Influence of prostaglandin E2 infusion on gastrointestinal electrical activity in the conscious piglet

Saedeleer, V. De; Wechsung, E.; Houvenaghel, A.

doi:10.1016/0952-3278(91)90174-4

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…The LPS-induced decrease in the frequency of the antral ECA as well as the increase in the duration of the inhibitory phase and the decrease in the integrated activity in the antrum are also observed during and following intravenous infusion of PGE 2 at 1/zg kg -1 min -1 for 2 h in the piglet (De Saedeleer et al, 1991b). Likewise, the increase in the duodenal phase I activity and also the decrease in the integrated total and phase II activities in this small-intestinal segment were observed during infusion of PGE 2.…”

Section: Discussionmentioning

confidence: 81%

“…Fever is mediated by endogenous substances such as interleukin-1 or endogenous pyrogen, which stimulate the thermoregulatory centres in the hypothalamus by inducing local prostaglandin E 2 (PGE2) synthesis (Lohuis et al, 1988). We recently observed a pronounced febrile response during IV infusion of PGE 2 at 1/~g kg -1 min -1 for 2 h in conscious piglets (De Saedeleer et aL, 1991b).…”

Section: Discussionmentioning

confidence: 99%

“…The influence of IV infusion of PGE,, 0.1 and 1 /zg kg -1 min -1, was also evaluated (De Saedeleer et aL, 1991b). T~ae aim of the present study was to examine the possible involvement of cyclooxygenase metabolites in these endotoxin-induced phenomena.…”

Section: Introductionmentioning

confidence: 99%

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Influence of indomethacin on endotoxin-induced changes in gastrointestinal myoelectrical activity and some haematological and clinical parameters in the conscious piglet

Saedeleer¹,

Wechsung²,

Houvenaghel³

1992

Vet Res Commun

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The effect of indomethacin, administered intravenously at 5 mg/kg, on the changes in gastrointestinal myoelectrical activity, rectal body temperature, clinical appearance and some haematological parameters induced by intravenous bolus injection of endotoxin, at 10 micrograms/kg, was examined in conscious piglets with electrodes implanted in the antrum pylori, duodenum, jejunum and ileum. Indomethacin inhibited the endotoxin-induced febrile response and the accompanying clinical signs. However, it was without influence on the induced leukopenia and shift to the left. Indomethacin both delayed the onset of and shortened the endotoxin-induced increase in the duration of the antral inhibitory phase and the duodenal phase I activity. It therefore appears that prostanoids are probably not the main factors involved in the endotoxin-induced haematological and gastrointestinal myoelectrical activity changes in the piglet.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%