Influence of polyethylene glycol and povidone on the polymorphic transformation and solubility of carbamazepine

Nair, R. V.; Gonen, Shmuel; Hoag, Stephen W.

doi:10.1016/s0378-5173(02)00083-2

Cited by 82 publications

(56 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The trained version of Eq. 1 35) : (10) was used to predict the solubility of acetaminophen and ibuprofen in ethanol-water mixtures, in which the MRDs are 26.5% and 42.7%, respectively. The corresponding values for Eq.…”

Section: 4mentioning

confidence: 99%

“…PEGs can be used as a solubilization agent in the formulation of liquid pharmaceutical formulations 8,9) and as dissolution rate enhancers. 10) The often used method to optimize the solvent composition of the mixtures for dissolving a desired amount of a drug in a given volume of the solution is the trial-and-error approach which is time-consuming and expensive and employing cosolvency models could be an appropriate solution. Of the numerous models developed in recent years, the Jouyban-Acree model is perhaps one of the most versatile models.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Solubility of Acetaminophen and Ibuprofen in Binary and Ternary Mixtures of Polyethylene Glycol 600, Ethanol and Water

Soltanpour

Jouyban

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Experimental solubilities of acetaminophen and ibuprofen in polyethylene glycol 600-water, ethanol-polyethylene glycol 600, and polyethylene glycol 600-water-ethanol mixtures at 25°C are reported. The solubilities of drugs in the presence of ethanol and polyethylene glycol 600 were increased. The Jouyban-Acree model was used to fit the solubility data of each drug in the binary mixtures in which the overall mean relative deviations (OMRDs) for acetaminophen and ibuprofen were 2.9% and 4.3%, respectively. The OMRDs for ternary solvent mixtures for acetaminophen and ibuprofen were 16.8% and 22.4%, respectively. Generally, the errors associated with ibuprofen are larger than that of acetaminophen in both binary and ternary solvent mixtures. The solubilities were predicted using previously trained versions of the Jouyban-Acree and log-linear models with the OMRDs of 38.8% and 52.1%, respectively. Density of the mixed solvents in the absence of the solute was measured and used to train the model and then the density of the saturated solutions was predicted using the trained model and the density of the saturated solutions in mono-solvent systems with the OMRD of 3.2%.

show abstract

Section: 4mentioning

confidence: 99%

mentioning

confidence: 99%

Solubility of Acetaminophen and Ibuprofen in Binary and Ternary Mixtures of Polyethylene Glycol 600, Ethanol and Water

Soltanpour

Jouyban

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Carbamazepine (CBZ) is practically insoluble in water and facing challenges of dissolution-limited bioavailability [3], [9]- [13]. CBZ is a drug that used as anticonvulsant for treatment of epilepsy and trigeminal neuralgia [14].…”

Section: Introductionmentioning

confidence: 99%

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Rahman¹,

Rahim²,

Chou³

et al. 2017

IJCEA

View full text Add to dashboard Cite

Abstract-Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal.

show abstract

“…Solubility studies [16][17][18] These studies were performed by taking in which the pure drug Furosemide and accurate weighed solid dispersion formulation which was theoretically equivalent to 80 mg of Furosemide added to a volume of distilled water at room temperature and gradually increases the volume of distilled water until it was not completely dissolves. The drug amount per part of volume was determined by using this technique.…”

Section: Evaluation Of Solid Dispersionmentioning

confidence: 99%

Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers

Soni¹,

Ansari²,

Thakre³

et al. 2017

IJRDPL

View full text Add to dashboard Cite

Abstract:Objective: The objective of the present investigation was to improve solubility and dissolution characteristics of Furosemide, which might offer improved bioavailability. The bioavailability of the drug when taken orally is limited by the relatively low solubility. Furosemide is a loop diuretic (a 'water pill') used to treat congestive heart failure, oedema and sometimes hypertension. Method: The solid dispersion of Furosemide was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, PEG6000). The solid dispersion was prepared by solvent evaporation method. The prepared solid dispersion was evaluated for various parameters like uniformity of drug content, in-vitro drug release and short term stability studies. Results:The prepared dispersion showed marked increase in the dissolution rate of Furosemide than that of pure drug and the in vitro release studies revealed that there was an improvement in the dissolution characteristics of drug when prepared as solid dispersions. Solid dispersion with PEG 6000 and PVPK30 gave better rate and extent of dissolution. Conclusion: It can be concluded that the solid dispersions prepared with PEG6000 and PVP K30 and among all the formulations, F6 has highest solubility and in vitro dissolution rate.

show abstract

Influence of polyethylene glycol and povidone on the polymorphic transformation and solubility of carbamazepine

Cited by 82 publications

References 17 publications

Solubility of Acetaminophen and Ibuprofen in Binary and Ternary Mixtures of Polyethylene Glycol 600, Ethanol and Water

Solubility of Acetaminophen and Ibuprofen in Binary and Ternary Mixtures of Polyethylene Glycol 600, Ethanol and Water

Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method

Development and in-vitro evaluation of Furosemide Solid Dispersion using different Water Soluble Carriers

Contact Info

Product

Resources

About