Influence of social determinants of health on patients with advanced lung cancer: a prospective cohort study

Abstract

IntroductionSocioeconomic factors with an influence on human health are known as social determinants of health (SDH). There are some SDH studies in patients with lung cancer, but important exposures such as social isolation and loneliness have not been adequately investigated. This study will assess the influence of SDH, particularly social isolation and loneliness, on patients with advanced lung cancer in Japan.Methods and analysisThe inclusion criteria for this prospective cohort study will be as follows: a diagnosis of advanced lung cancer; unsuitability for curative surgery; and willingness to participate. The primary outcome will be the initial choice of treatment and the secondary outcomes will be overall survival, changes in disease staging or performance status, route to diagnosis and place of death. The exposures will be social isolation, loneliness, employment, insurance type, education and dementia. The study enrolment period will be 1 year and the follow-up duration will be 2 years. The log-rank test will be used to compare overall survival between patients when grouped according to the study exposures and multivariate analysis will be performed using Cox proportional hazards regression. The Χ2 test will be used to compare the initial treatment, changes in disease stage and place of death, and logistic regression will be used for multivariate analysis of these factors. A p value <0.05 will be considered statistically significant.Ethics and disseminationThis study has been approved by the Institutional Review Board at Hyogo Prefectural Amagasaki General Medical Center (No 29-164). A manuscript summarising the outcome of this study will be submitted to a peer-reviewed journal and the data will be presented at conferences.Trial registration numberUMIN000031810.

Racial Disparity and Social Determinants in Receiving Timely Surgery Among Stage I–IIIA Non-small Cell Lung Cancer Patients in a U.S. Southern State

“…Social support has been found to be a protective factor for the prevention and maintenance of many diseases (25). Previous studies reported that being married is a predictor of receiving standard care and better outcomes (26)(27)(28), while experiencing social isolation or loneliness has a negative influence on lung cancer patients (29). In our study, being married showed a similar protective effect for receiving timely surgery in both white and black patients, while the insignificance of the OR among black patients may be due to the smaller sample size of black patients in our study.…”

Influence of loneliness and social isolation on the diagnosis and treatment of Japanese patients with advanced lung cancer: a prospective cohort study

“…The study was performed at a Japanese tertiary referral hospital (Hyogo Prefectural Amagasaki General Medical Center) between April 2018 and March 2020. The study protocol has previously been published (11) and was approved by the Hyogo Prefectural Amagasaki General Medical Center (# 29-164). The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).…”

Recent research on the social network concept and cancer

“…] (timely surgery), [3] (algorithm for physician networks), [11] (adherence), [25] (adherence), [28] (treatment patterns), [59] (screening), [63] (screening; review), [ ] (virality of info), [34], [36] (knowledge), [37], [56] (social media messages), [57] (social media accuracy), [71] (academic productivity), [72] (academic collaboration) All studies using dyadic data (measured ties between any two entities) are marked with an underline. Social support 43% [4,5], [6] (youth; review), [8,9], [10 && ] (network index), [11], [15] (review), [16,18,19,22,24,25], [31 && ] (review), [32,33,40,41], [42] (partners), [44,45,[49][50][51][52][53]61,64,66,68], [69] (review),…”

“…are used when a characteristic is suggested by not clearly stated in a manuscript. ], [15] (review), [16,18,19,24], [26] (social media), [30], [31 && ] (review), [35] (social integration), [36,45], [46] (needs returning to work), [48], [50] (changing relationships), [51] (needs for informal support), [52] (roles), [53] (perceived), [58] (information seeking; review), [60] (isolation), [62] (perceived support, alienation), [62], [63] (review), [68] (social roles, social support), [69] (social support; review), [74] Quality of life 14% [5,8], [14] (social/family wellbeing), [22,25], [33] (life satisfaction), [36,41,42], [48] (social/family wellbeing), [49,51,68,73] Mental health 19% [8] (distress), [10 && ], [11] (depression, alcohol), [32] (depression), [33] (depression, anxiety), [34] (distress, burden),…”

“…are used when a characteristic is suggested by not clearly stated in a manuscript. [15] (youth), [16] (survivorship), [17], [21] (psychology), [25] (psychology), [28], [30] (youth), [33,34,35], [36] (education), [40,41], [42] (nursing), [43] (survivorship), [44], [45] (psychology), [46] (nursing), [47] (psychology), [48] (psychology), [49] (psychology), [51] (social work), [52] (education), [53] (psychology), [54] (prevention), [55] (education), [57] (education), [58] (psychology), [59,60], [64] (nursing), [66] (support), [67] (psychology), [69], [70] (education), [71,73], [74] (psychology) Medicine 5% [12] (behavior), [24,26,61], [63] (preventive), [68] (behavior), [72] Public health 9% …”