Influence of Somatic Comorbidity on the Course of Coronary Heart Disease

Ахмедова, Э. Б.; Марданов, Б. У.; Мамедов, М. Н.

doi:10.15829/1560-4071-2017-9-55-59

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…As shown in Table 3, in patients with a combination of AH and COPD, the negative association of GFR was recorded with age, heart rate, concentration of cholesterol, HDL cholesterol, LDL cholesterol, and cystatin C of serum. The noted correlation characteristics are to some extent explained by a more pronounced inflammatory syndrome [19], endothelial dysfunction, oxidative stress and stiffness of the vascular wall, which, in turn, contributes to the progression of the atherosclerotic process and potentiates adverse cardio-and nephrocerebral effects.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Муркамилов

Fomin²,

Айтбаев³

et al. 2019

ASOAJ

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Purpose of the study:To study the content of cystatin C and to identify the factors reducing the glomerular filtration rate in patients with comorbid pathology.Materials and methods: 383 patients with comorbid pathology aged from 25 to 88 years (mean age 58.8±12.0 years) were examined, of whom 51.4% were men and 48.6% women. In the structure of comorbid pathology, arterial hypertension (AH) was observed in 76.5%, coronary heart disease (CHD) in 48.8%, diabetes mellitus (DM) type2 in 29.7%, obesity in 47, 5% and chronic obstructive pulmonary disease (COPD) in 28.9% of patients. The examined patients were divided into 4 groups: 1 st persons with hypertension+type2 diabetes (n = 99); 2 nd -AH + CHD (n = 138); 3 rd -AH + COPD (n = 102) and the 4 th group patients with severe comorbid pathology, i.e. AH + DM + CHD + COPD (n = 44). All patients were studied for lipid spectrum parameters [total cholesterol (cholesterol), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), triglycerides (TG)] and cystatin C of blood plasma. The glomerular filtration rate (GFR) was calculated according to the formula F.J. Hoek. The severity of renal dysfunction was assessed according to the recommendation of KDIGO (Kidney Disease: Improving Global Outcomes) 2012. The analysis of the prevalence of reduced GFR in patients with comorbid pathology was also carried out. Results:The presence of reduced GFR gradations of C2 and C3 "A" was detected in 46.7% and 24.8% of the examined individuals, respectively. Severe reduction in GFR was observed in 11.7% of patients. Sharply reduced GFR (C4 gradation) was significantly more frequently registered in women than in men (10.7% versus 5.0%; p <0.05). In the examined cohort, persons of middle and old age made up 36.8% and 42.2%, respectively. In patients with comorbid pathology, cases of hypercholesterolemia (41.7%), hypertriglyceridemia (45.4%) and elevated levels of LDL cholesterol (46.9%) were frequently detected, and in the 4 th group, the mean age and body mass index (BMI) were significantly higher, and cholesterol levels of HDL and GFR were significantly lower compared with other groups. In the 1st group (AH+DM type2), systolic blood pressure (SBP), total cholesterol and cystatin C plasma levels were significantly higher than in the AH+CHD, AH+COPD groups and patients with severe comorbid pathologies. Higher concentrations of LDL cholesterol were observed in patients with hypertension and COPD. In the 1 st group of patients, the GFR value closely correlated with age (r=-0.21; p=0.03), the level of SBP (r=-0.34; p=0.03), and concentration cystatin C of blood plasma (r=-0.87; p=0.01). In the 2 nd subgroup, the GFR index was associated with the level of the SBP (r=-0.32; p=0.03) and the concentration of cystatin C in the blood plasma (r=-0.86; p=0.03). In patients with AH, COPD negative association of GFR was recorded with age (r=-0.44; p=0.03), heart rate (r=-0.36; p=0.03), total cholesterol concentration (r=-0.20; p=0.04), HDL cholesterol ...

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Section: Discussionmentioning

confidence: 99%