Influence of punch geometry (head-flat diameter) and tooling type (‘B’ or ‘D’) on the physical–mechanical properties of formulation tablets

Shah, Harsh; Dugar, Rohit P.; Li, HongHao; Dave, Vivek S; Dave, Rutesh H.

doi:10.1080/03639045.2018.1525395

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…Tablets were compressed at 50 mg core weight in 8 station Tablet press (Remik) using 5 mm round, standard concave, D type tooling 31 .…”

Section: Fig 1: Steps Involved In Fluid Bed Granulation 42mentioning

confidence: 99%

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2022

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The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste masking was achieved using a pH-independent polymeric dispersion of Surelease E-7-19040 in combination with Opadry YS-1-19025-A in different ratios. In-vivo taste evaluation was done to see if the tablets produced utilizing the direct compression approach were successfully disguised. Results: The present study investigated uncoated and coated drug substances and prepared tablets of coated LCDH for flow as well as compression behaviour, Fourier Transform Infrared absorption spectra, Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy and in-vitro dissolution and disintegration properties. Conclusion: Using a combination of two polymeric dispersions "Sure lease E-1-19040" and "Opadry" coating for the delivery of LCDH, it was shown that a taste-masking evaluation could be performed to identify effective polymer-carriers for the LCDH. INTRODUCTION:Taste is one of the important quality attributes that govern the palatability of the formulation and, in turn acceptability by the patient. The bitter taste is one of the foremost challenges that formulators encounter while working with bitter-taste drug molecules.

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“…Tablets were compressed at 50 mg core weight in 8 station Tablet press (Remik) using 5 mm round, standard concave, D type tooling 31 .…”

Section: Fig 1: Steps Involved In Fluid Bed Granulation 42mentioning

confidence: 99%

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2022

IJPSR

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“…For example, if the API deforms elastically under compression pressure, the filler that will be added to this API should deform plastically under working pressure to avoid common tableting problems such as tablet sticking, capping, etc. On the other hand, the manufacturing factors contributing to compressibility and compactability of powders involve: (i) Compression force 8 and (ii) Compression speed 9 . Both these factors are alterable and can be changed to achieve the desired quality of tablets.…”

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confidence: 99%

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2021

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The present work evaluates the impact of alterable manufacturing and formulation factors on the physicomechanical properties of Acetaminophen (APAP); a poorly compressible Active Pharmaceutical Ingredient (API). By varying the amount of APAP and particle size of Microcrystalline Cellulose (MCC), six different formulations were prepared. These formulations were compressed into tablets at different compression pressures and speeds. The porosity of the tablets was evaluated through "outof-die" Heckel analysis. Furthermore, the qualitative and quantitative relationships of (i) Percentage of APAP, (ii) Compression pressures, (iii) Compression speeds, and (iv) Particle size of MCC with tablet porosity were evaluated by principle component analysis (PCA) and principle component regression (PCR). Heckel analysis revealed that increasing the ratio of APAP to MCC in the formulation adds its compressibility when the MCC particle size is similar to that of APAP. While, using large MCC particle size increases the compressibility due to fragmentation of particles, using MCC of small particle size increases the compressibility to a higher extend. The PCA indicated that the percentage of APAP, compression pressure and particle size of MCC are all correlated negatively to tablet porosity. Furthermore, the PCR quantified these correlations to show that tablet porosity was predominantly dependent on compression pressure followed by MCC particle size, APAP percentage, and compression speed in descending order. This work provides an insight into the collective impact of manufacturing and formulation factors on the mechanical properties of tablets, which can help developing an optimized multivariate function to ensure tablet quality of poorly compressible APIs.

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