Influence of powder‐to‐water ratio on radiopacity, setting time, <scp>pH</scp>, calcium ion release and a micro‐<scp>CT</scp> volumetric solubility of white mineral trioxide aggregate

Cavenago, Bruno Cavalini; Pereira, Thais Cristina; Duarte, Marco Antônio Húngaro; Ordinola‐Zapata, Ronald; Marciano, Marina Angélica; Bramante, Clóvis Monteiro; Bernardineli, Norberti

doi:10.1111/iej.12120

Cited by 117 publications

(159 citation statements)

References 21 publications

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“…Atomic absorption spectrophotometry has been used successfully in earlier studies for analyzing calcium ions, 15,16 whereas the setting time evaluation using Gillmore needles is a standard test method that has been used previously to evaluate the setting time of MTA-based materials. 15,17 In the present study, W-MTA showed the highest pH values. It is well-established that MTA promotes an alkaline pH in a physiological solution.…”

Section: Discussionsupporting

confidence: 52%

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

et al. 2015

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The addition of chlorhexidine (CHX) to a resinous experimental Mineral Trioxide Aggregate (E-MTA) based root-end filling material is an alternative to boost its antimicrobial activity. However, the influence of chlorhexidine on the properties of this material is unclear. The aim of this study was to evaluate the influence of 2% chlorhexidine on the pH, calcium ion release and setting time of a Bisphenol A Ethoxylate Dimethacrylate/Mineral Trioxide Aggregate (Bis-EMA/MTA) based dual-cure experimental root-end filling material (E-MTA), in comparison with E-MTA without the addition of CHX and with conventional white MTA (W-MTA). The materials were placed in polyethylene tubes, and immersed in deionized water to determine pH (digital pH meter) and calcium ion release (atomic absorption spectrometry technique). The setting time of each material was analyzed using Gilmore needles. The data were statistically analyzed at a significance level of 5%. E-MTA + CHX showed an alkaline pH in the 3 h period of evaluation, the alkalinity of which decreased but remained as such for 15 days. The pH of E-MTA + CHX was higher than the other two materials after 7 days, and lower after 30 days (p < 0.05). All of the materials were found to release calcium ions throughout the 30 days of the study. The addition of CHX increased the calcium ion release of E-MTA to levels statistically similar to W-MTA. E-MTA showed shorter initial and final setting time, compared with W-MTA (p < 0.05). The addition of 2% CHX to MTA prevented setting of the material. The addition of CHX to E-MTA increased its pH and calcium ion release. However, it also prevented setting of the material.

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Section: Discussionsupporting

confidence: 52%

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

et al. 2015

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“…MTA is a bioactive dental material and a calciumreleasing cement [10][11][12] . Although the release of calcium ions from MTA may cause an interaction between MTA and the surrounding tissues, the pathway by which CaSR contributes directly to the regulation of osteoblast differentiation via calcium ion released from MTA remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…In turn, the calcium hydroxide dissociates into calcium and hydroxide ions, which disperse into the surrounding environment, resulting in MTA bioactivity 7) . Some in vitro studies have indicated that calcium ions are released continuously from MTA [10][11][12] . Takita et al reported that the release of ions from MTA provides the optimum amount of calcium for the proliferation and migration of dental pulp cells 4,13) .…”

Section: Introductionmentioning

confidence: 99%

Involvement of the calcium-sensing receptor in mineral trioxide aggregate-induced osteogenic gene expression in murine MC3T3-E1 cells

Yasukawa

Hayashi

Tanabe

et al. 2017

Dental Materials Journal

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Mineral trioxide aggregate (MTA) has excellent biocompatibility as well as bioactivity, including an ability to induce osteoblast differentiation. We examined the effects of the calcium-sensing receptor (CaSR) on osteogenic gene expression induced by MTA. MC3T3-E1 cells were cultured with or without (control) MTA. The expression levels of Runx2, type I collagen, and CaSR genes were analyzed by real-time polymerase chain reaction and their products were measured using enzyme-linked immunosorbent assays. The levels were increased significantly in cells exposed to MTA compared with control. Next, MC3T3-E1 cells were cultured with MTA and EGTA (a calcium chelator), because calcium ions were released continuously from MTA into the culture. Expression levels were decreased to control levels by MTA plus EGTA. NPS2143 (a CaSR antagonist) also reduced MTA-induced gene expression. These results suggest that MTA induced osteogenic gene expressions of Runx2 and type I collagen via CaSR in MC3T3-E1 cells.

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“…A proporção pó/líquido pode alterar o pH e a liberação de íons cálcio do MTA (CAVENAGO, et al, 2013). A adição de maiores proporções de líquido na mistura resulta em aumento do pH e da liberação de cálcio.…”

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“…A adição de maiores proporções de líquido na mistura resulta em aumento do pH e da liberação de cálcio. Este fenômeno pode estar relacionado com a maior solubilização do cimento (CAVENAGO, et al, 2013 …”

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Propriedades físico-químicas e biológicas de cimento experimental à base de Portland associado a diferentes radiopacificadores

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Influence of powder‐to‐water ratio on radiopacity, setting time, pH, calcium ion release and a micro‐CT volumetric solubility of white mineral trioxide aggregate

Abstract: The ratio of powder/water significantly interfered with the physical and chemical properties of white MTA Angelus.

Cited by 117 publications

References 21 publications

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

Influence of 2% chlorhexidine on pH, calcium release and setting time of a resinous MTA-based root-end filling material

Involvement of the calcium-sensing receptor in mineral trioxide aggregate-induced osteogenic gene expression in murine MC3T3-E1 cells

Propriedades físico-químicas e biológicas de cimento experimental à base de Portland associado a diferentes radiopacificadores

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