Influence of Soy Lecithin Administration on Hypercholesterolemia

Mourad, A; Pincinato, Eder de Carvalho; Mazzola, Priscila Gava; Sabha, Maricene; Moriel, Patrícia

doi:10.1155/2010/824813

Cited by 28 publications

(24 citation statements)

References 30 publications

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“…Soy lecithin decreased the total cholesterol (-7.51%) and the fraction LDL (-26.24%), but increased the fraction HDL (+33.93%). Some researchers showed that a diet containing lecithin modifies the cholesterol homeostasis in the liver, reducing the excess LDL, and promoting the synthesis of a great amount of HDL in the liver (Mourad et al, 2010). There is also an inhibition of the acyl-CoA cholesterol acyltransferase (ACAT) by the SL consumption, and lower ACAT activity was associated with lower, free, and esterified cholesterol content, which may be rapidly directed to the elimination in the bile, or may be converted into biliar acids (LeBlanc et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

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Physiological parameters and productive performance of rabbit does and their offsprings with dietary supplementation of soy lecithin

Attia

El-Hamid

Oliveira

et al. 2018

Pesq. agropec. bras.

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The objective of this work was to evaluate the effect of a dietary supplementation with soy lecithin (SL) on the productive performance and blood constituents of rabbit females and their offsprings. A total of 40 rabbits does were distributed into four treatments: control group, no dietary SL inclusion; and three groups with 0.5, 1.0, and 1.5% SL inclusion in the diets. The inclusion of 1.5% SL increased the count of blood cells and hemoglobin concentrations; 0.5-1.0% SL reduced the total cholesterol levels in the blood, as well as the low-density lipoprotein-cholesterol and the activities of the enzymes alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase, but increased the levels of total lipids, triglycerides, high-density lipoprotein-cholesterol, and the activities of the antioxidant enzymes. Supplementation with 1.0-1.5% SL resulted in higher milk production and heavier litters. Soy lecithin supplementation at 1% improves the physiological parameters and increases the milk production of rabbit does, also improving the performances of their offsprings.

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Section: Resultsmentioning

confidence: 99%

“…Diets supplemented with SL may result in lower levels of total cholesterol (Attia & Kamel, 2012) and of low-density lipoprotein-cholesterol (LDL-cholesterol) (Mourad et al, 2010). According to LeBlanc et al…”

Section: Introductionmentioning

confidence: 99%

Physiological parameters and productive performance of rabbit does and their offsprings with dietary supplementation of soy lecithin

Attia

El-Hamid

Oliveira

et al. 2018

Pesq. agropec. bras.

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“…22 FDA and German Cancer Research Centre, Heidelberg stated that Soy phosphatidylcholine has no carcinogenicity and no risk in formation of tumour. 23,24 Additionally, PC is said to have varied advanced beneficial properties like hepatoprotective activity, 25 nutritional supplement to support brain health, 26 role in membrane fluidity, 27 shows superior host defences (like enhancing NK cell activity and phagocytosis), 28 excellent emulsifying activity, 29 major component of the gastric mucosa lining of the stomach protecting from ulcer, 30 precursor for acetylcholine, 31 reducing serum cholesterol, 32 improving the perception of taste and smell, 33 recuperate fatigue 34 and even in nourishing skin. 35 …”

Section: Phospholipid Source and Its Additional Benefits As Adjuvantmentioning

confidence: 99%

Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents

Gnananath¹,

Nataraj²,

Rao³

2017

Adv Pharm Bull

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Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing these stumbling blocks either by enhancing the solubilizing capacity or its potentiating ability to pass through the biological membranes and it also protects the active herbal components from degradation. Hence, this phospholipid-complex-technique can enable researchers to deliver the phytoconstituents into systemic circulation by using certain conventional dosage forms like tablets and capsules. This review highlights the unique property of phospholipids in drug delivery, their role as adjuvant in health benefits, and their application in the herbal medicine systems to improve the bioavailability of active herbal components. Also we summarize the prerequisites for phytosomes preparation like the selection of type of phytoconstituents, solvents used, various methods employed in phytosomal preparation and its characterization. Further we discuss the key findings of recent research work conducted on phospholipid-based delivery systems which can enable new directions and advancements to the development of herbal dosage forms.

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“…It is available from sources such as soybeans, eggs, milk, cottonseed, and sunflower. Researches indicated that lecithin increase good cholesterol and decrease bad ones [10], [11]. Miranda et al, [12] found that daily lecithin supplementation increased macrophage activity which can engulf cancerous cells in the body by 29% on rats that suggest increase the immune function.…”

Section: Introductionmentioning

confidence: 99%

Ifosfamide toxicity to the retina and the possible roles of lecithin and quercetin in albino rats

Ahmed¹,

Aly

Mahmoud

et al. 2018

IJET

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Background: During cancer chemotherapy, drug-induced oxidative stress can limit therapeutic efficiency and cause a number of side effects. Objectives: Our study aimed to characterize the side effects of an alkylating agent chemotherapy ifosfamide to the retina and if the supplementation of lecithin and or quercetin can diminish its oxidative stress by means of comet assay and FTIR.Methods: Seventy female albino rats divided as control, rats given orally quercetin or lecithin, rats injected with ifosfamide, rats given quercetin or lecithin and in combination of them with ifosfamide injection.Results: Lecithin and quercetin groups indicate a normal comet parameters and distribution of protein secondary structure components content of β-turn, α-helix and β-sheet. After Ifosfamide injection, all comet parameters and β-Turns content were significant increase (p˂0.05) with the same context significant decrease (p˂0.05) of α-helix was observed. Lecithin or quercetin reduces the effect of ifosfamide injection in tail length and percentage tailed DNA. Combined treatment gives more protection against DNA damage. Lecithin role is cleared in returning the normal distribution of β-turn, α-helix, β-sheet and lack of protective effect of quercetin regarding the protein secondary structure of retina was observed.Conclusion: We suggest using lecithin and quercetin in combined treatment to reduce the oxidative stress due to ifosfamide.

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Influence of Soy Lecithin Administration on Hypercholesterolemia

Cited by 28 publications

References 30 publications

Physiological parameters and productive performance of rabbit does and their offsprings with dietary supplementation of soy lecithin

Physiological parameters and productive performance of rabbit does and their offsprings with dietary supplementation of soy lecithin

Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents

Ifosfamide toxicity to the retina and the possible roles of lecithin and quercetin in albino rats

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