Influence of Storage Conditions on the Stability of Gum Arabic and Tragacanth

Ramos, Paweł; Broncel, Mateusz

doi:10.3390/molecules27051510

Cited by 14 publications

(15 citation statements)

References 38 publications

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“…Parameter b* refers to the yellowness of the samples. Positive and negative b* indicates yellow and blue color, respectively [ 21 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

“…These methods have shown their usefulness in our previous studies for the identification of single- and dual-component preparations containing theophylline [ 18 ]. In addition, other authors have demonstrated their usefulness in the pharmaceutical industry for the identification of polymorphic substances [ 19 , 20 ], the influence of ambient relative humidity on vapor sorption [ 21 ], thermal stability [ 22 , 23 ], or compatibility of excipients with API [ 24 , 25 , 26 , 27 ] and API with API [ 28 ], as well as quality control in pharmacies [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Ramos,

Raczak,

Silvestri

et al. 2023

Pharmaceutics

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Naproxen is one of the most used non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat pain of various origins, inflammation and fever. Pharmaceutical preparations containing naproxen are available with prescription and over-the-counter (OTC). Naproxen in pharmaceutical preparations is used in the form of acid and sodium salt. From the point of view of pharmaceutical analysis, it is crucial to distinguish between these two forms of drugs. There are many costly and laborious methods to do this. Therefore, new, faster, cheaper and, at the same time, simple-to-perform identification methods are sought. In the conducted studies, thermal methods such as thermogravimetry (TGA) supported by calculated differential thermal analysis (c-DTA) were proposed to identify the type of naproxen in commercially available pharmaceutical preparations. In addition, the thermal methods used were compared with pharmacopoeial methods for the identification of compounds, such as high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectrophotometry, and a simple colorimetric analyses. In addition, using nabumetone, a close structural analog of naproxen, the specificity of the TGA and c-DTA methods was assessed. Studies have shown that the thermal analyses used are effective and selective in distinguishing the form of naproxen in pharmaceutical preparations. This indicates the potential possibility of using TGA supported by c-DTA as an alternative method.

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“…Parameter b* refers to the yellowness of the samples. Positive and negative b* indicates yellow and blue color, respectively [ 21 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Ramos,

Raczak,

Silvestri

et al. 2023

Pharmaceutics

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“…Many patients store medications before use contrary to the manufacturers’ recommendations [ 7 ]. In consequence, environmental conditions such as elevated temperature or UV radiation [ 8 , 9 ] may lead to the loss of original properties. For this reason, it is extremely important to properly protect the finished product and store it under appropriate conditions.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Directional–Hemispherical Reflectance of Tablets with Cefuroxime during Storage under Elevated Temperature and Ultraviolet Radiation

Meisner,

Sarecka-Hujar

2024

Sensors

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Environmental conditions can lead to changes in the physical and chemical structures of drug products. In this study, the stability of cefuroxime tablets stored under adverse conditions was evaluated based on total directional–hemispherical reflectance (THR). The THR value was measured before and after the tablets’ exposure to stress factors (temperature of 45 °C and UV radiation). Each measurement was performed three times within seven spectral bands at the beginning of the experiment (day 0), and then on days 1, 2, 3, 5, and 7. In addition, hyperspectral profiles (400–1030 nm) were analyzed on days 0 and 7. A significant decrease in THR values in all wavelength ranges was observed when day 7 vs. day 0 were compared, especially for spectral bands of 335–380 nm and 1700–2500 nm (Δ = 0.220, p < 0.001 and Δ = 0.171, p < 0.001, respectively). The hyperspectral analysis confirmed a decrease in the reflectance after the end of stress conditions in the visible light range (400–700 nm) compared to tablets before the experiment. This may indicate that more radiation entered the tablets. In conclusion, the THR of cefuroxime tablets decreases during the exposure to heat and UV radiation, which may result from some physicochemical changes that have occurred during storage.

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“…Pre-formulation tests encompass compatibility tests of the ingredients used in the formulation, as well as aging tests conducted under stressful conditions. These tests involve subjecting the formulation to short-term exposure to extreme conditions, such as a temperature range of 40 °C to 70 °C and a relative humidity (RH) of 75%, typically for a duration of 14 days [ 6 , 7 ]. Additionally, pre-formulation tests include the assessment of the formulation’s response to UV radiation [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

et al. 2023

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Propolis is known as a source of compounds with strong antibacterial activity. Due to the antibacterial effect against streptococci of the oral cavity, it seems to be a useful agent in decreasing the accumulation of dental plaque. It is rich in polyphenols which are responsible for a beneficial impact on the oral microbiota and antibacterial effect. The aim of the study was to evaluate the antibacterial effect of Polish propolis against cariogenic bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined on cariogenic streptococci related to the occurrence of dental caries. Lozenges based on xylitol, glycerin, gelatin, water, and ethanol extract of propolis (EEP) were prepared. The effect of prepared lozenges on cariogenic bacteria was assessed. Propolis was compared to chlorhexidine which is used in dentistry as the gold standard. In addition, the prepared propolis formulation was stored under stress conditions to assess the influence of physical conditions (i.e., temperature, relative humidity, and UV radiation). In the experiment, thermal analyses were also performed to evaluate the compatibility of propolis with the substrate used to create the base of lozenges. The observed antibacterial effect of propolis and prepared lozenges with EEP may suggest directing subsequent research on prophylactic and therapeutic properties decreasing the accumulation of dental plaque. Therefore, it is worth highlighting that propolis may play an important role in the management of dental health and bring advantages in preventing periodontal diseases and caries as well as dental plaque. The colorimetric analyses carried out in the CIE L*a*b* system, microscopic examinations, and TGA/DTG/c-DTA measurements indicate the unfavorable effect of the tested storage conditions on the lozenges with propolis. This fact is particularly evident for lozenges stored under stress conditions, i.e., 40 °C/75% RH/14 days, and lozenges exposed to UVA radiation for 60 min. In addition, the obtained thermograms of the tested samples indicate the thermal compatibility of the ingredients used to create the formulation of lozenges.

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Influence of Storage Conditions on the Stability of Gum Arabic and Tragacanth

Cited by 14 publications

References 38 publications

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Assessment of Directional–Hemispherical Reflectance of Tablets with Cefuroxime during Storage under Elevated Temperature and Ultraviolet Radiation

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

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