Influence of signalment on developing cranial cruciate rupture in dogs in the UK

Adams, Phillip R.; Bolus, Roger; Middleton, Stephanie A; Moores, A. P.; Grierson, James

doi:10.1111/j.1748-5827.2011.01073.x

Cited by 59 publications

(74 citation statements)

References 11 publications

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“…rottweilers and Golden retrievers have been cited as breeds in which CCL disease is common (haraSeN, 2003). Compared to the studies by haraSeN et al (2003), aDaMS et al (2011 and taYLOr-BrOWN et al (2015), we noticed a lower incidence of CCL rupture in rottweilers (5.1%) and in West highland terriers and Yorkies (0.85%). On the other hand, Labradors and mixed breeds had a greater incidence of CCL rupture (21%).…”

Section: Resultscontrasting

confidence: 84%

“…Dogs aged 5 years and older had 2.5 times the odds of CCL rupture compared with dogs aged less than 5 years, P<0.01. there is a strong breed-related predisposition to CCL rupture in dogs (BaIrD, 2014). West Highland White Terriers, Yorkshire Terriers and Rottweilers had a significantly higher prevalence of CCLR, and Rottweilers had five times greater incidence compared with other pure breeds, with females twice as likely to suffer CCLr compared to males (aDaMS et al, 2011). In our retrospective study, dogs younger than 2 years accounted for only 2.6% of total dogs, and those older than 8 accounted for almost 31%.…”

Section: Resultsmentioning

confidence: 59%

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Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

et al. 2017

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rupture of the cranial cruciate ligament (CCL) remains the most common canine orthopaedic problem seen in clinical practice. the present paper describes a population of 117 dogs with CCL rupture diagnosed by clinical examination followed by mini-arthrotomy. the dogs were treated from January 2010 to February 2015 at the Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Croatia, by the same surgeon. The age, breed, gender and reproductive profile were analysed in relation to CCL rupture occurrence during the study and were discussed in relationship to previous published reports. Of the 117 dogs, 29.0% were mixed breed dogs and 13.7% Labrador retrievers as the most common. Males and females were equally affected. Bilateral rupture occurred in 5.85% cases, mostly in mixed breed females. Medial meniscal tear was observed in 22.2% of cases with mini-arthrotomy and probing. the average age of the small breed dogs was 8.3 years, and of the large breed dogs 4.2 years. Dogs aged 5 years and older had 2.5 times the likelihood of suffering from CCL rupture compared with dogs aged under 5 years (P<0.01).

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Section: Resultscontrasting

confidence: 84%

Section: Resultsmentioning

confidence: 59%

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

et al. 2017

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“…The evidence for a protective role of sex hormones in ligament integrity can be seen in the presence of gonadal hormone receptors on ligaments [41], the increase of ligament elastin content and fiber diameter in response to estrogen administration [42], and the greater likelihood of cruciate injury in female athletes when estrogen is low [43]. However, obese dogs are four times more likely to rupture their cranial cruciate ligament [44] and neutering is a factor highly associated with the development of obesity, with neutered females being more prone than neutered males [45]. An obesity association, distinct from the gonadal hormone role, driving the observed increase in RACL cannot be discounted.…”

Section: Discussionmentioning

confidence: 99%

Correlation of neuter status and expression of heritable disorders

Belanger

Bellumori

Bannasch

et al. 2017

Canine Genet Epidemiol

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BackgroundGonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds.ResultsNeutered dogs were at less risk for early and congenital conditions (aortic stenosis, early onset cataracts, mitral valve disease, patent ductus arteriosus, portosystemic shunt, and ventricular septal defect) than intact dogs. Neutering was also associated with reduced risk of dilated cardiomyopathy and gastric dilatation volvulus in males. Neutering was significantly associated with an increased risk for males and females for cancers (hemangiosarcoma, hyperadrenocorticism, lymphoma, mast cell tumor, and osteosarcoma), ruptured anterior cruciate ligament and epilepsy. Intervertebral disk disease was associated with increased risk in females only. For elbow dysplasia, hip dysplasia, lens luxation, and patellar luxation neutering had no significant effect on the risk for those conditions. Neutering was associated with a reduced risk of vehicular injury, a condition chosen as a control.ConclusionsIn this retrospective study, several conditions showed an increased risk associated with neutering whereas other conditions were less likely to be expressed in neutered dogs. The complexity of the interactions between neutering and inherited conditions underscores the need for reflective consultation between the client and the clinician when considering neutering. The convenience and advantages of neutering dogs that will not be included in a breeding program must be weighed against possible risk associated with neutering.Electronic supplementary materialThe online version of this article (doi:10.1186/s40575-017-0044-6) contains supplementary material, which is available to authorized users.

