Influence of Short-Chain Fatty Acids on Iron Absorption by Proximal Colon

Bouglé, D.; Vaghefi-Vaezzadeh, N; Roland, Nathalie; Bouvard, G.; Arhan, Pierre; Bureau, F.; Neuville, Dominique; Maubois, Jean‐Louis

doi:10.1080/003655202320378176

Cited by 71 publications

(62 citation statements)

References 24 publications

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“…Furthermore, animal studies have shown that the short chain fatty acids, in particular propionate seem to increase the absorption of iron in the colon proximal 2 . This may indicate a potential mechanism whereby ingestion of prebiotics increases the bioavailability of dietary iron.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, iron absorption through the large intestine may contribute to the recovery from anemia in iron deficient rats 8,9 . It has indeed been shown that the lower digestive tract, especially the proximal colon, can also be an important site of iron absorption when the absorption in the small intestine is insufficient 2,3,8 as may be the case after gastrectomy 7 . Furthermore, rat studies have shown that short-chain fatty acids, and in particular propionate, appears to play a role in the increased absorption of iron in the proximal colon 2 .…”

Section: Introductionmentioning

confidence: 99%

“…It has indeed been shown that the lower digestive tract, especially the proximal colon, can also be an important site of iron absorption when the absorption in the small intestine is insufficient 2,3,8 as may be the case after gastrectomy 7 . Furthermore, rat studies have shown that short-chain fatty acids, and in particular propionate, appears to play a role in the increased absorption of iron in the proximal colon 2 . Such observation suggests that ingestion of prebiotics might increase the bioavailability of dietary iron.…”

Section: Introductionmentioning

confidence: 99%

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A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Santos¹,

Tsuboi²,

Araújo³

et al. 2011

ABCD, arq. bras. cir. dig.

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headings -Prebiotics. Gastrectomy. Iron. Anemia. Rats.abstRact -Background -The ingestion of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), leads to an increase in iron absorption and promotes recovery from anemia in gastrectomized rats. Aim -To study whether GOS + PDX stimulate iron absorption in gastrectomized and normals rats. Methods -Rats were laparotomized (sham-operated control) and partially gastrectomized (Billroth II) in groups of 20 each. Animals from both treatments were subsequently fed a control diet (AIN-93M) or the same diet supplemented with GOS and PDX (25 g/Kg of diet each) for eight weeks. They were divided into four subgroups, i.e., sham-operated and gastrectomized without GOS + PDX, sham-operated and gastrectomized with GOS + PDX. Two rats died during the experiment. All gastrectomized rats received an intramuscular injection of vitamin B-12 every two weeks. Hematocrit (HCT) and hemoglobin concentration (HGB) were measured at the start and on day 30 and 56 days after the start of feeding. On the final day of the study, total blood was collected for determination of serum iron concentration. Results -In the diet with GOS + PDX, iron excretion in feces was significantly lower than without the prebiotics. Apparent iron absorption and serum iron was higher in the GOS + PDX fed groups (both sham operated and gastrectomized) than in the non-GOS + PDX fed groups. The HCT and HGB concentrations were significantly lower in gastrectomized rats than in the control group, however, GOS + PDX feeding improved HGB levels in this group. ConclusionThe association of the GOS + PDX increase absorption of iron in sham-operated and gastrectomized rats and still prevent postgastrectomy anemia.Resumo -Racional -Ratos gastrectomizados desenvolvem anemia, e a ingestão de galactooligossacarídeo (GOS) e a polidextrose (PDX) aumenta a absorção de ferro e promove a recuperação da anemia em ratos com deficiência de ferro. Objetivo -Avaliar se GOS e PDX estimulam a absorção de ferro em ratos gastrectomizados e normais. Métodos -Os ratos foram laparotomizadas (controle falso-operado) e parcialmente gastrectomizados (Billroth II) em grupos de 20 animais. Os animais de ambos os tratamentos foram posteriormente submetidos à dieta controle (AIN-93M) ou a mesma dieta suplementada com GOS e PDX (25 g/kg de dieta cada) durante oito semanas e divididos em quatro subgrupos: sham-operados e gastrectomizados sem GOS e PDX, sham-operados e gastrectomizados com GOS e PDX. Dois animais morreram durante o experimento. Todos os ratos gastrectomizados receberam uma injeção intramuscular de vitamina B-12 a cada duas semanas. Hematócrito (HCT) e concentração de hemoglobina (HGB) foram dosados no início e nos dias 30 e 56 dias após o início da alimentação. No último dia do estudo, o sangue total foi coletado para determinação da concentração de ferro sérico. Resultados -Na dieta com GOS e PDX a excreção de ferro nas fezes foi significativamente menor do que no grupo sem prebióticos. Absorção aparente de ferro e ferro sé...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Santos¹,

Tsuboi²,

Araújo³

et al. 2011

ABCD, arq. bras. cir. dig.

