Influence of protein free aqueous extract of parathyroid powder on serum vitamin A level in rats

Abstract

Administration of the protein-free extract of bovine parathyroid powder to rats resulted in a significant increase of the serum vitamin A level.

Synthesis of γ-Glutamyltaurine by γ-Glutamyltranspeptidase ofPenicillium roqueforti

“…One of these bioactive y-glutamyl peptides, y-glutamyltaurine (y-GluTau), is found at very low concentrations in tissues other than nerve tissues,4) although it was first isolated from the parathyroid gland. 5 ,6) It has been proved that y~GluTau has vitamin A-and taurine-like activities,7) and that it enhances the influence of vitamin A, 8) antagonizes the effects of cortisone, thyroxine and prednisolone,9) increases renin activity in plasma,10) and enhances the macrophage reaction in rat thymus tissue cultures. 1t ) Moreover, it is known that the peptide has an influence on metamorphosis and a protective effect against X-rays.…”

Synthesis of Γ‐l‐glutamyl‐taurine*

“…the protein free aqueous extract of bovine parathyroid powder. This substance proved to be responsible for the effects of the extract on serum vitamin A level in rats (Feuer et al, 1977) and on the survival of rats after irradiation with 850 R or 1000 R (Feuer & Ormai, 1978). In this paper three different synthetic procedures for the preparation of this compound are described.…”