Influence of preoperative administration of ω-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer

Nakamura, Kazuo; Kariyazono, Hiroko; Komokata, Teruo; Hamada, Nobuo; Sakata, Ryuzo; Yamada, Katsushi

doi:10.1016/j.nut.2005.03.001

Cited by 70 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A particular area of emphasis has been placed on immunomodulatory effects of n-3 PUFAs, owing to their ability to reduce infection and inflammation (102,113,114). Administration of n-3 PUFAs either before or after major abdominal surgery for cancer was shown to reduce inflammatory cytokines (113,115) and improve liver and pancreas function (116). Patients receiving parenteral immunonutrition with a nutritional supplement containing glutamine or n-3 PUFAs had reduced incidence of infectious complications and improved immune function compared to patients who received a nutritional supplement without glutamine or n-3 PUFAs (102).…”

Section: Nutritional Support Of Cancer Patients With N-3 Pufa Supplemmentioning

confidence: 99%

Multi-targeted therapy of cancer by omega-3 fatty acids

2008

View full text Add to dashboard Cite

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are essential fatty acids necessary for human health. Currently, the Western diet contains a disproportionally high amount of n-6 PUFAs and low amount of n-3 PUFAs, and the resulting high n-6/n-3 ratio is thought to contribute to cardiovascular disease, inflammation, and cancer. Studies in human populations have linked high consumption of fish or fish oil to reduced risk of colon, prostate and breast cancer, although other studies failed to find a significant association. Nonetheless, the available epidemiological evidence, combined with the demonstrated effects of n-3 PUFAs on cancer in animal and cell culture models, has motivated the development of clinical interventions using n-3 PUFAs in the prevention and treatment of cancer, as well as for nutritional support of cancer patients to reduce weight loss and modulate the immune system. In this review, we discuss the rationale for using long-chain n-3 PUFAs in cancer prevention and treatment and the challenges that such approaches pose in the design of clinical trials.

show abstract

Section: Nutritional Support Of Cancer Patients With N-3 Pufa Supplemmentioning

confidence: 99%

Multi-targeted therapy of cancer by omega-3 fatty acids

2008

View full text Add to dashboard Cite

show abstract

“…Clinical trials using immunomodulatory formulas containing ω3 (3.3g/day), arginine (1.2g/day) and nucleotides (1.2g/ day) for seven consecutive days before and after surgery in cancer patients has showed that the immune response seen in patients receiving supplemented diets occurred later (after the 2 nd postoperative day) [2][3]5 . These findings could can explain the different results obtained in the present study.…”

Section: Ind Vs Pos) (Figure 11mentioning

confidence: 99%

“…Perioperative supplementation with immunomodulatory diets is safe and effective in reducing postoperative infections, length of hospital stay and reduce the need for antibiotics, increasing cellular and humoral immunity compared to standard nutrition [2][3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammatory mediators, oxidative stress and lipid profile in patients undergoing radical prostatectomy

Tavares

Cavalcante

Campelo³

et al. 2014

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma. METHODS:Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2 nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27). RESULTS:There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION:Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect.

show abstract

“…Evidence for this benefit resides in their beneficial effect on known biomarkers of immune capacity and function, such as HLA-DR epitopes on monocytes and serum levels of interleukin-6 in high-risk surgical patients. 66,95 Healthy volunteer studies have also been performed that have demonstrated the beneficial effect of immune-boosting supplementation on experimental models of surgical wound healing and immune function. 7,46 The most compelling evidence for their routine use in surgical patients comes from prospective, randomized, double-blind trials in which preoperative supplementation with arginine, omega-3 fatty acids, and dietary nucleotides resulted in a significantly reduced incidence of postoperative infection.…”

Section: Preoperative Factorsmentioning

confidence: 99%

Infection following operations on the central nervous system: deconstructing the myth of the sterile field

Walcott

Redjal²,

Coumans³

2012

FOC

View full text Add to dashboard Cite

Neurosurgical patients are at a high risk for infectious sequelae following operations. For neurosurgery in particular, the risk of surgical site infection has a unique implication given the proximity of the CSF and the CNS. Patient factors contribute to some degree; for example, cancer and trauma are often associated with impaired nutritional status, known risk factors for infection. Additionally, care-based factors for infection must also be considered, such as the length of surgery, the administration of steroids, and tissue devascularization (such as a craniotomy bone flap). When postoperative infection does occur, attention is commonly focused on potential lapses in surgical “sterility.” Evidence suggests that the surgical field is not free of microorganisms. The authors propose a paradigm shift in the nomenclature of the surgical field from “sterile” to “clean.” Continued efforts aimed at optimizing immune capacity and host defenses to combat potential infection are warranted.

show abstract

Influence of preoperative administration of ω-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer

Cited by 70 publications

References 32 publications

Multi-targeted therapy of cancer by omega-3 fatty acids

Multi-targeted therapy of cancer by omega-3 fatty acids

Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammatory mediators, oxidative stress and lipid profile in patients undergoing radical prostatectomy

Infection following operations on the central nervous system: deconstructing the myth of the sterile field

Contact Info

Product

Resources

About