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show abstract

“…Furthermore, animal studies have shown that the short chain fatty acids, in particular propionate seem to increase the absorption of iron in the colon proximal. This may indicate a potential mechanism whereby ingestion of prebiotics increases the bioavailability of dietary iron 31 .…”

Section: Fecal Iron and Apparent Iron Absorptionmentioning

confidence: 95%

“…However, the sufficient iron has been reported to be absorbed in the large intestine for recovery from anemia in iron deficient rats 29,30 . It has been showed that the proximal colon, can be an important site of iron absorption when the absorption in the small intestine is insufficient 25,29,31 , such as after the gastrectomy 32 . Furthermore, animal studies have shown that the short chain fatty acids, in particular propionate seem to increase the absorption of iron in the colon proximal.…”

Section: Fecal Iron and Apparent Iron Absorptionmentioning

confidence: 99%

Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy

et al. 2010

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Purpose: To investigate whether polydextrose stimulates iron absorption in rats submitted to partial gastrectomy and sham operated. Methods: The rats were submitted to partial gastrectomy (Billroth II) or laparotomy (sham-operated control), in groups of 20 and 20 each respectively. The animals were fed with a control diet (AIN-93M) without polydextrose or a diet containing polydextrose (50g/Kg of diet) for eight weeks. They were divided into four subgroups: sham-operated and Billroth II gastrectomy and with or without polydextrose. Two animals died during the experiment. All rats submitted to gastrectomy received B-12 vitamin (intramuscular) each two weeks. The hematocrit and hemoglobin concentration were measured at the start and on day 30 and 56 after the beginning of the experimental period. At the end of the study, the blood was collected for determination of serum iron concentration. Results: The diet with polydextrose reduced the excretion of iron. Apparent iron absorption was higher in the polydextrose fed groups than in the control group. The haematocrit and haemoglobin concentration were lower after Billroth II gastrectomy rats fed the control diet as compared to the polydextrose diet groups. Conclusion: Polydextrose increase iron absorption and prevents postgastrectomy anemia. Key words: Prebiotics. Gastrectomy. Iron. Anemia. Rats. RESUMOObjetivo: Investigar se a polidextrose estimula a absorção de ferro em ratos submetidos à gastrectomia parcial e sham operados. Métodos: Os ratos foram submetidos à gastrectomia parcial (Billroth II) e à laparotomia (controle sham-operados) em grupos de 20 e 20 cada, respectivamente. Os animais foram alimentados com uma dieta controle (AIN-93M), sem polidextrose ou uma dieta contendo polidextrose (50g/kg de dieta) durante oito semanas. Foram divididos em quatro grupos: sham-operados e com gastrectomia BII e com ou sem polidextrose. Dois animais morreram durante o experimento. Todos os ratos com gastrectomia receberam vitamina B-12 (intramuscular) a cada duas semanas. O hematócrito e a hemoglobina foram dosados no início e nos dias 30 e 56 após o início do período experimental. No final do estudo, o sangue foi coletado para determinação da concentração de ferro sérico. Resultados: A dieta com polidextrose reduziu a excreção de ferro e a absorção de ferro aparente foi maior nos grupos alimentados com polidextrose do que no grupo controle. As dosagens de hematócrito e hemoglobina foram menores em ratos com gastrectomia alimentados com a dieta controle em relação aos grupos de dieta com polidextrose. Conclusão: A polidextrose aumenta a absorção do ferro e previne a anemia pós-gastrectomia.

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Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

et al. 2022

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Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short-and long-term health consequences. Among the underlying causes, certainly a reduced dietary intake and/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo studies suggests an increasingly important contribution from the gut microbiome. Commensal microorganisms can in fact regulate the levels of micronutrients, both by intervening in the biosynthetic processes and by modulating their absorption. This short narrative review addresses the pivotal role of the gut microbiome in influencing the bioavailability of vitamins (such as A, B, C, D, E, and K) and minerals (calcium, iron, zinc, magnesium, and phosphorous), as well as the impact of these micronutrients on microbiome composition and functionality. Personalized microbiome-based intervention strategies could therefore constitute an innovative tool to counteract micronutrient deficiencies by modulating the gut microbiome toward an eubiotic configuration capable of satisfying the needs of our organism, while promoting general health.

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Influence of Short-Chain Fatty Acids on Iron Absorption by Proximal Colon

Abstract: The proximal colon could be a significant site available for iron absorption; this absorption can be enhanced by local production of short-chain fatty acids such as propionate.

Cited by 71 publications

References 24 publications

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy

Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

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