Influence of relative humidity during coating on polymer deposition and film formation

Macchi, E.; Felton, Linda A.

doi:10.1016/j.ijpharm.2016.05.063

Cited by 10 publications

(5 citation statements)

References 25 publications

(28 reference statements)

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“…9,10 Optimum ambient humidity and temperature must be maintained during the latex-based paint application procedure: if the humidity is too high, water evaporates slowly and defects develop, 11 whereas too low humidity means that paint film drying occurs too rapidly. 12 Flash corrosion usually takes place if the drying waterborne film is exposed to highly humid air. 13 Paint film formation by latex-based paints during water evaporation proceeds by the coalescence of polymeric particles, their deformation and, finally, diffusion of the polymeric chains between particles.…”

Section: Introductionmentioning

confidence: 99%

Waterborne coatings based on acrylic latex containing nanostructured ZnO as an active additive

2020

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This work was devoted to the study of the properties of an acrylate latex-based binder synthesised by semi-continuous emulsion polymerisation. Nanoparticles of zinc oxide (NPsZnO) in an amount of 1.5 wt.% with respect to the polymer content were added to the binder during the synthesis procedure. The binder was then homogenised with various anticorrosion pigments, fillers and additives to obtain model anticorrosion paints. In addition, model paints with expected enhanced antimicrobial resistance designed for the protection of mineral substrates were also formulated and prepared. The effects of NPsZnO on the physico-mechanical properties and on the chemical, anticorrosion and antimicrobial resistance of the paint films were examined. The properties of the paints based on the synthesised binders were also compared to those of a commercial acrylate-type binder. The results show that incorporation of NPsZnO into the latex during the synthesis provided stable polymeric dispersions exhibiting physico-chemical, mechanical and anticorrosion properties that were superior to those of a blank binder (containing no nanoparticles) as well as to the commercial binder. It was also demonstrated that the binder with NPsZnO provided anticorrosion paints that are usable as coatings for environments with a moderate corrosion burden as well as paints for interior applications with reduced biocide contents.

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Section: Introductionmentioning

confidence: 99%

Waterborne coatings based on acrylic latex containing nanostructured ZnO as an active additive

2020

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“…The control system monitors the machine while the automation ensuing batch-to-batch quality compliance and consistency 14 . Modern coaters use computer software designed to make the process more automate and efficient (from charging to discharging) and/or to monitor the number of parameters such as the spin-rate of the drum, coating time 44 , substrate surface flow velocity 17,45 , spray-rate 24 , flow rate and temperature of inlet air 24 , process humidity 46,47 , coating weight gain 42,48 , coating attributes 49,52 and many more 16,23,53,55 . In addition, computerization can store process instructions or recipes that produce specific results 12 .…”

Section:  Parametersmentioning

confidence: 99%

“…The fact is growingly a concern to regulatory authorities due to their untoward effects on health 14, 38, 46, 47. Water has low volatility comparing VOSs. Thus, it will require better drying capacity and contributing a higher cost of energy to the CPR 14,38,46,47 .…”

Section: Effect Of Residual Moisturementioning

confidence: 99%

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2022

IJPSR

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The presentation of this work aims to update readers on issues associated with coating pan (CPN), having applicability in the pharmaceutical field. The coating process (CPR) is an important pharmaceutical unit operation that finds pertinence in various product areas extending from conventional (immediate) release to modified release. The CPR involves the substrate coating by spraying the coating material in liquid medium onto them, kept in motion using either CPN or fluid bed processor (FBP). The FBP is used preferably for coating of multi-particulates and powders and rarely for tablets, while CPNs are used for coating tablets and capsules, thus are in extensive use. Conventional CPNs and perforated coating pan (PPN) are the major categories of the CPNs. The PPNs are preferred for the products that call for improved drying efficiency where the drying efficiency of the drying air (DA) is highest. The perforated pan system (PPNSY) is used in the coating system based on the aqueous solvent, with preference to that based on the volatile organic solvent (VOS). Comprehensive reviews on the technical aspect of CPNs are rare, necessitating this work. Thereupon the information was studied, summarised, and attempted to be presented for convenience and enrichment of the readers. The contained information will be updating pharmaceutical professionals in this regard. INTRODUCTION:Coating is a process in which a dry outer layer of coat is applied over a substrate (commonly solid particle or dosage form) to provide certain benefits over uncoated form, that range from protecting products (from environmental factors such as air, light, temperature, gastric acid 1, 2 , moisture 2 , to simplify production 3, 4 , product identification 4 , 5 ,

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“…The dry rate plays a critical role in achieving an acceptable coating film [50]. A rapid loss of water may not allow for the development of the necessary capillary force between the deposited coating particles and the surface of the cores, thus inhibiting the deformation and coalescence of the polymer particles, thereby resulting in a weaker moisture-proof film.…”

Section: Coating Processmentioning

confidence: 99%

An Update of Moisture Barrier Coating for Drug Delivery

Yang

Feng

et al. 2019

Pharmaceutics

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Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings.

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Influence of relative humidity during coating on polymer deposition and film formation

Cited by 10 publications

References 25 publications

Waterborne coatings based on acrylic latex containing nanostructured ZnO as an active additive

Waterborne coatings based on acrylic latex containing nanostructured ZnO as an active additive

Untitled

An Update of Moisture Barrier Coating for Drug Delivery

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