Influence of polymer coating on release of l-dopa from core-shell Fe@Au nanoparticle systems

Bandyopadhyay, Sulalit; Alvi, Muhammad Awais Ashfaq; Sharma, Anuvansh; Zhu, Kaizheng; Kjøniksen, Anna–Lena; Nyström, Bo; Glomm, Wilhelm R.

doi:10.1007/s00396-017-4015-y

Cited by 3 publications

(2 citation statements)

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“…In particular, biological fluid samples and dairy product samples contain various biomacromolecules. 13,14 Sample pretreatment is an effective method to reduce the influence of the adsorption of macromolecules, which were verified and widely adopted. Nevertheless, the process of this method is time-consuming and complex, which impedes the extension of this method in the field of POCT.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Surface-enhanced Raman scattering (SERS) is one of the promising spectral analysis techniques for widespread application in the field of point-of-care testing (POCT) based on identification of the characteristic fingerprint information of analyte molecules with the nondestructive detection property. − The analyte molecules adsorb on the surface or within 10 nm of metal nanostructures, due to the localized surface plasmon resonance (LSPR) of the metal nanostructures; the Raman intensity of the analyte is enhanced dramatically. − However, many macromolecules exist in most actual samples and irreversibly adsorb on the surface of metal nanostructures during SERS detection, which affects the expression of small molecules in the localization of the electromagnetic field of the metal nanostructures. In particular, biological fluid samples and dairy product samples contain various biomacromolecules. , Sample pretreatment is an effective method to reduce the influence of the adsorption of macromolecules, which were verified and widely adopted. Nevertheless, the process of this method is time-consuming and complex, which impedes the extension of this method in the field of POCT.…”

Section: Introductionmentioning

confidence: 99%

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Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix

et al. 2021

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Surface-enhanced Raman scattering (SERS) is a supersensitive analysis technology based on the target molecular fingerprint information. The enhancement of local electromagnetic field of the SERS substrate would increase the target molecules' Raman intensity which adsorb on the surface of nanoparticles. However, the existing adhesive macromolecules in the complex mixed sample would interfere with the adsorption of small target molecules, and it weakens the Raman intensity of target molecules. Microgels are one of the potential materials to suppress the interference of adhesive macromolecules and to avoid the complex pretreatments. However, most of the current microgel synthesis methods involve complex operations with precise instrumentation or the interference of oil and organic reagents. In this work, a simple and oil-free method was proposed to synthesize the gold nanobipyramid (Au NBP) @Ag@hyaluronic acid microgel via the condensation reaction of carboxyl and amino groups. As a proof-of-concept demonstration for small-molecule detection, the rhodamine 6G (R6G) molecules were allowed to enter inside the microgel through the meshes and adsorb on the surface of Au NBP@Ag nanoparticles within 30 min, while the macromolecule (bovine serum albumin in this case) was retained outside the microgel in the meantime. In addition, under the combined action of lightning rod effect of Au NBP and surface plasmon resonance effect of silver render the microgels with high SERS activity. The synthetic Au NBP@Ag@hyaluronic acid microgels were applied to detect 6-thioguanine in the human serum without any pretreatment process, and it showed a high signal enhancement and stable SERS signal, which can satisfy the requirement of clinical diagnosis. These results show that the proposed microgels have potential applications in the field of point-of-care testing.

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Section: ■ Introductionmentioning

confidence: 99%