A patient is described who produced antibodies during a period of bone
marrow failure produced by prolonged administration of busulfan for chronic
myelogenous leukemia. The patient produced antibodies to transfused blood constituents
including serum IgA, leukocytes and platelets after minimal stimulus. This
case illustrates that under certain conditions the so-called immunosuppressive
agents can cause a paradoxical heightening of antibody response.