Influence of race and ethnicity on in vitro fertilization outcomes: systematic review

Humphries, Leigh Ann; Chang, Olivia H.; Humm, K.C.; Sakkas, Denny; Hacker, Michele R.

doi:10.1016/j.ajog.2015.09.002

Cited by 89 publications

(56 citation statements)

References 65 publications

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“…(2011) , the only author reporting ethnicity, had 6% of Hispanic women among their subjects, against most Hispanic women in our study, which was not registered, for demographic reasons, but expected. In a recent systematic review, performed by Humphries et al (2016) , the authors concluded that there are significant disparities in pregnancy and live birth rates after ART by ethnicity; however, most available studies are limited by sample size, selection bias (different definitions of race and ethnicity), extensive missing data and inadequate adjustment for confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Outcome of assisted reproductive technology in overweight and obese women

Mackenna¹,

Schwarze²,

Crosby³

et al. 2017

JBRA Assisted Reproduction

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ObjectiveThe main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes.MethodsWe used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number of oocytes retrieved and embryos transferred, clinical pregnancy, live birth and miscarriage rates from 107.313 patients undergoing autologous IVF and ICSI during four years; a multivariable analysis was performed to determine the effect of BMI on cancellation, oocytes retrieved, pregnancy, live birth and miscarriage, adjusting for age, number of embryos transferred and embryo developmental stage upon embryo transfer, when appropriate.ResultsThe prevalence of overweight and obesity was 16.1% and 42.4%, respectively; correcting for age of female partner, overweight and obesity were associated to an increase in the odds of cancellation and to a lower mean number of oocytes retrieved; after adjusting for age, number of embryos transferred and stage of embryo development at transfer, we found that the BMI category was not associated to a change in the likelihoods of pregnancy, live birth and miscarriage.ConclusionsThe prevalence of obesity among women seeking ART in Latin America is surprisingly high; however, BMI does not influence the outcome of ART performed in these women.

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Section: Discussionmentioning

confidence: 99%

Outcome of assisted reproductive technology in overweight and obese women

Mackenna¹,

Schwarze²,

Crosby³

et al. 2017

JBRA Assisted Reproduction

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“…The following independent variables were included in each model: age 19 , race 20 , ethnicity 21 , education 22 , marital status, BMI 23 , current or recent smoker 24 , menstrual regularity, contraceptive use, history of PCOS 25 , primary infertility, importance of post-surgical pregnancy, and surgical procedure.…”

Section: Methodsmentioning

confidence: 99%

Contraception and Conception After Bariatric Surgery

Menke

King

White

et al. 2017

Obstetrics &Amp; Gynecology

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Objective To examine contraceptive practices and conception rates after bariatric surgery. Methods The Longitudinal Assessment of Bariatric Surgery-2 is a multicenter, prospective cohort study of adults undergoing first-time bariatric surgery as part of routine clinical care at 10 U.S. hospitals. Recruitment occurred between 2005 and 2009. Participants completed preoperative and annual post-surgical assessments for up to seven years until January 2015. This report was restricted to women 18–44 years old with no history of menopause, hysterectomy, or estrogen and progesterone therapy. Primary outcomes were self-reported contraceptive practices, overall conception rate and early (<18 months) post-surgical conception. Contraceptive practice (no intercourse, protected, unprotected, or tried to conceive) was classified based on the preceding year. Conception rates were determined from self-reported pregnancies. Results Of 740 eligible women, 710 (95.9%) completed follow-up assessment(s). Median (IQR) preoperative age was 34 (30–39) years. In the first postsurgical year, 12.7% (95%CI, 9.4–16.0) of women had no intercourse, 40.5% (95%CI, 35.6–45.4) had protected intercourse only, 41.5% (95%CI, 36.4–46.6) had unprotected intercourse while not trying to conceive, and 4.3% (95%CI, 2.4–6.3) tried to conceive. The prevalence of the first three groups did not significantly differ across the 7 years of follow-up (P for all >.05); however, more women tried to conceive in the second year (13.1%, 95%CI, 9.3–17.0; P<0.001). The conception rate was 53.8 (95%CI, 40.0–71.1) per 1,000 woman-years across follow-up (median [IQR]: 6.5 [5.9, 7.0] years); 42.3 (95%CI, 30.2–57.6)/1,000 woman-years in the 18 months after surgery. Age (ARR 0.41, [95% CI, 0.19–0.89] per 10 years, P=0.03), being married or living as married (ARR 4.76, [95% CI, 2.02–11.21], P<0.001), and rating future pregnancy as important preoperatively (ARR 8.50, [95% CI, 2.92–24.75], P<0.001) were associated with early conception. Conclusion Post-surgical contraceptive use and conception rates do not reflect recommendations for an 18-month delay in conception after bariatric surgery. Clinical Trial Registration ClinicalTrials.gov, NCT00465829.

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“…A Poisson mixed model with robust error variance with a person-level random intercept was used to test and estimate associations between preoperative history of infertility and nulliparity with early conception with a person-level random intercept. Analysis was repeated controlling for the following potential preoperative confounders: age [11,21] , race [22] , ethnicity [23] , education [24] , marital status [11] , BMI [25] , current or recent smoker [26] , menstrual regularity, any contraceptive use, history of PCOS [27] , and surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

Conception rates and contraceptive use after bariatric surgery among women with infertility: Evidence from a prospective multicenter cohort study

Menke

King

White

et al. 2019

Surgery for Obesity and Related Diseases

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Background: Lack of prospective trials have resulted in a dearth of information regarding postbariatric surgery conception rates in women with a preoperative history of infertility. Objective: To examine associations between preoperative history of infertility and postbariatric surgery conception. Setting: A multicenter cohort study at 10 United States hospitals (2006-2009). Methods: Participants completed a preoperative reproductive health questionnaire, with annual postoperative assessments for up to 7 years until January 2015. This report was restricted to women 18-to 44-years old with no history of menopause, hysterectomy, or hormone replacement therapy. The primary outcomes were postoperative (0 to < 90 mo) conception rate, early conception rate (0 < 18 mo), and postoperative unprotected intercourse with a male partner while not trying to conceive.

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Influence of race and ethnicity on in vitro fertilization outcomes: systematic review

Cited by 89 publications

References 65 publications

Outcome of assisted reproductive technology in overweight and obese women

Outcome of assisted reproductive technology in overweight and obese women

Contraception and Conception After Bariatric Surgery

Conception rates and contraceptive use after bariatric surgery among women with infertility: Evidence from a prospective multicenter cohort study

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