Influence of photoactivated tetra sulphonatophenyl porphyrin and TiO<sub>2</sub>nanowhiskers on rheumatoid arthritis infected bone marrow stem cell proliferation in vitro and oxidative stress biomarkers in vivo

Rehman, Fawad Ur; Zhao, Chunqiu; Wu, Chang-Yu; Jiang, Hui; Selke, Matthias; Wang, Xuemei

doi:10.1039/c5ra23480h

Cited by 12 publications

(3 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biocompatible magnetic fluids consist of ferrite nanoparticles dispersed as a magnetic colloid that may also be used for local magnetic hyperthermia therapy (HPT). , HPT uses an external alternating magnetic field to promote an increase in local temperature (∼42–44 °C) and then cause the preferential destruction of cells and tissues. − Recently, it has been suggested that the combination of porphyrins with nanocomposites could potentially be used as diagnostic and/or therapeutic agents for tumors and other diseases. , Nowostawska et al synthesized a new multimodal (magnetic and fluorescent) porphyrin-magnetite nanoconjugate for biological imaging. Zhao et al. − used a new nanocomposite of TPPS porphyrin with TiO 2 nanowhiskers as effective bioimaging and photodynamic therapeutic agents for rheumatoid arthritis theranostics. Besides, TPPS encapsulated into the ZnO nanomaterials have increased the generation of singlet oxygen and the photobactericidal activity of ZnO nanorods …”

Section: Introductionmentioning

confidence: 99%

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

et al. 2017

View full text Add to dashboard Cite

Modern medicine has been searching for new and more efficient strategies for diagnostics and therapeutics applications. Considering this, porphyrin molecules have received great interest for applications in photodiagnostics and phototherapies, even as magnetic nanoparticles for drug-delivery systems and magnetic-hyperthermia therapy. Aiming to obtain a multifunctional system, which combines diagnostics with therapeutic functions on the same platform, the present study employed UV/vis absorption and fluorescence spectroscopies to evaluate the interaction between meso-tetrakis(p-sulfonatofenyl)porphyrin (TPPS) and maghemite nanoparticles (γ-FeO). These spectroscopic techniques allowed us to describe the dynamics of coupling porphyrins on nanoparticles and estimate the number of 21 porphyrins per nanoparticle. Also, the binding parameters, such as the association constants (K = 8.89 × 10 M) and bimolecular quenching rate constant (k = 2.54 × 10 M s) were obtained. These results suggest a static quenching process where the electrostatic attraction plays an essential role. The work shows that spectroscopic techniques are powerful tools to evaluate the coupling of organic molecules and nanoparticles. Besides, the system studied provides a relevant background for potential applications in bionanotechnology and nanomedicine, such as (1) nanodrug delivery system, (2) photodiagnostics/theranostics, and/or (3) a combined action of photodynamic and hyperthermia therapies, working in a synergetic way.

show abstract

Section: Introductionmentioning

confidence: 99%

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…TSPP enters the cell via endocytosis and localizes in cellular organelle (lysosomes, endosomes, and endoplasmic reticulum) where it interferes with cellular signal pathways, thus producing apoptosis or necrosis (Høgset et al 2004 ; Berg et al 2011 ). Rehman et al ( 2015 , 2016b ) studied the protective effect of TiO 2 nanowhiskers (TiO 2 NWs)–TSPP complex in vitro and in vivo. TSPP–TiO 2 NWs were prepared by mixing TSPP and TiO 2 together.…”

Section: Titanium Dioxide Nanoparticles (Tio 2 Npsmentioning

confidence: 99%

The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy

et al. 2017

View full text Add to dashboard Cite

Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are commonly reported. In addition, graphene has also been reported to be used as NPs albeit being relatively new to this field. In this context, the present review is organized by these different NPs and contains numerous research works related to PDT applications. The effectiveness of these NPs for PDT is discussed in detail by collecting all essential information described in the literature. The information thus assembled could be useful in designing new NPs specific for PDT and/or PTT applications in the future.

show abstract

“…During autoimmune diseases, such as RA, an altered functionality of autoimmune cells (B lymphocytes) may also influence the adjacent cells. 43 Hence, the bone marrow microenvironment is affected, leading to altered physiology and functionality of bone that ultimately leads to bone erosion and associated conditions.…”

Section: Introductionmentioning

confidence: 99%

Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology

Bao²,

Zeng³

et al. 2019

Bone Res

Self Cite

View full text Add to dashboard Cite

Autoimmune diseases are affected by complex pathophysiology involving several cell types, cytokines, antibodies, and mimicking factors. Different drugs are used to ameliorate these autoimmune reactions, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antiantibodies, and small molecular drugs (DMARDs), and they are clinically in vogue for diseases such as rheumatoid arthritis (RA). Nevertheless, low cost-effectiveness, reduced efficacy, adverse effects, and patient nonresponse are unappealing factors driving the development of new drugs such as iguratimod. Iguratimod is primarily used to ameliorate RA in Japanese and Chinese clinics. However, its efficacy against other autoimmune ailments is also under intense investigation, and the number of investigations is becoming increasingly larger with each passing day. The articular structure comprises synovium, ligaments, and bone. The latter is more complex than the others since it regulates blood cells and autoimmunity in addition to providing skeletal support to the body. Therefore, its protection is also of prime importance in RA and other autoimmune diseases. Herein, we have highlighted the role of iguratimod in autoimmune diseases and bone protection. We suggest that iguratimod's unique mode of action compared with that of other DMARDs and its good patient response makes it a suitable antirheumatic and bone-protecting drug.Bone Research (2019) 7:27 ; https://doi.Fig. 2 Effects of iguratimod and other DMARDs on collagen-induced arthritis. a Arthritis score in different DMARD-treated groups. b Arthritis incidence of different treated groups. c The extent of paw edema in various groups. d The body weight measured in various groups after DMARD treatment. e X-ray radiographs of various groups treated with different DMARDs. Arrows indicate the bone erosion area, whereas * and ** indicate significance P-values of <0.05 and 0.01 (*P < 0.05, **P < 0.01), respectively. Adapted from Ref. 21

show abstract

Influence of photoactivated tetra sulphonatophenyl porphyrin and TiO₂nanowhiskers on rheumatoid arthritis infected bone marrow stem cell proliferation in vitro and oxidative stress biomarkers in vivo

Abstract: Besides the lethal effects of photodynamic therapy on neoplasms, herein we report photoactivated TSPP–TiO2nanocomposites' growth promoting effect on rheumatoid arthritis BMS cells.

Cited by 12 publications

References 60 publications

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy

Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology

Contact Info

Product

Resources

About

Influence of photoactivated tetra sulphonatophenyl porphyrin and TiO2nanowhiskers on rheumatoid arthritis infected bone marrow stem cell proliferation in vitro and oxidative stress biomarkers in vivo

Abstract: Besides the lethal effects of photodynamic therapy on neoplasms, herein we report photoactivated TSPP–TiO2nanocomposites' growth promoting effect on rheumatoid arthritis BMS cells.

Cited by 12 publications

References 60 publications

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

Use of Spectroscopic Techniques for Evaluating the Coupling of Porphyrins on Biocompatible Nanoparticles. A Potential System for Photodynamics, Theranostics, and Nanodrug Delivery Applications

The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy

Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology

Contact Info

Product

Resources

About

Influence of photoactivated tetra sulphonatophenyl porphyrin and TiO₂nanowhiskers on rheumatoid arthritis infected bone marrow stem cell proliferation in vitro and oxidative stress biomarkers in vivo