Influence of preoperative hydronephrosis on the outcome of urothelial carcinoma of the upper urinary tract after nephroureterectomy: the results from a multi-institutional French cohort

Abstract

Preoperative hydronephrosis was not associated with survival. However, among tumours presenting with hydronephrosis, pelvicalyceal tumours appear to have a worse prognosis than ureteral tumours.

Degree of hydronephrosis predicts adverse pathological features and worse oncologic outcomes in patients with high-grade urothelial carcinoma of the upper urinary tract

“…Prior studies have evaluated HN in cohorts composed of both HG and LG tumors. Several studies individually identified that HN was associated with worse oncologic outcomes (metastasis-free survival, CSS, and overall survival), whereas other studies identified no such associations (Table 5) [8,[11][12][13]15]. Furthermore, the relationship between HN and muscle-invasive disease also varied in several studies [9,10,14].…”

“…Presence of HN in UTUC has also been suggested to be associated with advanced pathological stage on final specimen and has been linked to development of cancer metastasis and survival [8][9][10][11][12]. However, confounding studies have identified the contrary [13][14][15]. All prior HN studies evaluated patients with LG and high-grade (HG) UTUCs as 1 cohort.…”

Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy

“…And it is noteworthy that preoperative hydronephrosis, a potential prognostic predictor discussed in some studies [23][24][25][26], was also found to be an independent predictor of survival. Additionally, we also investigated the association between preoperative pyuria and bladder recurrence following RNU (Supplementary Table S1).…”

Predictive role of preoperative hydronephrosis on poor pathological outcomes and prognosis in upper tract urothelial carcinoma patients: Experience from a nationwide high-volume center in China

“…There have been a number of studies focused on the association between the presence of HN and clinicopathological characteristics and prognosis (17,(22)(23)(24)(25)27). The majority of these studies have reported a predictive role of HN in poor pathological outcomes, however, there has been no consensus on the association between HN and poor prognosis.…”

“…Ito et al (22) reported that 67 patients (73.6%) exhibited HN in a retrospective study of 91 cases, and validated the correlation between HN and poor pathological outcomes, whilst a higher HN grade was not associated with disease-specific or metastasis-free survival. Bozzini et al (27) conducted a relatively large-scale study with 401 patients, however, HN was present in only 18.4% of patients and the median follow-up period was 26 months. Furthermore, whilst studies by Messer et al (23) and Brien et al (24) demonstrated that HN was associated with muscle-invasive and non-organ confined disease, these studies were lacking in follow-up data.…”