Influence of Sodium Intake on Exchangeable Sodium in Normal Human Subjects*

Jagger, Paul I.; Hine, Gerald J.; Cardarelli, John A.; Burrows, Belton A.

doi:10.1172/jci104830

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…The effective half-period of elimination was 513 days, corresponding to a biological half-life of about 1,000 days. The value for the effective half-life was in accord with that of 445 days reported by Richmond (1958) and 475 days reported by Jagger, Hine, Cardarelli and Burrows (1963). Tho final example concerned two women whose body radioactivity had been measured during the period 5-12 weeks following the administration of 131 1 in tests for thyroid function.…”

Section: Use Of Whole-body Counters In Radiological Protectionsupporting

confidence: 81%

Use of Whole-Body Counters in Radiological Protection

Vennart¹

1964

Nature

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Section: Use Of Whole-body Counters In Radiological Protectionsupporting

confidence: 81%

Use of Whole-Body Counters in Radiological Protection

Vennart¹

1964

Nature

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“…Kidneys, liver, muscle, and skin equilibrate with blood within 20-60 min, but brain and testes may require several hours to equilibrate with blood (Manery andBale 1941, Forbes andPerley 1951). Following IV administration of 22 Na to normal human subjects, activity in the knees and skull increased for 24-48 h after the activity in serum had leveled off, suggesting that 1-2 days were required for bone Na to equilibrate with Na in serum (Jagger et al 1963).…”

Section: Powlesmentioning

confidence: 99%

A biokinetic model for systemic sodium

Samuels

Leggett

2021

J. Radiol. Prot.

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This paper describes an updated biokinetic model for systemic sodium (Na), developed for use in a series of reports by the International Commission on Radiological Protection (ICRP) on occupational intake of radionuclides. In contrast to the ICRP’s previous model for intake of radio-sodium by workers, the updated model depicts realistic directions of movement of Na in the body including recycling of activity between blood and tissues. The updated model structure facilitates extension of the baseline transfer coefficients for adults to different age groups and to special exposure scenarios such as transfer of radio-sodium from the mother to the foetus or the nursing infant. Dose coefficients for 22Na and 24Na based on the updated model generally do not differ greatly from those based on the ICRP’s previous Na model when both models are connected to the ICRP’s latest dosimetry system. The main exception is that the updated model yields roughly twofold higher dose coefficients for endosteal bone surface than does the previous model due to the dosimetrically cautious assumption in the updated model that exchangeable Na in bone resides on bone surface.

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“…However, many investigators have found that the plasma concentrations correlate poorly with total body electrolytes (Burnell et al, 1956;Cort and Matthews, 1954;Cox et al, 1964;Darrow et al, 1949;Dole et al, 1951;Duncan et al, 1956;Edelman et al, 1958;Garrow, 1965;Howe and Le Quesne, 1964;Jagger et al, 1963;Keitel and Jones, 1959;MacPhee, 1953;Moore et al, 1963;Nichols and Nichols, 1953;Randall and Papper, 1958;Soloff et al, 1960;Talso et al, 1956).…”

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confidence: 99%