Influence of pyrethroids and piperonyl butoxide on histamine release from isolated rat mast cells

Grosman, Nina

doi:10.1007/s00011-007-7111-5

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Due to their many advantages, it is very important to research the biological effects of pyrethroid insecticides, which are included the Karate Zeon. Previous studies have reported their toxicity on living organisms (Grossman 2007, Surralles et al 1995.…”

Section: Discussionmentioning

confidence: 99%

Karate Zeon Pestisitinin Mutajenik Aktivitesinin Ames Testi ile Değerlendirilmesi

Özkara

2022

Afyon Kocatepe University Journal of Sciences and Engineering

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Pesticides widely used in the agricultural market led to an increase in the quality and yield of crops. However, pesticides are a major concern in the environment as they also harm non-target creatures, because of pesticide resistance, and mutagenic and carcinogenic effects. In this study, we aimed to research the potential mutagenicity of Karate Zeon which is a synthetic pyrethroid insecticide. Salmonella typhimurium mutagenicity assay (Ames test) was used to evaluate the mutagenicity of Karate Zeon insecticide in the absence and presence of the S9 fraction on two strains (TA98 and TA100). In this study, doses of 250, 25, 2.5, 0.25, 0.025 μg/plate of Karate Zeon were used. Karate Zeon pesticide showed mutagenic activity at 250 μg/plate concentration on both TA98 and TA100 with and without metabolic activation.

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Section: Discussionmentioning

confidence: 99%

Karate Zeon Pestisitinin Mutajenik Aktivitesinin Ames Testi ile Değerlendirilmesi

Özkara

2022

Afyon Kocatepe University Journal of Sciences and Engineering

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“…Another pyrethroid, metofluthrin, is particularly vapor-active against insects and mosquitoes for both indoor and outdoor use [ 57 , 58 ]. Pyrethroids are neurotoxic, possibly by disturbing the membrane function of neuronal cells [ 59 ]. The possible genotoxicity of transfluthrin and metofluthrin was detected by SMART, with transfluthrin (up to 0.103 mg/mL) and metofluthrin (up to 60 μg/mL) as a mutagen and recombinogen, respectively.…”

Section: Applications Of Smart For Genotoxicity Assessment Of Environmental Pollutantsmentioning

confidence: 99%

Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing—A Review

Pitchakarn

Inthachat

Karinchai

et al. 2021

IJMS

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Genomic instability, one of cancer’s hallmarks, is induced by genotoxins from endogenous and exogenous sources, including reactive oxygen species (ROS), diet, and environmental pollutants. A sensitive in vivo genotoxicity test is required for the identification of human hazards to reduce the potential health risk. The somatic mutation and recombination test (SMART) or wing spot test is a genotoxicity assay involving Drosophila melanogaster (fruit fly) as a classical, alternative human model. This review describes the principle of the SMART assay in conjunction with its advantages and disadvantages and discusses applications of the assay covering all segments of health-related industries, including food, dietary supplements, drug industries, pesticides, and herbicides, as well as nanoparticles. Chemopreventive strategies are outlined as a global health trend for the anti-genotoxicity of interesting herbal extract compounds determined by SMART assay. The successful application of Drosophila for high-throughput screening of mutagens is also discussed as a future perspective.

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“…Various combination toxicity studies were earlier performed on synthetic pyrethroids, but the data regarding the toxicological effects of PBO and tetramethrin addition into the synthetic pyrethroid formulations are very limited, and most of them were obtained from in vitro studies (Diel et al, 1999; Grosman, 2007; Grosman and Diel, 2005; Matoba et al, 1998a, 1998b; Meacham et al, 2008; Motomura and Narahashi, 2001). In this regard, the aim of the present study was to investigate the effects of the synergist PBO and the knockdown agent tetramethrin combinations on the 28-day subacute oral toxicity of the synthetic pyrethroids cypermethrin, alphacypermethrin, and deltamethrin in Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Subacute oral toxicity of combinations of selected synthetic pyrethroids, piperonyl butoxide, and tetramethrin in rats

et al. 2013

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In this study, 70 Wistar rats were randomly divided into seven equal groups (six experimental and one control), which consisted of animals belonging to both sexes. Different combinations of insecticides were administered daily to the experimental groups (group 1: cypermethrin + piperonyl butoxide (PBO); group 2: alphacypermethrin + PBO; group 3: deltamethrin + PBO; group 4: cypermethrin + PBO + tetramethrin; group 5: alphacypermethrin + PBO + tetramethrin; and group 6: deltamethrin + PBO + tetramethrin) for 28 days. During the study period, mortality and serious clinical findings were not observed in any animal. However, feed consumptions decreased in groups 1 and 3 (p < 0.05). Red blood cells, white blood cells, and hemoglobin levels, especially in cypermethrin and alphacypermethrin groups (groups 1, 2, and 4), were found to be higher than the control group (p < 0.05). Furthermore, biochemical changes related to liver, kidney functions, and protein metabolism occurred in males of almost all the groups. Relative liver and kidney weights of the male animals increased in the cypermethrin and alphacypermethrin groups (p < 0.05). The most common finding observed during the histopathological examination of all the experimental groups was centrilobular degeneration in the liver. It was concluded that although clinical symptoms were not observed, synthetic pyrethroid, synergist, and knockdown agent combinations might cause serious abnormalities when administered in certain doses in mammalians.

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Influence of pyrethroids and piperonyl butoxide on histamine release from isolated rat mast cells

Cited by 6 publications

References 21 publications

Karate Zeon Pestisitinin Mutajenik Aktivitesinin Ames Testi ile Değerlendirilmesi

Karate Zeon Pestisitinin Mutajenik Aktivitesinin Ames Testi ile Değerlendirilmesi

Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing—A Review

Subacute oral toxicity of combinations of selected synthetic pyrethroids, piperonyl butoxide, and tetramethrin in rats

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