Influence of splenectomy on the biodistribution of technetium-99m dimercaptosuccinic acid (99mTc-DMSA) in rats

Abstract

(88.8 ± 18.6 mg/dL) and creatinine (0.56 ± 0.08 mg/dL), compared to the controls (51.5±1.6, 0.37±0.02mg/dL, respectively), as well as increase in platelets and leucocytes, and hematocrit reduction. The analysis of the results indicates that in rats, splenectomy seems to alter the renal function and the uptake of 99mTc-DMSA.

Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

“…Study described by Açucena et al 18 showed that splenectomy in rats altered renal function and uptake of 99m Tc-DMSA. Stokland et al 9 showed that decreased uptake of 99m…”