Influence of selenium therapy on liver microcirculation after warm ischemia/reperfusion: an intravital microscopy study

Zapletal, C.; Heyne, S.; Golling, M.; Kraus, Thomas; Gebhard, M. M.; Herfarth, Ch.; Klar, E.

doi:10.1016/s0041-1345(00)02292-2

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…The benefits of selenium supplementation in improving the body’s selenium status has been highlighted in numerous selenium-deficient animal models as well as human trials [29,30,31,32]. In particular, therapeutic selenium administration has been shown as beneficial in several in vivo disease models where oxidative stress is prominent, including atherosclerosis [33,34,35,36] and various I/R pathologies such as renal and liver I/R injury [37,38]. The promise of selenium supplementation as a suitable therapeutic agent for the prevention of CVD is shown by the association of low selenium levels with the incidence of CVD [39,40,41] with low plasma concentrations of selenium associated with poor clinical outcome, accompanying future CVD deaths in ACS patients [40].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

et al. 2019

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Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury. This partly arises from the presence of activated phagocytes releasing myeloperoxidase (MPO) and its production of hypochlorous acid (HOCl). The dietary supplement selenomethionine (SeMet) has been shown to bolster endogenous antioxidant processes as well as readily react with MPO-derived oxidants. The aim of this study was to assess whether supplementation with SeMet could modulate the extent of cellular damage observed in an in vitro cardiac myocyte model exposed to (patho)-physiological levels of HOCl and an in vivo rat model of cardiac I/R injury. Exposure of the H9c2 cardiac myoblast cell line to HOCl resulted in a dose-dependent increase in necrotic cell death, which could be prevented by SeMet supplementation and was attributed to SeMet preventing the HOCl-induced loss of mitochondrial inner trans-membrane potential, and the associated cytosolic calcium accumulation. This protection was credited primarily to the direct oxidant scavenging ability of SeMet, with a minor contribution arising from the ability of SeMet to bolster cardiac myoblast glutathione peroxidase (GPx) activity. In vivo, a significant increase in selenium levels in the plasma and heart tissue were seen in male Wistar rats fed a diet supplemented with 2 mg kg−1 SeMet compared to controls. However, SeMet-supplementation demonstrated only limited improvement in heart function and did not result in better heart remodelling following I/R injury. These data indicate that SeMet supplementation is of potential benefit within pathological settings where excessive HOCl is known to be generated but has limited efficacy as a therapeutic agent for the treatment of heart attack.

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Section: Introductionmentioning

confidence: 99%

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

et al. 2019

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“…GPx together with superoxide dismutase (SOD) and catalase form part of the cellular antioxidant defense system against reactive molecules and free radicals [9]. It has been shown that selenium has beneficial effects in preventing I/R injury in heart [10], lung [11], liver [12], and kidney [13].…”

Section: Introductionmentioning

confidence: 99%

The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury

et al. 2005

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This study was designed to investigate the effect of selenium on ipsilateral and contralateral testicular damage after unilateral testicular torsion/detorsion (T/D). Thirty-two male rats were divided into four groups, each containing eight rats. Torsion was created by rotating the right testis 720 degrees in a clockwise direction. Group 1 underwent sham operation to determine basal values for biochemical and histopathological evaluation. Sham operation was performed in group 2, and sodium selenate (0.2 mg/kg) was given intraperitoneally. Group 3 served as a T/D group, receiving 4-h torsion and 4-h detorsion. Similarly, in group 4 sodium selenate (0.2 mg/kg) was injected intraperitoneally 20 min before detorsion. Bilateral orchiectomies were performed for measurement of tissue malondialdehyde (MDA) levels and superoxide dismutase (SOD) activities and histopathologic examination. The results were compared statistically. The highest MDA and the lowest SOD values were determined in both testes in group 3. There were statistically significant differences in MDA levels and SOD activities in group 3 compared with group 4. Specimens from group 3 had a significantly greater histologic injury than other groups. These results suggest that ischemia-reperfusion injury occurred in both testes after unilateral testicular T/D and that selenium administration before detorsion prevents reperfusion injury in testicular torsion.

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“…The protective effect of selenium against arrhythmo-genesis is seen in the reduction of oxidative stress, decreased connexin-43 dephosphorylation, and, as a result reduced electrical uncoupling at gap junctions [16]. This protective effect against I/R injury was also reported in the liver and the brain, showing reduced edema and microglial cell infiltration, and, possibly, salvaging the cells of the ischemic penumbra by reducing ROS flux [19,20]. …”

Section: Discussionmentioning

confidence: 99%

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

et al. 2010

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Objective-Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.Methods-Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.Results-In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0 μg/L versus 71.5 μg/L; P < 0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P = 0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.Conclusions-Low selenium concentration was associated with future cardiovascular death in patients with ACS.

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Influence of selenium therapy on liver microcirculation after warm ischemia/reperfusion: an intravital microscopy study

Cited by 9 publications

References 6 publications

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

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