Influence of Physical Parameters and Lubricants on the Compaction Properties of Granulated and Non-granulated Cross-linked High Amylose Starch.

Rahmouni, Miloud; Lenaerts, Vincent; Massuelle, Danielle; Doelker, Éric; Leroux, Jean‐Christophe

doi:10.1248/cpb.50.1155

Cited by 18 publications

(16 citation statements)

References 30 publications

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“…Cross-linked high amylose starch matrix obtained from powder compaction has been characterized as a porous material. 30,31 After swelling, it has been demonstrated that Contramid matrix remains porous and acts like a sponge through which water is able to flow under physical stress. 32 Usually, implantation of a porous biomaterial does not induce a dense fibrous capsule 22,33,34 and enables a better vascular invasion of the polymer bulk.…”

Section: Discussionmentioning

confidence: 99%

Tissue reaction and biodegradation of implanted cross‐linked high amylose starch in rats

Désévaux

Dubreuil

Lenaerts

et al. 2002

J. Biomed. Mater. Res.

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The biocompatibility and degradation characteristics of cross-linked high amylose starch (Contramid were investigated in rats over 4 months. Contramid pellets (3-mm diameter and thickness) obtained by direct compression, were implanted subcutaneously and intramuscularly. On sequential time points, macroscopic observations of implantation sites were performed and tissue samples were removed, fixed, and histologically evaluated. No macroscopic inflammatory reaction was observed with Contramid.. Upon histologic examination, inflammatory reaction produced by Contramid was moderate and restricted to implantation sites. The sequence of inflammatory events with Contramid was similar regardless of implantation site. Degradation of Contramid pellets was characterized by fragmentation with formation of fibrovascular septa and phagocytosis by macrophages. Finally Contramid was mostly absorbed by the end of the 4-month period and substituted by adipocytes. It has been demonstrated that Contramid is a biocompatible and absorbable material.

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Section: Discussionmentioning

confidence: 99%

Tissue reaction and biodegradation of implanted cross‐linked high amylose starch in rats

Désévaux

Dubreuil

Lenaerts

et al. 2002

J. Biomed. Mater. Res.

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“…The solubility values of cassava starch is usually comprised between 25 and 48%, that is, higher than those of other starches (17–28%) . Its plasticity was found to be dependent on particle size, size distribution, particle shape,moisture content, and compaction speed . Because raw starches have limited binding properties, they are usually transformed (chemical, physical, and enzymatic modification) before use .…”

Section: Binders: Classification and Characteristicsmentioning

confidence: 99%

Potential of locally available products for use as binders in producing fecal compost pellets in ghana

Nikiema

Cofie

Asante-Bekoe

et al. 2013

Env Prog and Sustain Energy

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Market studies in Ghana have revealed a potential for composted or cocomposted fecal matter as nutrient source inputs for agricultural production. To increase the marketability of such products, high nutrient value and easier handling/transporting options are among the significant factors which drive demand. Pelletization is seen as a potentially interesting option to address these challenges. To preserve form stability of the pellet products, the addition of a binding material during the pelletization process is crucial. In Ghana, water, beeswax, clay, and cassava starch have been identified as locally available binding materials. A comparative assessment of these materials as a premier binder suitable for pelletization was performed based on predefined criteria. Quantitative criteria considered included the total amounts available, the seasonal variation during the year and cost. Qualitative criteria such as handling and storage conditions, ease of use during pelletization, and the binding ability were also evaluated. Based on this assessment, clay and cassava-based starch were selected as the most promising binding agents. Currently, clay is abundant in Ghana and this may suggest a guarantee for consistent and stable supply over coming years. However, from the perspective of cassava-based starch, this situation depicts limited production of starch and competition on the local markets.

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“…In terms of compactability, Kerry Bioscience batches produced tablets with greater tensile strengths than the DMV-Fonterra and Borculo Domo batches. As the tensile strength increases with increasing bonding capacity of the powder, the presence of increased levels of fine particles could lead to the greater interparticulate contact areas and, hence, higher compacted strengths within the tablets (20).…”

Section: Compressibility and Compactabilitymentioning

confidence: 99%

Investigation into the Degree of Variability in the Solid-State Properties of Common Pharmaceutical Excipients—Anhydrous Lactose

et al. 2010

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Influence of Physical Parameters and Lubricants on the Compaction Properties of Granulated and Non-granulated Cross-linked High Amylose Starch.

Cited by 18 publications

References 30 publications

Tissue reaction and biodegradation of implanted cross‐linked high amylose starch in rats

Tissue reaction and biodegradation of implanted cross‐linked high amylose starch in rats

Potential of locally available products for use as binders in producing fecal compost pellets in ghana

Investigation into the Degree of Variability in the Solid-State Properties of Common Pharmaceutical Excipients—Anhydrous Lactose

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