Influence of Pregnancy on Dipeptidyl Peptidase IV Activity (CD 26 Leukocyte Differentiation Antigen) of Circulating Lymphocytes

Abstract

Sununary: Dipeptidyl peptidase IV (CD 26 leukocyte differentiation antigen) is an enzymic surface marker of a human T lymphocyte subpopulation which has been shown to be associated with their capacity to produce large amounts of interleukin 2 and proliferate strongly in response to mitogenic Stimulation. The peptidase activity on the surface of purified human peripheral mononuclear cells was determined spectrophotometrically with the Substrate glycyl-L-proline-4-nitranilide. The peripheral mononuclear cells of pregnant women exhibited depressed mean dipeptidyl peptidase IV activity when compared with the activity of peripheral mononuclear cells from non-pregnant or male individuals. The gestational age (7 to 20 weeks) of the pregnant collective had no effects on peptidase levels. Women taking oral contraceptives had a slightly lower mean activity than the non-pregnant group not using contraceptives. Thus, reduced dipeptidyl peptidase IV activity of peripheral mononuclear cells might reflect impairement of cellülar immunity during pregnancy.

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

“…CD26 expression and activity may be reduced in T-cell subsets from patients with active HIV [108,109], but increased in HIV-infected subjects with immune reconstitution [110]. In contrast, serum DPP-IV activity is decreased during pregnancy [111], in subjects with active Crohn's disease [112], major depressive illness [113,114], eating disorders [115], active systemic lupus erythematosis [116] or rheumatoid arthritis [117]. Similarly, serum DPP-IV activity is decreased in subjects with active Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis, with levels increasing in patients with disease remission [118].…”

Inhibition of dipeptidyl peptidase IV by fluoroolefin-containingN-peptidyl-O-hydroxylamine peptidomimetics

“…Of the many functions that have been postulated (9)(10)(11)(12)(13)(14), the most intriguing is the role of DPP IV in T-cell activation and in the regulation of T-cell proliferation (13,(15)(16)(17)(18). Recognized as a cell surface activation marker of lymphocytes (19), the failure to observe CD26 implies a reduced immune response (20). The presence of DPP IV is associated with the capacity of cells to produce interleukin 2 and to proliferate strongly in response to mitogen stimulation (20,21).…”

“…Recognized as a cell surface activation marker of lymphocytes (19), the failure to observe CD26 implies a reduced immune response (20). The presence of DPP IV is associated with the capacity of cells to produce interleukin 2 and to proliferate strongly in response to mitogen stimulation (20,21). Importantly, binding of mAbs to CD26 suppresses interleukin 2 production (21).…”

A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence

“…Specific inhibition of DPP IV activity suppressed alkylamine-and adjuvant-induced arthritis [70,71], pointing to a role for DPP IV enzymic activity in the pathogenesis of experimentally induced arthritis. Plas- [79] in serum on lymphocytes Systemic lupus erythematosus [67] in serum in all patients No data available in lymphocytes of patients with active disease Rheumatoid arthritis [69] in synovial fluid No data available Pregnancy [80] in serum No data available AIDS [78] Normal no. of DPP IV-positive lymphocytes Major depression [81] in serum No data available Schizophrenia [82] in serum No data available Fibromyalgia [83] Normal No data available Anorexia nervosa [84] in serum no.…”