Outcome of assisted reproductive technology in overweight and obese women

Abstract

ObjectiveThe main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes.MethodsWe used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number of oocytes retrieved and embryos transferred, clinical pregnancy, live birth and miscarriage rates from 107.313 patients undergoing autologous IVF and ICSI during four years; a multivariable analysis was performed to determine the effect of BMI on cancellation, oocytes retrieved, pregnancy, live birth and miscarriage, adjusting for age, number of embryos transferred and embryo developmental stage upon embryo transfer, when appropriate.ResultsThe prevalence of overweight and obesity was 16.1% and 42.4%, respectively; correcting for age of female partner, overweight and obesity were associated to an increase in the odds of cancellation and to a lower mean number of oocytes retrieved; after adjusting for age, number of embryos transferred and stage of embryo development at transfer, we found that the BMI category was not associated to a change in the likelihoods of pregnancy, live birth and miscarriage.ConclusionsThe prevalence of obesity among women seeking ART in Latin America is surprisingly high; however, BMI does not influence the outcome of ART performed in these women.

In Vitro Fertilization Success and Associated Factors: A Prospective Cohort Study

“…We also did not find any relationship between BMI and IVF success which is in harmony with the results of a study conducted by MacKenna et al in Latin America. In the study by MacKenna which was conducted on a sample of women with a high prevalence of obesity, BMI did not influence the outcome of ART (27).…”

Value of serum and follicular fluid Sirt1,Sirt2 protein levels in predicting the outcome of assisted reproduction

“…There is no obesity patient in our group. The sudy of Antonio MacKenna etc showed that BMI does not influence the outcome of ART performed in women of Latin America (14). Also some study (15) showed that among women undergoing first FET with high-quality embryo transfer, obesity was associated with worse IVF outcomes, but not overweight.…”

Does low BMI affect ART outcomes?

“…However, the authors noted that one of the limitations of the study was the inability to adjust for patient race across BMI categories. In a study conducted in a Latin American population, MacKenna et al. (2017) did not observe a correlation of low weight with IVF outcomes.…”

“…However, evidence of the effects of low BMI on ART outcomes is conflicting. On one hand, low BMI has been associated with a reduced probability of achieving pregnancy, increased risk of miscarriage and reduced live birth rate ( Wang et al , 2000 ; Wittemer et al , 2000 ; Veleva et al , 2008 ; Singh et al , 2012 ; Cai et al , 2017 ); on the other hand, several studies have found no effect on treatment outcomes ( Lashen et al , 1999 ; Fedorcsák et al , 2004 ; Li et al , 2010 ; Provost et al , 2016 ; MacKenna et al , 2017 ). Nevertheless, some studies report that patients with low BMI have worse clinical outcomes than patients with normal BMI, although these results were not statistically significant.…”