2012
DOI: 10.1039/c2sm06391c
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Influence of red blood cells on nanoparticle targeted delivery in microcirculation

Abstract: Multifunctional nanomedicine holds considerable promise as the next generation of medicine that allows for targeted therapy with minimal toxicity. Most current studies on Nanoparticle (NP) drug delivery consider a Newtonian fluid with suspending NPs. However, blood is a complex biological fluid composed of deformable cells, proteins, platelets, and plasma. For blood flow in capillaries, arterioles and venules, the particulate nature of the blood needs to be considered in the delivery process. The existence of … Show more

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Cited by 174 publications
(148 citation statements)
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“…This work differs from previous studies in a number of ways. First, all previous experimental studies, with only two exceptions (7,38), assessed margination propensity based on the number density, or, more precisely, the fluorescence intensity, of fluorescent particles that adhered to the channel wall after a particle suspension and subsequently a buffer solution passed through the channel (3,(11)(12)(13)(14)(16)(17)(18)39). Although adhesion is related to margination, adhesion also depends on other factors such as hydrodynamic drag, the densities of ligands and receptors grafted onto the particle surface and the wall channel, the particle shape and contact orientation, and the particle size relative to the CFL (10,16,17,20,21).…”
Section: Introductionmentioning
confidence: 99%
“…This work differs from previous studies in a number of ways. First, all previous experimental studies, with only two exceptions (7,38), assessed margination propensity based on the number density, or, more precisely, the fluorescence intensity, of fluorescent particles that adhered to the channel wall after a particle suspension and subsequently a buffer solution passed through the channel (3,(11)(12)(13)(14)(16)(17)(18)39). Although adhesion is related to margination, adhesion also depends on other factors such as hydrodynamic drag, the densities of ligands and receptors grafted onto the particle surface and the wall channel, the particle shape and contact orientation, and the particle size relative to the CFL (10,16,17,20,21).…”
Section: Introductionmentioning
confidence: 99%
“…The RBC -RBC interaction is described by a Morse-type potential, which has been theoretically provided by Neu et al [100,101]. To prevent overlap between RBCs and NPs in the simulations, we adopt a Lennard-Jones potential for RBC -NP and NP -NP interactions [31,38]. To correctly capture the multiphase nature of the plasma-cell-NP mixtures, their interactions are also coupled with the Navier -Stokes equation for the fluid domain.…”
Section: Model and Methodologymentioning
confidence: 99%
“…The simulation and experimental results confirm that larger NPs (greater than 500 nm) can migrate into the 'cell-free layer', while smaller NPs (less than 200 nm) are mostly trapped between RBCs in the core region. However, to date, there is not a consensus on an optimal NP size for margination [31,34,37,38,40].…”
Section: S Parameter Effects On Margination Propensitymentioning
confidence: 99%
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“…The same simulator is also exploited in [24], where the authors describe a specific communication process happening inside blood vessels, atherogenesis. Another similar paper is [25], where a particle-cell hybrid model is developed to model nanoparticle transport, dispersion and binding dynamics in the blood. Finally, the authors in [26] focus on the interference aspects of the gold nanoparticles with the macrophage cells studied through a specific approach with microscopy techniques based on electrons and ions.…”
Section: Introductionmentioning
confidence: 99%