During the process of detecting gravitational waves in space, addressing noise issues caused by terrestrial vibrations, natural environmental changes, and the factors intrinsic to the detectors, this paper proposes a multiscale variational mode adaptive denoising algorithm based on momentum gradient descent. This algorithm integrates momentum factors and multiscale concepts into the variational mode algorithm to resolve the issue of multiple local optima encountered during operation, reduce oscillations in regions with large or unstable gradient changes, and improve convergence speed. Additionally, the algorithm combines the least mean squares algorithm to automatically adjust weights, thereby mitigating the impact of noise, addressing the issue of noise from multiple and random sources, effectively suppressing noise in the gravitational wave signal, and enhancing the quality and reliability of the gravitational wave signal. Experimental results demonstrate that this algorithm performs better than other algorithms in noise suppression, effectively reducing noise in gravitational wave signals and meeting the noise suppression requirements for space-based gravitational wave detection.