Influence of Quercetin and Dihydroquercetin on Some Functional Parameters of Rat Liver Mitochondria

Gayibov, Ulugbek; Gayibova, Sabina; Pozilov, Mamurjon Komiljonovich; Tuxtaeva, Feruza Sh.; Yusupova, Umida R.; Djabbarova, Gulchehra M.-K.; Mamatova, Zulayho A.; Ergashev, Nurali A.; Aripov, T. F.

doi:10.15414/jmbfs.2924

Cited by 6 publications

(4 citation statements)

References 25 publications

(27 reference statements)

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“…The mPTP blocker was reported to inhibit mitochondrial contraction by cyclosporin A (Basso et al 2008). It has been detected that the flavonoid dihydroquercetin obtained for the experiment, has an activating effect on the mitochondrial ATP-dependent potassium channel (Gayibov et al 2021). Concentrations of 10-120 μM isoquinoline alkaloid F-18 have been considered to inhibit mitochondrial edema.…”

Section: Discussionmentioning

confidence: 99%

Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Ernazarov

Pozilov

Asrarov

et al. 2023

Nova Biotechnol. Chim.

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In the current research paper, the flavonoid dihydroquercetin, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) and 2-(3,4-dihydroxyphenyl)-6-(1-(2´-bromine-4´, 5´-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2 (1N)-il) methyl-3. The effects of 5,7-trigidroxychroman-4-on (DHQ-11) conjugate on rat liver mitochondrial calcium megachannels and on lipid peroxidation (LPO) induced using Fe2+/citrate were investigated in vitro experiments. White male rats weighing 180-200 grams were used in the experiments. It was found that the DHQ-11 conjugate was identified to have an inhibitory effect on rat liver mitochondria to calcium megachannels and peroxidation of lipids induced by Fe2+/citrate. The inhibitory properties of DHQ-11 conjugate on hepatic mitochondrial calcium megachannels and mitochondrial membrane lipid peroxidation were identified as active against dihydroquercetin and the F-18 isoquinoline alkaloid.

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Section: Discussionmentioning

confidence: 99%

Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Ernazarov

Pozilov

Asrarov

et al. 2023

Nova Biotechnol. Chim.

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“…Hence, in the presence of diazoxide, SFL and narcissine in the incubation medium, their cardiac mitochondrial activating property was found to increase (Figure 3). Up to date, many studies have been conducted on the properties of activators of the cardiomyocytes mitoK ATPchannel [6,7,10,11]. However, the effect of SFL and narcissine on the mitoK ATP -channel of the rat heart in the ischemic model has not been studied.…”

Section: Figure 2 Effect Of Sfl (A) and Narcissine (B) Flavonoids On ...mentioning

confidence: 99%

“…Such substances that activate the K ATP -channel have been shown to depolarize the cardiac mitochondria [11]. However, since the metabolic activators of the mitoK ATP -channel are synthetic analogues, they may cause disruption of the regulation of cellular ion transport systems in relation to natural active substances [6].…”

Section: Figure 2 Effect Of Sfl (A) and Narcissine (B) Flavonoids On ...mentioning

confidence: 99%

Effect of Soforaflavonozide and Narcissine Flavonoids on ATP-dependent Potassium Channels of Rat Cardiac Mitochondria in the Ischemia Model

Ismoilovich¹,

Komiljonovich²,

O’g’li³

et al. 2022

AJBLS

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In this study, in vitro and in vivo experiments, it was studied soforaflavonozide (SFL) isolated from Alhagi canescens (Regel) B. Keller & Shap (Fabaceae (Leguminosae)), and narcissine isolated from Crocus sativus L. belonging to Iridaceae family. It was studied the effect of narcissine isolated from the plant on ATP-dependent potassium channel (mitoK ATP -channel) activity in rat cardiac mitochondria. Animals of experimental group were divided into 4 groups: I control group (healthy), II experimental group (ischemia model), III experiment group (ischemia + narcissin), IV experimental group (ischemia + SFL). In rats with ischemia a 0.1 ml 0.1% solution of 100 mg/kg adrenaline was administered subcutaneously and peritoneally for 3 days in relative to body weight. The rats that underwent the ischemia model were given oral administration of 10 mg/kg of narcissine flavonoid to group III and 10 mg/kg of SFL flavonoid to group IV orally for 7 days. After that, in the experimental animals carried out electrocardiogram. Mitochondria from rat heart tissue were isolated by differential centrifugation. Cardiac mitoK ATP -channel activity in the presence of ATP in an incubation medium was studied at concentrations of 10-50 µM of SFL and narcissine. Concentrations of 50 µM of SFL and narcissus and 30 µM of diazoxide were also found to have an activating effect on the mitochondrial channel of the heart. In the adrenaline-induced ischemia model, it was found that narcissine and SFL flavonoids restored the mitochondrial conduction permeability of the rat heart.

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“…In the reaction of DPPH with gossitan t50 at 17°C -90 s (with a 1:1 ratio of basic substance to DPPH). For comparison, the data t50 at 20°C with an equimolar ratio of dihydroquercetin and unithiol to DPPH was 105 and 590 seconds, respectively (Gayibov et al, 2021). Analysis of the kinetic curves shows that most of the DPPH molecules are restored in the first 3 minutes of the reaction, and then the reduction reaction proceeds more slowly.…”

Section: The Antiradical Activity Of the Gossitanmentioning

confidence: 99%

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

Pozilov¹,

Gayibov²,

Asrarov³

et al. 2022

J microb biotech food sci

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The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) and antiradical activity of rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways of correction of detected membrane damages with the use of gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that the rate of respiration of liver mitochondria in states V3 and V4 increases during STZ-induced diabetes, which significantly reduces the respiratory control (RC) and ADP/O coefficients in comparison with the control. The findings suggest that the uncoupling of respiration and oxidative phosphorylation takes place during STZ-induced diabetes. It was shown that in the conditions of STZ-induced diabetes, the rate of swelling of rat liver mitochondria is higher than of the healthy ones; this means that mPTP of rat liver mitochondria is in the open state. Gossitan recovers mPTP to the normal condition, thereby removing the effect of STZ on mitochondria. Gossitan (per os dose is 10 mg/kg of body weight, during 8 days) eliminates the detected functional disorders of rat liver mitochondria, probably due to its antioxidant properties.

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Influence of Quercetin and Dihydroquercetin on Some Functional Parameters of Rat Liver Mitochondria

Cited by 6 publications

References 25 publications

Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Effect of Soforaflavonozide and Narcissine Flavonoids on ATP-dependent Potassium Channels of Rat Cardiac Mitochondria in the Ischemia Model

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

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