In this paper, the pile-soil interaction of the pile foundation of an inclined straight alternating group in a liquefiable site under a seismic load was studied through the form changes to the pile cap within the inclined straight alternating group. Based on an analysis of the soil acceleration, hole pressure ratio, horizontal displacement of the pile body, vertical displacement of the pile body, and bending moment of the pile body, the dynamic characteristics of the pile soil at the free site are studied with two layers of liquefiable soil. The results show that the sand layer can amplify seismic waves under a seismic load, and therefore, the soil acceleration under the pile foundation model of the high-rise pile cap group is slightly greater than that of the low-rise pile cap model; then, the pore pressure ratios at the monitoring point in the low-rise pile cap and high-rise pile cap pile foundation models present certain fluctuations. The analysis of the pile displacement and the bending moment shows that the pile foundation from the high-rise pile cap group can resist the seismic load better than that from the low-rise pile cap group. INDEX TERMS Concrete oblique-straight alternating pile group, numerical simulation, inclined straight alternate pile, seismic response, low-and high-rise pile cap, pile-soil interaction.