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“…Previous studies have reported prevalence estimates for CCL disease in dogs from 1.2% to 2.6% and identified risk factors including breed, sex, neutering, age, and bodyweight . A study of 1.25 million dogs in the USA from a predominantly referral population over a 40‐year period identified the 5 breeds most commonly affected as the Newfoundland, Rottweiler, Labrador Retriever, Bulldog, and Boxer .…”

mentioning

confidence: 99%

“…A study of 1.25 million dogs in the USA from a predominantly referral population over a 40‐year period identified the 5 breeds most commonly affected as the Newfoundland, Rottweiler, Labrador Retriever, Bulldog, and Boxer . Subsequent studies have confirmed increased prevalence in the Labrador Retriever, Newfoundland, Boxer, and Rottweiler as well as reporting predispositions in other breeds including the West Highland White Terrier, Yorkshire Terrier, Golden Retriever, Staffordshire Bull Terrier, Neapolitan Mastiff, Akita, Saint Bernard, Mastiff, Chesapeake Bay Retriever, and American Staffordshire Terrier …”

mentioning

confidence: 99%

Epidemiology of Cranial Cruciate Ligament Disease Diagnosis in Dogs Attending Primary‐Care Veterinary Practices in England

et al. 2015

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Objective To estimate the prevalence and risk factors for a diagnosis of cranial cruciate ligament (CCL) disease in dogs and to describe the management of such cases attending primary‐care veterinary practices. Study design Historical cohort with a nested case–control study. Sample population Nine hundred and fifty‐three dogs diagnosed with CCL disease from 171,522 dogs attending 97 primary‐care practices in England. Methods Medical records of dogs attending practices participating in the VetCompass project that met selection criteria were assessed. Univariate and multivariate logistic regression methods were used to evaluate association of possible risk factors with diagnosis of CCL disease. Results The prevalence of CCL disease diagnosis was estimated at 0.56% (95% confidence interval 0.52–0.59). Compared with crossbred dogs, Rottweilers, West Highland White Terriers, Golden Retrievers, Yorkshire Terriers, and Staffordshire Bull Terriers showed increased odds of CCL disease diagnosis while Cocker Spaniels showed reduced odds. Increasing bodyweight within breeds was associated with increased odds of diagnosis. Dogs aged over 3 years had increased odds of diagnosis compared with dogs aged less than 3 years. Neutered females had 2.1 times the odds of diagnosis compared with entire females. Insured dogs had 4 times the odds of diagnosis compared with uninsured dogs. Two‐thirds of cases were managed surgically, with insured and heavier dogs more frequently undergoing surgery. Overall, 21% of cases were referred, with referral more frequent in heavier and insured dogs. Referred dogs more frequently had surgery and an osteotomy procedure. Conclusion Breed predispositions and demographic factors associated with diagnosis and case management of CCL disease in dogs identified in this study can be used to help direct future research and management strategies.

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Influence of signalment on developing cranial cruciate rupture in dogs in the UK

Abstract: Cranial cruciate ligament rupture is more likely in Rottweilers and in female dogs, older dogs and obese dogs. Following multi-variable analysis, it was established that neutering was not associated with increased risk of cranial cruciate ligament rupture.

Cited by 59 publications

References 11 publications

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

Breed, gender, age and reproductive status in relation to the predisposition for cranial cruciate ligament rupture in 117 dogs treated by a single surgeon (2010 - 2015) - a short communication

Correlation of neuter status and expression of heritable disorders

Epidemiology of Cranial Cruciate Ligament Disease Diagnosis in Dogs Attending Primary‐Care Veterinary Practices in England

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