Influence of sex steroids on inflammation and bone metabolism

Shiau, Harlan J.; Aichelmann-Reidy, Mary E.; Reynolds, Mark A.

doi:10.1111/prd.12033

Cited by 52 publications

(34 citation statements)

References 157 publications

(156 reference statements)

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“…The composite effect of sex-specific genetic architecture and the circulating levels of sex-steroid hormones closely parallels differences in the immune response and may account for corresponding sex-related differences in risk for chronic periodontitis, with men exhibiting greater susceptibility than women (31). Furthermore, smoking is an established risk factor for poor oral health (32).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors for periodontitis among adults in China, 2010

Zhang

Wang

et al. 2014

Global Health Action

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BackgroundAlthough the interrelationship between poor oral health and chronic diseases is well established, few related studies are available in China. In this study, the prevalence of severe periodontitis and its association with chronic diseases among adults in China have been explored.DesignDuring China's 2010 Chronic Disease and Risk Factor Surveillance (CCDRFS) survey among adults aged 18 and older, 3 out of 162 surveillance points and the entire sample from each point (600×3=1,800 subjects) were selected as pilot study sites in which oral examination was performed. Basic demographic information, chronic diseases status, and results of oral examination were collected from 2010 CCDRFS data. A standard oral examination was conducted by trained staff. Periodontitis was defined as moderate (4–5 mm pockets) or severe (≥6 mm pockets). Chronic disease status was determined by using standard methods and criteria. Multivariate logistic analysis was used to identify the independent association of various factors with severe periodontitis.ResultsOf 1,800 subjects, 1,728 subjects (96%) provided complete information. The prevalence of severe periodontitis was 1.9% (32/1,728) (95% CI=1.2–2.5). In multivariate model, participants with diabetes were 2.4 times (OR=2.4, 95% CI=1.1–5.6) more likely to have severe periodontitis. Being male was significantly associated with severe periodontitis (OR=3.5, 95% CI=1.6–7.7). Living in a rural area was related to an increased chance of having severe periodontitis (OR=2.1, 95% CI=1.0– 4.9). Attainment of at least 6 years of education was inversely associated with severe periodontitis (OR=0.3, 95% CI=0.1–0.8).ConclusionsAccording to this pilot project, prevalence of severe periodontitis was low. Control measures should be particularly emphasized for high-risk groups such as less educated people (<6 years of education), people living in rural areas, men, and diabetes patients. Population-based studies, including oral examination by trained staff, are feasible and should be done in order to understand the burden of periodontitis and to provide an effective response to this key oral health issue.

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Section: Discussionmentioning

confidence: 99%

Prevalence and predictors for periodontitis among adults in China, 2010

Zhang

Wang

et al. 2014

Global Health Action

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“…There is substantial evidence supporting the role of sex steroids levels in influencing periodontal health (Kumar, 2013;Mariotti & Mawhinney, 2013;Mascarenhas, Gapski, Al-Shammari, & Wang, 2003;Shiau, Aichelmann-Reidy, & Reynolds, 2014). The periodontal tissues are indeed influenced by sex hormones, and both "systemic" and "periodontium-specific" mechanisms are likely to be involved.…”

Section: Possible Mechanisms Of the Associationsmentioning

confidence: 99%

Hormone‐related events and periodontitis in women

Romandini

Shin

Romandini

et al. 2020

J Clinic Periodontology

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Aim While the short‐term effects of hormonal events on gingival inflammation have been well described, long‐term effects on the periodontium have received less attention. The aim of this cross‐sectional population‐based study was to evaluate the association between hormone‐related events and periodontitis in a representative sample of the postmenopausal women of South Korea. Materials and Methods A total of 10,273 postmenopausal women representative of 6.1 million of Koreans were examined. Periodontitis and severe periodontitis were defined according to the Community Periodontal Index (CPI ≧ 3 and CPI = 4, respectively). Univariate and multivariate regression analyses using 3 different models were applied controlling for age, smoking, marital status, educational level, income, BMI, hypertension, stress and frequency of toothbrushing. Results Severe periodontitis was directly associated with a longer reproductive life (p‐trend = .027) and with a longer duration of breastfeeding (48–72 vs. 1–17 months: OR = 1.49; 95% CI: 1.01–2.21). Conversely, early menopausal age (<46 vs. 49–50 years: OR = 0.74; 95% CI: 0.56–0.97), history of artificial menopause (OR = 0.72; 95% CI: 0.53–0.97), having had more than 6 pregnancies (vs. 4: OR = 0.73; 95% CI: 0.55–0.97), having had more than three abortions (vs. 0: OR = 0.51; 95% CI: 0.28–0.93) and having had the first birth age >26 years (vs. <21 years: OR = 0.71; 95% CI: 0.52–0.97) were inversely associated with severe periodontitis. Conclusions In this large nationally representative population, severe periodontitis was related to menopausal age, reproductive life length, number of pregnancies/abortions, first birth age and breastfeeding duration, while it was not to oral contraceptive and hormone replacement therapy usages.

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“…Plasma B cells produce antibodies. pathogens, antibody production, and even immune organ development [76][77][78][79][80][81]. Gonadal hormones act to organize aspects of the immune system during development [82].…”

Section: Hormonesmentioning

confidence: 99%

Inflaming sex differences in mood disorders

Rainville

Hodes

2018

Neuropsychopharmacol

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Men and women often experience different symptoms or rates of occurrence for a variety of mood disorders. Many of the symptoms of mood disorders overlap with autoimmune disorders, which also have a higher prevalence in women. There is a growing interest in exploring the immune system to provide biomarkers for diagnosis of mood disorders, along with new targets for developing treatments. This review examines known sex differences in the immune system and their relationship to mood disorders. We focus on immune alterations associated with unipolar depression, bipolar depression, and anxiety disorders. We describe work from both basic and clinical research examining potential immune mechanisms thought to contribute to stress susceptibility and associated mood disorders. We propose that sex and age are important, intertwined factors that need to be included in future experimental designs if we are going to harness the power of the immune system to develop a new wave of treatments for mood disorders.

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Influence of sex steroids on inflammation and bone metabolism

Cited by 52 publications

References 157 publications

Prevalence and predictors for periodontitis among adults in China, 2010

Prevalence and predictors for periodontitis among adults in China, 2010

Hormone‐related events and periodontitis in women

Inflaming sex differences in mood disorders

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