Influence of Phytostanol Phosphoryl Ascorbate (FM-VP4) on Insulin Resistance, Hyperglycemia, Plasma Lipid Levels, and Gastrointestinal Absorption of Exogenous Cholesterol in Zucker (fa/fa) Fatty and Lean Rats

Zamfir, Catalina; Pritchard, P H; Pederson, Raymond A.

doi:10.1002/jps.10297

Cited by 14 publications

(15 citation statements)

References 24 publications

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“…It is known that DAPP, as well as traditional plant sterols, inhibit intestinal cholesterol absorption. 1,3,18,19 Therefore, enhanced fecal energy output may be a consequence of increased fecal cholesterol excretion due to the blockage of absorption. However, it is difficult to associate the enhanced energy output to increased cholesterol excretion.…”

Section: Discussionmentioning

confidence: 99%

“…Even supplied in drinking water, DAPP has already been shown to have a beneficial effect on circulating lipid levels and to inhibit intestinal cholesterol absorption in animals. 6,7,19 Clinical studies are required not only to establish the appropriate applications of DAPP for humans but also to determine the effective dosage. Obesity is a major risk factor for morbidity and mortality, and a series of pharmacologic approaches are now available to help manage this problem.…”

Section: Discussionmentioning

confidence: 99%

“…[28][29][30] Orlistat has also been shown to lower cholesterol concentrations in human 31 by inhibiting dietary cholesterol absorption 32 the same way DAPP does in animals. [6][7][8]18,19 It has been reported that 1% (wt/wt) and 2% DAPP in the diet as well as 2 and 4% DAPP in drinking water decrease total and LDL-cholesterol levels in gerbils. 7,8 Recently, Lukic et al 6 reported that in comparison with a diet containing 0.2% cholesterol and no DAPP, a 4-week administration of DAPP at a dose as low as 0.5% reduced total cholesterol concentrations by approximately 75% in cholesterol-fed apolipoprotein E-deficient mice.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to the similarity of both Orlistat and DAPP in altering circulating lipids and cholesterol absorption, there is a possibility that the hypotriglyceridemic action of DAPP may be regulated by similar mechanisms as Orlistat. 18,19 At present, the action of DAPP on the intestinal energy substrate absorption has not been elucidated. However, lower liver weight and plasma triglyceride levels observed in the present study in hamsters fed DAPP may be partially caused by reduced triglyceride absorption and/or lower body weight, consequent to decreased energy absorption in the intestine.…”

Section: Discussionmentioning

confidence: 99%

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Plant stanol ascorbate esters reduce body weight gain through decreased energy absorption in hamsters

et al. 2006

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Objective: The objective of this study was to determine the effects of disodium ascorbyl phytostanyl phosphate (DAPP), a novel hydrophilic phytostanol analogue, on energy homeostasis, including body weight and intestinal energy absorption, and plasma triglyceride concentrations, in hamsters. Methods: Male Golden Syrian hamsters (n ¼ 50) were fed for 5 weeks with experimental diets varying in cholesterol and phytostanol content. Diets included (i) non-cholesterol (semipurified diet without added cholesterol), (ii) cholesterol-control (semipurified diet with 0.25% cholesterol), (iii) stanol (cholesterol-control with 1% free phytostanols), (iv) DAPP 0.7% (cholesterol-control with 0.71% DAPP) or (v) DAPP 1.4% (cholesterol-control with 1.43% DAPP). Fecal samples were collected continuously for 3 days on week 3, and fecal energy output was measured by bomb calorimetry. Results: Hamsters fed 1.4% DAPP gained less (Po0.05) weight than hamsters fed non-cholesterol and stanol diets. Diets had no effect on total food consumption or gross energy intake after 5 weeks, but lower (Po0.05) weekly food consumptions in hamsters fed 1.4% DAPP were observed at weeks 1 and 2 of the experiment in comparison to animals fed the non-cholesterol diet. In comparison to non-cholesterol and cholesterol-control diets, DAPP 1.4% increased (Po0.01) fecal energy output by 47 and 46%, respectively. In hamsters supplemented with 1.4% DAPP, plasma triglyceride concentrations were 45% lower (Po0.05) than in cholesterol-control fed hamsters. Furthermore, plasma triglyceride levels in the DAPP 1.4% group was 49% lower (Po0.01) than in the stanol group, despite the fact that both diets contained equivalent amounts of phytostanols. The lower concentration of DAPP (0.7%) also reduced plasma triglycerides (Po0.05) compared with the stanol diet. Conclusion: Stanol-ascorbate decreases body weight gain in hamsters, likely due to lower energy absorption at the intestinal level. In addition to its previously observed powerful cholesterol-lowering effect, DAPP has a hypotriglyceridemic function in hamsters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Plant stanol ascorbate esters reduce body weight gain through decreased energy absorption in hamsters

et al. 2006

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“…One mechanism that could be involved in this hypocholesterolemic action is the physical competition between phytosterols and cholesterol for incorporation into micelles, which compromises cholesterol absorption [5]. Although most studies have focused on the cholesterol-lowering activity of phytosterols, other biological properties such as antidiabetic agents [6][7][8][9] have also been attributed to these plant compounds. Accordingly, aloe vera-derived phytosterols ameliorated hyperglycemia in treated db/db type 2 diabetic mice [6].…”

Section: Introductionmentioning

confidence: 98%