Influence of Prediabetes on Coronary Atherosclerotic Plaque Burden Assessed by Coronary Computed Tomography Angiography (CCTA).

Manubolu, Venkat Sanjay; Verghese, Dhiran; Alalawi, Luay; Kinninger, April; Calicchio, Francesca; Ahmad, Khadije; Ghanem, Ahmed; Rezvanizadeh, Vahid; Javier, Denise Alison; Vacuna, Will; Golub, Ilana; Termeie, Orly G.; Schroeder, Lucia P.; Kristo, Stephanie; Roy, Sion K.

doi:10.1016/j.ahj.2021.10.059

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“…CAC is a well-established indicator of atherosclerosis, incident coronary heart disease and all-cause mortality in patients with and without diabetes. 23,24 Although not all studies have reported a significant association between prediabetes and CAC scores, 25 most studies have shown an independent association between them, [26][27][28] consistent with our study results. However, none of these studies have focused on the differences in CAC scores between prediabetes defined by HbA1c and FBG levels.…”

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confidence: 91%

Prediabetes diagnosis is associated with the progression of coronary artery calcification: The Kangbuk Samsung Health Study

Choi

Chang

Cho

et al. 2022

Diabetes Obesity Metabolism

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Aim: To investigate the associations between prediabetes defined by different diagnostic criteria and coronary artery calcification (CAC) and its progression over time. Materials and Methods:This cross-sectional study included 146 436 Korean adults without diabetes who underwent CAC estimation computed tomography (CT) during health examinations from 2011 to 2019. We used multinomial logistic regression models. The longitudinal study comprised 41 100 participants with at least one follow-up cardiac CT and annual CAC progression rates and ratios were estimated.Prediabetes was categorized into three groups: isolated glucose prediabetes (fasting blood glucose [FBG] 100-125 mg/dl, HbA1c < 5.7%), isolated HbA1c prediabetes (FBG < 100 mg/dl, HbA1c 5.7%-6.4%) and prediabetes meeting both FBG and HbA1c criteria (FBG 100-125 mg/dl, HbA1c 5.7%-6.4%).Results: After adjusting for covariates, the prevalence ratios (95% CI) for CAC scores of more than 100 comparing isolated glucose prediabetes, isolated HbA1c prediabetes and prediabetes fulfilling both criteria with those of normoglycaemia were 1.12 (0.99-1.26), 1.24 (1.11-1.39) and 1.31 (1.18-1.45), respectively. The multivariableadjusted ratio (CIs) of annual CAC progression rates comparing the corresponding groups with the normoglycaemia group were 1.

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