Influence of Spinal and General Anaesthesia on Haemostasis During Total Hip Arthroplasty

Davis, F. M.; McDermott, Enda; Hickton, C.; Wells, Elisabeth; Heaton, D. C.; Laurenson, V. G.; Gillespie, W. J.; Foate, J.

doi:10.1097/00132586-198802000-00030

Cited by 8 publications

(13 citation statements)

References 28 publications

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“…These include the type of operation performed [5] and the type of anesthesia [8]. Postoperative changes in cytokine level are affected by even more factors.…”

Section: Discussionmentioning

confidence: 99%

Changes in the blood coagulation, fibrinolysis, and cytokine profile during laparoscopic and open cholecystectomy

et al. 2004

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Only mild hypercoagulability was observed in patients who had undergone laparoscopic cholecystectomy. The cytokine surge was correlated with hypercoagulability. There was in fact a positive correlation between IL-6 level and hypercoagulability. The correlation between cytokine levels and coagulation activation may be related to the type of surgery performed. Further studies are required to investigate these issues.

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“…These include the type of operation performed [5] and the type of anesthesia [8]. Postoperative changes in cytokine level are affected by even more factors.…”

Section: Discussionmentioning

confidence: 99%

Changes in the blood coagulation, fibrinolysis, and cytokine profile during laparoscopic and open cholecystectomy

et al. 2004

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“…Major determinants for perioperative activation of the coagulation cascade are the type and duration of surgery, anesthesia, and autologuous or allogenic transfusions [16][17][18]. Furthermore, perioperative stress response may have some additive adverse effects on coagulation supporting thrombosis and embolism, eg, deep vein thrombosis (DVT), pulmonary embolism (PE), MI, and cerebral infarction [3,9].…”

Section: Discussionmentioning

confidence: 99%

The effect of clonidine on perioperative blood coagulation

Ganter¹,

Hofer²,

Spahn³

et al. 2005

Journal of Clinical Anesthesia

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“…Anaesthesia can contribute to changes in coagulation and fibrinolysis during and after surgery (1)(2)(3)(4)(5)(6)(7)(8). This may be important in the pathogenesis of thromboembolic (TE) complications.…”

mentioning

confidence: 99%

Coagulation and fibrinolytic parameters in patients undergoing total hip replacement: influence of the anaesthesia technique

Donadoni

Baele

Devulder

et al. 1989

Acta Anaesthesiol Scand

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Eighty patients undergoing total hip replacement (THR) were randomly allocated to three groups. Group I (n = 29) received general anaesthesia, Group II (n = 29) epidural anaesthesia and Group III (n = 22) the same epidural as Group II and the same general anaesthesia as Group I but with a lower isoflurane concentration. Prothrombin time (PT), activated thromboplastin time (APTT), fibrinogen (FG), plasminogen (PG), antithrombin III (AT III), protein C (Proc C), alpha-2-antiplasmin (alpha 2AP), Factor VIII coagulating activity (F VIII:C), von Willebrand factor antigen (vWF:Ag), von Willebrand ristocetin cofactor (vWF:Rcof), tissue plasminogen activator (tPA) as antigen and activity were measured before induction (A), at the end of surgery (B), on the first postoperative morning (C) and 7 days postoperatively (D). The most relevant finding was that AT III was equally depressed immediately after surgery in all groups, but returned to normal significantly faster in the epidural group (mean values at C: 96.2% in Group I, 104.1% in Group II, 92.7% in Group III). The faster return to normal of AT III after epidural anaesthesia could be one of the mechanisms responsible for the beneficial effect of this technique on the prevention of thromboembolic complications.

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Influence of Spinal and General Anaesthesia on Haemostasis During Total Hip Arthroplasty

Cited by 8 publications

References 28 publications

Changes in the blood coagulation, fibrinolysis, and cytokine profile during laparoscopic and open cholecystectomy

Changes in the blood coagulation, fibrinolysis, and cytokine profile during laparoscopic and open cholecystectomy

The effect of clonidine on perioperative blood coagulation

Coagulation and fibrinolytic parameters in patients undergoing total hip replacement: influence of the anaesthesia technique

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