Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam

Munar, Girlie M.; Munar, Melvin L.; Tsuru, Kanji; Ishikawa, Kunio

doi:10.4012/dmj.2013-031

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…Kitamura et al applied hydroxypropylcellulose coating to porous α-TCP. 32) The coated sample showed controlled bioabsorption corresponding to new bone formation.…”

Section: Bioactive Ceramics For Bone Tissue Re-pairmentioning

confidence: 98%

Organic–Inorganic Composites Designed for Biomedical Applications

Miyazaki

Ishikawa

Shirosaki

et al. 2013

Biological & Pharmaceutical Bulletin

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Several varieties of ceramics, such as Bioglass-type glasses, sintered hydroxyapatite and glass-ceramic A-W, exhibit specific biological affinity, i.e., direct bonding to surrounding bone, when implanted in bony defects. These bone-bonding ceramics are called bioactive ceramics and are utilized as important bone substitutes in the medical field. However, there is a limitation to their clinical applications because of their inappropriate mechanical properties. Natural bone takes a kind of organic-inorganic composite, where apatite nanocrystals are precipitated on collagen fibers. Therefore, problems with the bioactive ceramics can be solved by material design based on the composites. In this paper, current research topics on the development of bioactive organic-inorganic composites inspired by actual bone microstructure have been reviewed in correlation with preparation methods and various properties. Several kinds of inorganic components have been found to exhibit bioactivity in the body environment. Combination of the inorganic components with various organic polymers enables the development of bioactive organic-inorganic composites. In addition, novel biomedical applications of the composites to drug delivery systems, scaffolds for tissue regeneration and injectable biomaterials are available by combining drugs or biological molecules with appropriate control of its microstructure.

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“…Kitamura et al applied hydroxypropylcellulose coating to porous α-TCP. 32) The coated sample showed controlled bioabsorption corresponding to new bone formation.…”

Section: Bioactive Ceramics For Bone Tissue Re-pairmentioning

confidence: 98%

Organic–Inorganic Composites Designed for Biomedical Applications

Miyazaki

Ishikawa

Shirosaki

et al. 2013

Biological & Pharmaceutical Bulletin

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“…In fact, osteogenesis imperfecta, or Lobstein syndrome, is known to be caused by a deficiency in type I collagen [5,6]. Recently, a poly (L) lactic acid glycolic acid (PLGA) copolymer and ε-caprolactone were reported to be effective in CO 3 Ap foam reinforcement [7,8,9,10]. In both cases, the mechanical strength of the foam was improved significantly by coating it with these materials.…”

Section: Introductionmentioning

confidence: 99%

“…In both cases, the mechanical strength of the foam was improved significantly by coating it with these materials. Although both polymers are classified as bioresorbable, the tissue response to them is relatively poor [7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

et al. 2016

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Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.

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“…hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BCP) [1,5]. Currently, porous calcium phosphate scaffolds are prepared using a number of manufacturing techniques, including polymer foam replication, gel-casting, foaming, etc [6][7][8][9][10][11]. Amongst these methods, polymer foam replication could be the best to produce a full 3D interconnected structure and allow the fabrication of a reproducible structure as well as large-scale production.…”

Section: Introductionmentioning

confidence: 99%

Development of a bone substitute material based on alpha-tricalcium phosphate scaffold coated with carbonate apatite/poly-epsilon-caprolactone

Bang¹,

Purbolaksono²,

Long³

et al. 2015

Biomed. Mater.

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Interconnected porous tricalcium phosphate ceramics are considered to be potential bone substitutes. However, insufficient mechanical properties when using tricalcium phosphate powders remain a challenge. To mitigate these issues, we have developed a new approach to produce an interconnected alpha-tricalcium phosphate (α-TCP) scaffold and to perform surface modification on the scaffold with a composite layer, which consists of hybrid carbonate apatite / poly-epsilon-caprolactone (CO3Ap/PCL) with enhanced mechanical properties and biological performance. Different CO3Ap combinations were tested to evaluate the optimal mechanical strength and in vitro cell response of the scaffold. The α-TCP scaffold coated with CO3Ap/PCL maintained a fully interconnected structure with a porosity of 80% to 86% and achieved an improved compressive strength mimicking that of cancellous bone. The addition of CO3Ap coupled with the fully interconnected microstructure of the α-TCP scaffolds coated with CO3Ap/PCL increased cell attachment, accelerated proliferation and resulted in greater alkaline phosphatase (ALP) activity. Hence, our bone substitute exhibited promising potential for applications in cancellous bone-type replacement.

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Influence of PLGA concentrations on structural and mechanical properties of carbonate apatite foam

Cited by 8 publications

References 17 publications

Organic–Inorganic Composites Designed for Biomedical Applications

Organic–Inorganic Composites Designed for Biomedical Applications

Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam

Development of a bone substitute material based on alpha-tricalcium phosphate scaffold coated with carbonate apatite/poly-epsilon-caprolactone

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