions around 37 °C [ 29 ].…”

Section: Future Prospects Of Thermo-responsive Biopolymersmentioning

confidence: 99%

“…Our research team had developed some LCST-type PF127-based drug delivery systems to treat skin diseases such as atopic dermatitis via textile-based transdermal therapy [ 16 , 25 , 28 , 29 ]. PF127-based stimuli-responsive hydrogels showed transdermal delivery of Cortex Moutan and exhibited sol–gel transitions around 37 °C [ 29 ]. The thermo-responsive hydrogels made of PF127 and carboxymethyl cellulose sodium worked as a drug delivery system of traditional Chinese medicine, Cortex Moutan and supplied moisture to the skin as well [ 25 ].…”

Section: Future Prospects Of Thermo-responsive Biopolymersmentioning

confidence: 99%

“…The PF127-based dual-responsive hydrogels (with/without) loaded Cortex Moutan showed low cytotoxicity on human HaCaT keratinocytes, and the cell viability was just above 80.0% within the concentration range of 0.0–20.0 μg/mL [ 28 ]. The PF127-based hydrogel with loaded Cortex Moutan (Traditional Chinese medicine) did not show cytotoxicity on human HaCaT keratinocytes within the concentration range of 0.0–20.0 μg/mL, but these hydrogel formulations were found to be slightly cytotoxic without being drug-loaded [ 29 ]. The PF127-based micelles exhibited low cytotoxicity on the Bel 7402 and L02 cells, and the cell viability was just above 85.0% within the concentration range of 12.5–200.0 μg/mL [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Review of Applications and Future Prospects of Stimuli-Responsive Hydrogel Based on Thermo-Responsive Biopolymers in Drug Delivery Systems

Chatterjee

Chiu

2021

Polymers

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Some of thermo-responsive polysaccharides, namely, cellulose, xyloglucan, and chitosan, and protein-like gelatin or elastin-like polypeptides can exhibit temperature dependent sol–gel transitions. Due to their biodegradability, biocompatibility, and non-toxicity, such biomaterials are becoming popular for drug delivery and tissue engineering applications. This paper aims to review the properties of sol–gel transition, mechanical strength, drug release (bioavailability of drugs), and cytotoxicity of stimuli-responsive hydrogel made of thermo-responsive biopolymers in drug delivery systems. One of the major applications of such thermos-responsive biopolymers is on textile-based transdermal therapy where the formulation, mechanical, and drug release properties and the cytotoxicity of thermo-responsive hydrogel in drug delivery systems of traditional Chinese medicine have been fully reviewed. Textile-based transdermal therapy, a non-invasive method to treat skin-related disease, can overcome the poor bioavailability of drugs from conventional non-invasive administration. This study also discusses the future prospects of stimuli-responsive hydrogels made of thermo-responsive biopolymers for non-invasive treatment of skin-related disease via textile-based transdermal therapy.

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“…Controlled drug release, vital for pharmaceutical therapies in healthcare, is a dynamic, either pulsatile or extended-release of active compounds to avoid side effects and maintain a constant, topical, or plasma level of the medication in chronic diseases [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

et al. 2022

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(1) Background: The standard treatment for periodontal disease, a chronic inflammatory state caused by the interaction between biofilms generated by organized oral bacteria and the local host defense response, consists of calculus and biofilm removal through mechanical debridement, associated with antimicrobial therapy that could be delivered either systemically or locally. The present study aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a carrier for the controlled release of the active compounds of a formulation proposed as a topical treatment for periodontal disease, and the influence of pH on the complex system’s stability. (2) Methods: The obtained hyaluronic acid (HA) hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis, UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and dielectric analysis. The MTT viability test was applied to check the cytotoxicity of the obtained membranes, while the microbiological assessment was performed against strains of Staphylococcus spp. and Streptococcus spp. The spectrophotometric investigations allowed to follow up the release profile from the HA matrix for MEL, MZ, and T present in the topical treatment considered. We studied the behavior of the active compounds against the pH of the generated environment, and the release profile of the bioactive formulation based on the specific comportment towards pH variation. The controlled delivery of the bioactive compounds using HA as a supportive matrix was modeled applying Korsmeyer–Peppas, Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order kinetic model. (3) Results: It was observed that MZ and T were released at higher active concentrations than MEL when the pH was increased from 6.75, specific for patients with periodontitis, to a pH of 7.10, characterizing the healthy patients. Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 × 10−5 mol/L followed by a release decrease, while for MEL and T a short release plateau was recorded up to a concentration of 1.80 × 10−5 mol/L for MEL and 0.90 × 10−5 mol/L for T, followed by a continuous release; (4) Conclusions: The results are encouraging for the usage of the HA membrane matrix as releasing vehicle for the active components of the proposed topical treatment at a physiological pH.

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Influence of pH-responsive compounds synthesized from chitosan and hyaluronic acid on dual-responsive (pH/temperature) hydrogel drug delivery systems of Cortex Moutan

Cited by 51 publications

References 42 publications

Polysaccharide-Based Transdermal Drug Delivery

Polysaccharide-Based Transdermal Drug Delivery

Review of Applications and Future Prospects of Stimuli-Responsive Hydrogel Based on Thermo-Responsive Biopolymers in Drug Delivery Systems

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

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