Influence of physical properties of carrier on the performance of dry powder inhalers

Peng, Tingting; Lin, Sisi; Niu, Boyi; Wang, Xinyi; Huang, Ying; Zhang, Xuejuan; Li, Ge; Pan, Xin; Wu, Chuanbin

doi:10.1016/j.apsb.2016.03.011

Cited by 138 publications

(80 citation statements)

References 81 publications

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“…10 Carriers are used to enhance the powder flow which improves the dosing accuracy of the drugs. 11 This study compares the in-vitro testing of the amount of drug delivery between the twin glass impinger and the next generation impactor using a dry powder inhaler. It also compares the delivery efficiency of four different carriers including mannitol, lactose monohydrate, trehalose and sucrose of the drug into the lungs.…”

Section: Introductionmentioning

confidence: 99%

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

2019

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Section: Introductionmentioning

confidence: 99%

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

2019

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“…19 Although the mechanism through which fine carrier particles improve drug delivery is unclear, the literature suggests that fine carriers with similar geometric sizes to the drug should be used. [19][20][21] The 2:1 ratio of fine to coarse lactose monohydrate carrier particles may be suitable for weak interactions and may decrease the aggregation of sildenafil citrate with α-cyclodextrin complexed particles and lactose monohydrate to better deliver the drug deep into the lung. All three formulations show MMAD values between 3-4 µm, which are suitable for drug deposition in the lung.…”

Section: Discussionmentioning

confidence: 99%

Development of Spray-Dried Sildenafil Citrate -α-cyclodextrin Complexes for Use in Dry Powder Inhalers

Atipairin

Sawatdee

2020

IJPI

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Background: Sildenafil citrate is a drug used in the treatment of pulmonary hypertension. The development of sildenafil citrate complexed with α-cyclodextrin as dry powder inhaler (DPI) should enhance its solubility in the lung. Methods: Sildenafil citrate was dissolved with α-cyclodextrin solution at pH 4.5 to obtain inclusion complexes. The complex solution was spray-dried to make spheroidal powder. The sildenafil DPI formulations were mixed with coarse lactose and fine lactose as carriers and then filled in capsule no. 2. Three different ratios of course to fine lactose were used (1:1 (#1), 2:1 (#2) and 3:1 (#3)) to optimize the performance and aerosol properties. The fine particle fraction (FPF), mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) were used to evaluate the in vitro drug delivery performance in the lung by in vitro. Results: The proportion of sildenafil in formulations #1, #2, #3 was 100.2% ± 0.1%, 100.1% ± 0.2% and 98.9% ± 0.1%, respectively. The aerosol properties of the best formulation (#2) were as follows: an ED of 85.5 ± 0.5%, an FPF of 56.6 ± 2.3%, an MMAD of 3.2 ± 0.6 µm and a GSD of 1.02±0.01. Conclusion: Sildenafil citrate complexed with α-cyclodextrin was successfully developed for a DPI by using coarse and fine lactose monohydrate in a 2:1 ratio.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…Moreover, several active pharmaceutical ingredients are highly potent: drugs used for the treatment of diseases such as asthma are already effective at a low dose. For instance, only 200-400 μg for salbutamol and 6-12 μg for formoterol are required for the drug to be effective [59]. This arises issues concerning powder handling as well as precise metering of doses.…”

Section: Formulations In the Pulmonary Drug Deliverymentioning

confidence: 99%

Formulation and Characterization of Pulmonary Drug Delivery Systems

Magramane

Pápay

Turbucz

et al. 2019

APH

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The inhalation therapy is one of the oldest drug delivery methods known. The significance of inhalation can be understood notably through its remarkable history. The goals of this review are to explore the pulmonary drug delivery, its significant relevance and various advantageous properties, particularly due to the physiology of the lungs. The drug delivery into the lungs can be provided by several inhalation instruments presently accessible on the market such as nebulizers, MDIs, and DPIs. Supplementary devices suchlike spacers for instance are also available in order to optimize the therapy results. The efficiency of these devices depends on several parameters of the formulation used, as well as its deposition in the lungs. Therefore, this review focuses on the meticulous testing performed on both the formulation and the device carrying it in the interest of insuring safety, quality, and efficacy of the final product. Ultimately, the pulmonary drug delivery represents a substantially advantageous alternative route of administration to obtain a systemic effect as well. This review aims to the better understanding of the development of pulmonary dosage forms and its complex process which requires extensive considerations and thorough optimization.

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Influence of physical properties of carrier on the performance of dry powder inhalers

Cited by 138 publications

References 81 publications

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

Comparison between the next generation impactor and the twin glass impinge as model pulmonary drug delivery devices

Development of Spray-Dried Sildenafil Citrate -α-cyclodextrin Complexes for Use in Dry Powder Inhalers

Formulation and Characterization of Pulmonary Drug Delivery Systems

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